TR vs SLGS

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chuckstables

Member Since 2022
Hey folks,

Concerned about sam's numbers. He got pretty low last night (50), went up pretty quickly with a bit of food with corn syrup. Now he's been above 300 the last 3 times I tested him today. This is likely a rebound I'd assume. He also doesn't want to eat wet food right now; he'll only eat the dry food. This started today mainly.

So I'm wondering if TR would be better for sam than SLGS? I'd probably try it out for a little while longer, but if I can't get him stabilized without any bounces/hypo's, then would TR be a better option? I just want him to be okay, and I'm worried now.
 
Bounces are going to happen whether you're doing TR or SLGS. They're just a frustrating part of treatment but usually, as the cat stays in normal numbers longer, the bounces don't go so high and don't last so long.

If you're doing SLGS, you should have reduced Sam's dose. If they drop below 90 (5), you immediately reduce by .25.

You are lucky that yesterday morning Sam did OK....we don't recommend shooting that low until you have more testing data and a better understanding of how Lantus works (and how it works in YOUR cat because every cat is different --ECID)

I would reduce Sam to 2.25 and then hold that same dose for at least 6 cycles (that's how long we hold doses on TR). If he drops below 90 (5) again, I'd reduce it again to 2.0 until you have some more data and understanding. On SLGS, we hold the same dose for 7 days and then do a full curve (testing every 2 hours for 12 hours) but since you're considering switching to TR, let's see where he is in 3 days.

If you do switch to TR, your reduction point drops to 50 (2.8) but for now, while you're gathering data, 90 (5) is going to be safer.

Also, Lantus does best when given at the same dose both AM and PM. It looks like you've been basing your dosing on the Pre-Shot numbers. Lantus dosing is based on how LOW it takes him with only a little consideration of the PS. Basically, lantus craves consistency.
 
Bounces are going to happen whether you're doing TR or SLGS. They're just a frustrating part of treatment but usually, as the cat stays in normal numbers longer, the bounces don't go so high and don't last so long.

If you're doing SLGS, you should have reduced Sam's dose. If they drop below 90 (5), you immediately reduce by .25.

You are lucky that yesterday morning Sam did OK....we don't recommend shooting that low until you have more testing data and a better understanding of how Lantus works (and how it works in YOUR cat because every cat is different --ECID)

I would reduce Sam to 2.25 and then hold that same dose for at least 6 cycles (that's how long we hold doses on TR). If he drops below 90 (5) again, I'd reduce it again to 2.0 until you have some more data and understanding. On SLGS, we hold the same dose for 7 days and then do a full curve (testing every 2 hours for 12 hours) but since you're considering switching to TR, let's see where he is in 3 days.

If you do switch to TR, your reduction point drops to 50 (2.8) but for now, while you're gathering data, 90 (5) is going to be safer.

Also, Lantus does best when given at the same dose both AM and PM. It looks like you've been basing your dosing on the Pre-Shot numbers. Lantus dosing is based on how LOW it takes him with only a little consideration of the PS. Basically, lantus craves consistency.

I had talked to my vet, who told me to shoot and monitor, which I did, given that i was home all day. So what exactly is the limit where I shouldn’t shoot? So we’ll just lower to 2.25, and i only change it if his mid day results are below 90. Got it.
 
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You might want to re-read the dosing methods sticky on TR and SLGS. With both methods, dosing is based on how low they are....the nadir's. (Even as long as I've been here, I still learn something or remember something I'd forgotten when I read that sticky).

Even on TR, until we have enough data and understand how our cat responds to food and insulin, we suggest stalling if you get a PS under 150. As you gain more data, the PS number you're willing to shoot starts to come down. Eventually, I got to where I'd shoot the scheduled dose for China if she was above 50 but that was only after a LONG time of learning, gathering data and learning about my girl. (as well as listening to the advice of the experienced folks that had been here before me)

Since you weren't testing when you were giving 3U, we really have no idea what was going on with Sam so we can't really say "because of this, that".

Luckily, the liver in our cats is sometimes our saving grace. If the BG drops too low or too fast, the liver releases stored sugars and hormones to bring the BG back up....that's what bouncing is. He could have been bouncing high, dropping low, bouncing high, dropping low that whole time. We'll never know but thankfully whatever happened during that time, Sam's still here!

From the SLGS dosing method:
How to handle a lower than normal preshot number:

Until you collect enough data to know how your cat will react, we suggest following the guidelines in the FDMB's FAQ Q4.4:
Q4.4. My cat's pre-shot level was way below the usual value. Should I give the injection?
A4.4. There's no hard and fast rule, but if you don't have data on how your cat responds to insulin, here are some general guidelines.
  • Below 150 mg/dl (8.3 mmol/L), don't give insulin.
  • Between 150 and 200 (8.3-11.1 mmol/L), you have three options:
    • a.) give nothing
    • b.) give a token dose (10-25% of the usual dose)
    • c.) feed as usual, test in a couple of hours, and make a decision based on that value
  • Above 200 (11.1 mmol/L) but below the cat's normal pre-shot value, a reduced dose might be wise.
  • In all cases, if you are reducing or eliminating insulin, it's wise to check for ketones in the urine.
  • Above the normal pre-shot value, give the usual dose, but if the pre-shot value is consistently elevated, it's a good idea to schedule a full glucose curve to see whether a change in dose or insulin is appropriate. In most cases, the target "peak" value should not be below 100 mg/dl (5.6 mmol/L), and for some cats it might be higher.
Keep in mind these are general guidelines, and they should be personalized to your own cat's response to insulin. If your experience is that your cat does not became hypoglycemic with a dose which is close to her usual, then personal experience should be your guide.

