I'm sorry that J.D. isn't feeling well.
I believe that you are giving pepcid, ondansetron, cyproheptadine, B12 shots, and adequan injections. I think you have also given Bupe in the past for pain. Adding in the cerenia as suggested above might help. Not only is it used for vomiting, it is also thought to help control visceral pain.
Is cerenia another pill? Would it be okay to mix it with everything else he gets?
Increased drinking and urination does bring kidney problems to mind, in addition to the thyroid and pancreatitis issues that have been mentioned. When you take him in, the vet should run a full blood panel, and include a T4. He should also do a urinalysis to check urine specific gravity (USG), which will also give you an idea of how the kidneys are functioning.
He had a Total Health Plus the end of November (with T4), a Total Health in February (without T4) and another Total Health Plus on March 20th. I have a feeling he doesn't need more blood work. What do you think?
I think I will ask for the USG test.
Abnormal kidney function can cause a cat to feel nauseated, due to the presence of excess toxins in the blood. I have also heard that abdominal pain can cause cats to drink more. Would it be possible to measure how much water J.D. is drinking to see if it various daily? It might be helpful if you can tell the vet how much he is drinking daily. Are his teeth OK? He has a tooth in the back of his mouth that the vet says he doesn't think should be pulled because of his age and his condition. I have asked at least 20 or 30 times, both him and another vet at the practice say they wouldn't risk it, and the tooth is not getting worse :roll: Anything painful in his mouth that would cause him to not eat? Is he constipated? I think so, off and on. This morning he had two small prezzies and I didn't feel them but they looked hard. He did poo a little more during the day today, but not a lot. No vomiting? No. Is he well hydrated? He drinks a ton of water. Pinch his scruff between your fingers and twist it 90 degrees. It should snap back in place quite quickly if he is hydrated. You could ask the vet about sub Q fluids. The vet said he was not dehydrated the last time we saw him, and I just did the twist test and it snapped back in place, and I have done it before in recent weeks and he seems fine.
As far as his painful leg, just run your hand over it gently to feel for any lesions or lumps on the foot or the leg, and note if he reacts with pain if it is touched. I found that Emily did well with some heat pads under her bedding (very well insulated to prevent burns) to help with her arthritis. If his leg is hurting, maybe he does not want to get up to eat. If his tummy is full from drinking, maybe he does not want to eat. The vet has said he has had a "creeky leg" for years, and it does always seem to be the right back leg that takes the shorter step (so I guess that's how you tell which one hurts). I think he is filling his tummy up with water, and does not want to eat. Tonight, he ate a little of his 2nd dinner and drank a bunch of water. I just got back from doing the twist test and I just heard him at the water again. I wish he would just eat his food. I'm going to give him some more cypro, tonight.
I don't know if your vet would feel that you are dealing with chronic pancreatitis, or if there may be IBD which is causing him to feel uncomfortable. The vet should be able to palp[ate his abdomen and see if anything feels wrong, or if J.D. seems painful. Do you want to consider more diagnostics such as abdominal ultrasound? Maybe start with an abdominal X Ray when you go in? Ask the vet if he thinks it would be worthwhile. I certainly know, after dealing with Bear Man, how stressful it is to have a cat who doesn't want to eat. Add in the PU/PD and the arthritis issues, and he is becoming a complicated kitty. I think you are doing the right thing taking him in to the vet.