04/12 - New member - Shen's one week update on Insugen 30/70 40IU

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Nimi S

Member Since 2023
Starting a new thread to share week 1 update and concerns. Please correct me if the title needs any changes.
Link to previous thread https://felinediabetes.com/FDMB/thr...steroid-induced-diabetes.276271/#post-3063299

Today's the 7th day since the start of Shen's insulin treatment and also day 2 of changing the dose from 1.5U once daily to 1U twice daily (Insugen 30/70 40IU)

I'd like to summarize changes to his diet and behavior over the past 7 days.
He's on no other medication except for lubricating eye drops (Refresh tears) if he rubs on his eyes too much (once a day if at all).

Days 1-3 (06-08 Apr)
Diet: RC kitten in gravy, Whiskas adult chicken in gravy, Farmina Vetlife Obesity dry - wet:dry was around 60:40 or 70:30;
Behavior: continuous drooling post 1st insulin shot, tapered down towards day 3/4. At the first sign of drooling I'd rubbed glucose syrup on his gums & fed some wet food fearing low sugar as I wasn't able to work a glucometer that day.
Was lethargic and sleeping throughout, no begging for food but ate everything given.

Days 4-7 (09-12 Apr)
Diet: Barring one meal with Whiskas wet food on day 4, rest all meals have been Farmina obesity dry food. Had misunderstood some advice to not add more wet food to his earlier combo of wet and dry food and was planning on giving only dry food for a week while he's starting 2 shots per day. Rectified by adding back wet food to his diet (as per earlier proportions) by the end of day 8.
Behavior: Drooling had reduced considerably. Perked up a bit on day 4, asking for food on his own. Ate moodily on days 5 and 6. Day 6 had more drooling post PM shot (1st day of 2 shot dosing). Very minimal drooling today post AM shot.

His readings on day 6 and 7 (mostly in 400s :( )have been the highest. Is this what bouncing is?I thought the BG was supposed to fall to hypoglycemic levels to bring about bouncing. Since it's a human glucometer, the actual values would be a bit higher, right?
Does this warrant an increase to his current dose or is it too soon to make a change?


I updated the vet (who'd prescribed Insugen) about Shen's one week progress and based on the last few days of BG readings, he suggested upping the dose to 2.5U twice daily, starting with today's PM dose. I'm not very comfortable doing that even if his current BG is on an upward trend. Please advise!
He also did give an option to switch to Glargine at 2.5U twice daily but I'm still waiting on the u-100 syringes for another week or so.

I'm unsure if its relevant to Shen's recent BG readings but I've been using a new vial of insulin from day 4, since I feared that I had contaminated the first vial by pushing insulin within the syringe back into the vial in an attempt to remove air bubbles. Both vials have the same manufacturing and expiry dates.

DKA?
Today, while browsing some new posts by other members, I came across one of @Hendrick Cuddleclaw 's responses where they shared that when their cat went into DKA, he was zoned out, would go to the water bowl and just sit there in front of it, wavering back and forth. So this is something that I've observed Shen doing over the last few days. He goes and sits in front of the water, with his mouth nearly touching the water and takes about 30-60s before he actually starts drinking. Actually he does the same with the food - he doesn't dig in instantly like before but eventually finishes most or all of the food in his plate. I hadn't found this concerning so far and was attributing it to his lethargy.
Should I be reading more into this? Would the keto diastix help in figuring out anything? The one I'd done on Day 4 of his treatment had negative ketones.
He's had no episodes of diarrhea or vomiting. He's a healthy p**per and earlier used to throw up about once a week due to overeating or eating too quickly.

@Bandit's Mom
I was thinking of getting a Hypo tool box ready. Would you have any suggestions for medium and high-carb canned food brands, in case you've been using any?
- I usually have a few packets of Meo or Sheba treats lying around. Would they be any good in case of low sugar?
- Is honey a good alternative for Karo syrup? I'd used GluconD with some water last time.
- The nearest 24/7 vet clinic (SuperPets) for me is about 15kms away (35 mins w/o traffic). And I've also had an unexpectedly sad experience with them recently. Vets nearby are usually open between 11am-1pm and 6pm-9pm - it's terrifying to imagine any emergency arising between these hours.

