Update on Marair

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Mel Flagg

Member Since 2023
So I read through the Prozinc sticky for the millionth time yest. And I was like.. What if I did every 8 hours? Because his BS always starts to rise at that 8 hour mark (sometimes at 7).

So I did.

He's currently at 135!!!

He's been in the 400s and 500s for the 2 weeks, so this is a breakthrough (although I'm holding my breath that he doesn't bounce because I did increase the dose). I'm curious to see what his BS does in an hour. If my theory is correct, he'll start to rise or he'll hold at this number. I'm going to try to check him every hour for the rest of the day to see what happens and update my spreadsheet for anyone following along. Keep your fingers crossed ya'll.
 
So I read through the Prozinc sticky for the millionth time yest. And I was like.. What if I did every 8 hours? Because his BS always starts to rise at that 8 hour mark (sometimes at 7).

So I did.

He's currently at 135!!!

He's been in the 400s and 500s for the 2 weeks, so this is a breakthrough (although I'm holding my breath that he doesn't bounce because I did increase the dose). I'm curious to see what his BS does in an hour. If my theory is correct, he'll start to rise or he'll hold at this number. I'm going to try to check him every hour for the rest of the day to see what happens and update my spreadsheet for anyone following along. Keep your fingers crossed ya'll.
Going to tag a prozinc user just to see what she says about shooting every 8 hours
@Suzanne & Darcy
 
Going to tag a prozinc user just to see what she says about shooting every 8 hours
@Suzanne & Darcy

I checked his BS an hour after that post and it was back up to 165. So it was definitely wearing off. The prozinc sticky posted in the forum says you can do it every 8 hours. I do have a call into my vet as well just to double check. I also texted an MD friend of mine about whether or not he could be metabolizing the insulin faster than the 12 hours it should last, and he did say yes, it's a common problem in people as well apparently. Who knew?

I'm checking him in about 20 minutes to see where we are, but I have a feeling it will still be above 150. I'm wondering if anyone else has had this issue with prozinc, so I'd be interested in what the person you tagged has to say!

Update: BS +1 was 196 (we stilllll risin... LOL)
 
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Mel -- help me out. Where exactly did you see that you can dose Prozinc every 8 hours?

Prozinc's duration is generally 12 hours. If you shoot every 8 hours, you are overlapping the doses while there is still insulin in your cat's system. There's the potential that if Marair has a late nadir, you could overlap the nadir and insulin onset. As a result, you could be truly fighting to keep numbers from tanking.

Could you also find a way to indicate where in the cycle you gave the shot at 8 hours. Was it at +8? What are you planning on doing for the next dose?
 
First - here's the passage from the prozinc dosing methods page. If you scroll all the way to the bottom you'll find this under microdosing:

"DOSING EVERY EIGHT HOURS

If your cat is consistently having an early nadir and the level is consistently rising 6-8 hours after the shot, the insulin may not be lasting long enough. You might consider shooting more often than every 12 hours. BUT PLEASE BE AWARE: This method is very hard on the caregiver because you need to be available to monitor more often and to shoot every 8 hours. If you can’t make that kind of commitment, don’t try shooting every 8 hours. But if you do decide that your cat’s situation warrants trying this, here’s how it’s done:
  • First, divide the total amount of insulin you are already giving over 24 hours by 3.
  • Then divide your 24 hour schedule into (3) eight hour sections.
  • The first time you attempt this it’s wise to do start during a curve, checking the BG levels every 2 hours.
  • If, by +8, the levels are rising, no longer falling, and to a level above your No-Shot range, you could give another shot.
  • Then wait 8 hours, test to be sure the level is rising, not falling, and is above your No-Shot range and give another shot.
Often this method is not long term, but allows the levels to stabilize in a few weeks. Make sure you only try this method with the guidance of this forum’s members and your vet."

Second, with 3 months of data on him (which gets sent to his vet weekly - I think I annoy her with this), I'm aware of when his nadir hits, and it's always right at the 7 - 7.5 hour mark. By 8 he's rising again. Just like today, when I went to give him his second shot at 12pm. He was at 135 at +7 hours, and at +8 his preshot was 165. One hour after his shot (1.12u) he was at 196. His +2 is now 244.

Third, his vet did call, and said yes, while it is rare, it can happen that the prozinc doesn't last the full 12 hours, and we might need to switch him to Lantus, but that it might be too expensive for us at this time. I was given the ok to do every 8 hours, as long as I continually monitor him and adjust his dose as needed (hence the 1.12u instead of 1.25u due to him being under 200 - per his vet, although I think we should have done 1.25u because of how quickly he rises at the 8 hr mark). Also the only time Marair has ever had hypoglycemia is when he was on 2u bid.

On the spreadsheet, since there are only 2 spots for injections, I'm using a second line for the third injection for a given date. If you look on today's date, you'll see the 165 in the +8 cell, and then in the PMPS cell you'll see that 165 indicating that I gave him the shot after that reading. But if it's easier, I can add a comment to the cell.

Hopefully all that made sense. It did in my head anyway LOL
 
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