Our Zener has lots of appy issues, and he is currently on 1/4 ondansetron tablet twice a day, also 1/8 zantac twice a day. We used pepcid for quite a while and read in LL that zantac can do the same as well as help with motility. The zantac with a touch of miralax once a day seems to keep things moving for him. We use 1/4 a tablet or less of cyprohexadine when we cannot get him to eat, sometimes just a pin head piece will do it, but on occasion we have to use a bit more. When we first used cypro, our previous vet prescribed 1 pill twice a day. And, we were not given any anti-nausea meds with the appy stimulant. Fortunately, we read here that the usual dose was often too high. And we also learned from Karrie, to not give appy stimulants without treating nausea. After a bout of vomiting and not eating, where we had to assist feed for several days, we used cerenia injections with good results. We used 3-5 days of cerenia injections a couple of times and recently started using 1mg cerenia (1/4 tablet) every other day as maintenance. Newer research shows that cerenia helps with GI pain and inflammation as well as treating vomiting. We hate giving the big guy so many meds, but if he doesn't eat and doesn't keep it down, then we can't give the insulin. We hope things improve for JD and we understand how difficult it is when our kitties won't eat. We are sending heaps of healing vines your way.