Wet food
I got a response from the Purina team who informed me that all their Felix variants have 1.5% carbs in them. (I'm taking it with a pinch of salt) They don't have any of their other Fancy Feast varieties in India yet. So as of now I'll stick to Felix, get a few packets of it and see how Shen take's to them, whenever I do start introducing wet food to his diet.
 
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The higher numbers are most likely because you have gone back to the dry food exclusively. When I suggested you don’t change the food over to an all low carb diet for the first week of trying twice a day dosing, I meant for you to continue feeding as you had been and not adding any more low carb food. Sorry if I didn’t make myself clear. I think you could go back to feeding as you were on days 1 to 3 as you were giving a mixture of food then.
I would definitely not increase the dose to 2.5 units twice a day. I would stay at the 1 unit but go back to go feeding how you were in days 1-3. Let’s see how he goes with that.
He is most likely hanging over the water bowl because of the higher numbers. If you are testing for ketones, and it is a good idea to do that most days while he is in high numbers, and they are negative, you don’t have to worry about DKA. Ketones always precede DKA.
For the hypo kit, honey is fine. I used to use that.
 
What Bron said -- not a bad idea to check with ketostix once a day while he is still in the higher numbers. Ketones develop when BGs are too high for too long, combined with not enough food and not enough water. Water helps flush them out. Good idea to get extra food into him if possible to help keep ketones at bay. Add some water to the food too.
 
I was thinking of getting a Hypo tool box ready. Would you have any suggestions for medium and high-carb canned food brands, in case you've been using any?
- I usually have a few packets of Meo or Sheba treats lying around. Would they be any good in case of low sugar?
- Is honey a good alternative for Karo syrup? I'd used GluconD with some water last time.
- The nearest 24/7 vet clinic (SuperPets) for me is about 15kms away (35 mins w/o traffic). And I've also had an unexpectedly sad experience with them recently. Vets nearby are usually open between 11am-1pm and 6pm-9pm - it's terrifying to imagine any emergency arising between these hours.
There are no dearth of MC and HC brands of food in India. Only LC. LOL. Bandit eats only HC dry, so if I ever need to get her numbers up. I use honey. I too used GluconD initially! Once you are able to switch Shen to a low carb wet food, you can either use honey or any wet food with gravy etc whenever you need a carb boost.

If it's any consolation, I've never had a symptomatic hypo with Bandit in the 3.5 years that she has been on insulin (touch wood!). Yes, she has dipped to the 40s and even the 30s but I've always managed to bring her up by feeding carbs and testing every 20-30 mins.

I got a response from the Purina team who informed me that all their Felix variants have 1.5% carbs in them. (I'm taking it with a pinch of salt) They don't have any of their other Fancy Feast varieties in India yet. So as of now I'll stick to Felix, get a few packets of it and see how Shen take's to them, whenever I do start introducing wet food to his diet.
Did they say it was 1.5% on a dry matter basis? So the FF flavours available in India (that I see on Shakehands) are not LC?
 
When I suggested you don’t change the food over to an all low carb diet for the first week of trying twice a day dosing, I meant for you to continue feeding as you had been and not adding any more low carb food.

Yes, you did say not to add lower carb food while starting the twice a day dosing. Since I'd already been giving him only dry for a couple of days by then, I misunderstood what you meant :')
I've started adding wet food since the last 2 meals but I think for the past week I've generally been feeding him lesser than he needs to, so I'll have to rectify that as well.

I haven't really understood how the insulin, food, water and the timing of it all works, so I'd been assuming some stuff and messing up his diet, I think.


What Bron said -- not a bad idea to check with ketostix once a day while he is still in the higher numbers. Ketones develop when BGs are too high for too long, combined with not enough food and not enough water. Water helps flush them out. Good idea to get extra food into him if possible to help keep ketones at bay. Add some water to the food too.

Haven't been able to catch him peeing since yesterday. Will try the ketostix today.


If it's any consolation, I've never had a symptomatic hypo with Bandit in the 3.5 years that she has been on insulin (touch wood!). Yes, she has dipped to the 40s and even the 30s but I've always managed to bring her up by feeding carbs and testing every 20-30 mins.

That is encouraging to read! I'm not as worried about a low sugar event right now as I was when I started, especially with his nos. the last couple of days. But good to know it is manageable so long as I'm alert.

Did they say it was 1.5% on a dry matter basis? So the FF flavours available in India (that I see on Shakehands) are not LC?

I'll give this another check. The person I spoke to did say that the Fancy Feast flavors weren't low carb and only the Felix ones were. Maybe they had a certain % in mind while saying that and were comparing it to the Felix variants.
 
Managed to do a ketostix test (about 30 mins after his meal). His ketones today look to be somewhere between negative and trace, while glucose is very high.
His glucose on Sunday was the 3rd shade i.e. 1/2 (++) (glucometer readin ~315) but became darker while I waited 10 more seconds for the ketone result.
It's between 1 (+++) and 2 or more(++++) today (glucometer 473)

Shen_ketostix_09&13Apr.JPG


I feel bad that I've been messing with his diet all week. Hoping to see some improvement with the addition of wet food to his diet again.

Could anyone direct me as to what the ideal caloric requirements for diabetic cats are? Can he continue to receive the same amount of calories as were specified for his weight pre-diabetes?
Or should it be tapered down to bring him down to his ideal weight, assuming he still needs to lose a few lbs?

His appetite has increased (does this mean the insulin is not working/ not enough ? :(), he's still drooling a bit and while still lethargic, he's perkier than he's been the last few days.
 

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That is good the ketones look negative. Can you put the results of the ketone tests into the remarks columns of the SS please?
While he is unregulated he is going to be hungry because he is not absorbing all the nutrients in the food. We want him to eat well, so I would not restrict him at the moment. You could continue to use the amount of calories he had before diagnosis and see if that is enough. He may need a bit more while he is unregulated.
Is he drinking plenty of water?
 
Updated the diastix results in the SS remarks column.

Point noted on the food!

I feel his water intake has slightly reduced but he's having a drink as I type this.
I've also started adding water to his food as Hendrick suggested.


On a different note, do you all have any advice/links on how to be more informed about feline diabetes as a whole?
There's so much content to consume and no matter how much I read I still feel kind of uneducated at the end of it :confused:
I've been reading the Health Links / FAQs about Feline Diabetes here and I go through posts/topics that I might currently find relatable to glean more information.
I know that it's only been a week since we started but for some reason I feel like I'm racing against time and should know everything before and not after.

I do wish I'd learnt of and joined the FDMB sooner, but I'm glad that I found it at all :D
 
Thanks for adding the ketones result to the SS. We like to check the SS before helping you. I would suggest you set up a signature so we can find out about Shen. You will find how to do it in
Help us help you
When I first joined I read everything I could and read and reread posts and the advice that was given.
I think once you do the change over to Lantus, you will find it will be easier and clearer. There is a Lantus page that has information about Lantus and similar insulins that you might like to read but it is nothing like the insulin you are using now.

The insulins on this page are more similar to the one you are using at the moment
https://www.felinediabetes.com/FDMB/forums/caninsulin-vetsulin-and-n-nph.19/

My Sheba was first diagnosed in 2011 and I am still learning new things.
 
I've just updated my signature to reflect the addition of wet food to the diet.
Hope it's visible to all.

Thanks for the links. Will do some reading before his transition to Lantus.
 
I know that it's only been a week since we started but for some reason I feel like I'm racing against time and should know everything before and not after.

I do wish I'd learnt of and joined the FDMB sooner, but I'm glad that I found it at all :D

I remember this feeling well. It is all so overwhelming and it seems like a mountain of information to climb, new terms to understand, acronyms to learn, dosing methods....it IS a lot. And like you I did not have any patience for my own ignorance.

It was frustrating to me because it took time, probably about a month or so, before I felt like I had any clue what I was doing. It is a marathon not a sprint, members here would always say, but I wanted to know everything about this disease and how to treat my boy NOW DAMMIT.


you'll get there soon enough. I can tell you have the drive and determination.
 
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