With experience, you may find that lowering these thresholds may work well for your cat. When you have reached that stage, the following guidelines are suggested for Lantus, Levemir, and Biosimilars users following the Start Low Go Slow approach:

If the preshot number is far below usual preshot numbers:
  • Do you need to stay on schedule? Then skip the shot.
  • Do you have some flexibility with your schedule? Then stalling to wait for the number to rise might be a good option. Don't feed, retest after 30-60 minutes, and decide if the number is shootable.
  • Repeat until the cat either reaches a number at which you are comfortable shooting, or enough time has passed that skipping the shot is necessary.
If the preshot number is near kitty's usual preshot numbers:

Look at your data to see what numbers you have shot in the past and decide what would be a safe, shootable number for your cat. Don't feed. Stall until kitty reaches the preshot number you've decided on and then shoot.
We usually don't suggest or recommend shooting a preshot number less than 90 mg/dL when following the SLGS Method. Remember that with SLGS, generally speaking, your goal is to achieve flat numbers that are greater than 90 mg/dL. However, let experience, data collected, knowledge of your cat, and availability to monitor help in making the best decisions for your cat.

If kitty is dropping faster or lower than you'd like, please see "Don't Panic! or How to Handle Low Numbers" and post for help or suggestions.
 
Here’s yesterday thread: https://felinediabetes.com/FDMB/threads/pre-shot-levels-of-72-help.271451/#post-3021480

as we explained yesterday, every time the bg falls under 90, your cat earns a .25 reduction. It doesn’t matter if it’s back to back. Also, can’t believe your vet said to shoot with a 72 preshot. I recommended a token dose but you had already shot. In order for members to give you accurate advice, please always link your previous thread so they can read through that as well. Thank you!
 
If you’re feeding dry food, aka the Purina ProPlan, you can’t follow the TR method. You need to stick with SLGS

@Chris & China (GA) he’s feeding dry and wet food

I really wouldn't consider the amount I feed him on average to be feeding him dry food. He gets it as a treat, maybe 5 or 10 pellets per day at most. I had to feed it to him yesterday because he will only eat dry food after he's bounced. For the last 2 weeks or so he's been 99% wet food, apart from yesterday when he would not eat wet food at all.
 
Here’s yesterday thread: https://felinediabetes.com/FDMB/threads/pre-shot-levels-of-72-help.271451/#post-3021480

as we explained yesterday, every time the bg falls under 90, your cat earns a .25 reduction. It doesn’t matter if it’s back to back. Also, can’t believe your vet said to shoot with a 72 preshot. I recommended a token dose but you had already shot. In order for members to give you accurate advice, please always link your previous thread so they can read through that as well. Thank you!

I started linking my previous threads when I make a new one on the Lantus forums. And yes; the vet said that he's been on 3 for over a month, so just feed him and monitor him and he'll be fine (given he was on 3 for a month without having any emergencies). She's been very hesitant to reduce his dose, she didn't seem thrilled that I had reduced it. Anyways; blood glucose curve today is looking fine. He should be okay on 2.25, maybe 2.0 depends on his night time levels at 4am.
 
It does not matter if you give Sam 2 pieces of kibble. It doesn't matter if the kibble is low carb (e.g., Young Again or Dr. Elsey's). TR is an aggressive protocol that was developed by a vet and is well researched. If you're going to follow the TR Protocol, you have to follow the protocol and it is very specific, your cat cannot be getting any dry food. The notable exception may be a freeze dried raw diet.

With both approaches to dosing, you also need to get at least one PM test. Numbers are often lower at night so you don't want to miss low numbers. In addition, if you don't get any PM tests, you're missing half of your data.
 
It does not matter if you give Sam 2 pieces of kibble. It doesn't matter if the kibble is low carb (e.g., Young Again or Dr. Elsey's). TR is an aggressive protocol that was developed by a vet and is well researched. If you're going to follow the TR Protocol, you have to follow the protocol and it is very specific, your cat cannot be getting any dry food. The notable exception may be a freeze dried raw diet.

With both approaches to dosing, you also need to get at least one PM test. Numbers are often lower at night so you don't want to miss low numbers. In addition, if you don't get any PM tests, you're missing half of your data.

Respectfully I can't see how say one pellet of dry food per day is going to do anything.

If giving him 5-10 pellets of dry food a day as a treat helps me test him, then that, IMO, is worth it compared to not being able to do TR. I measured it out, counted it by hand into a 1/8th of a cup measuring device, found that one cup has 1085 pieces of kibble in it. 605 kcals per cup means ~ 0.56 calories per piece of kibble. Out of that 18% by weight is carbs at most, I've done the math on this one before and it works out to be at most 18% by calories being carbs, so that's 5.6*0.18 = 1 calorie of carbs per day for 10 pieces. My current wet food is about 8% carbs, so really i'd be adding 0.56 calories of carbs per day. So if he eats 400 calories per day, and 8% of those are carbs, that's 32 calories of carbs per day. That's functionally equivalent to a 1.75% increase in the total number of carbs, or equivalent from going from a 8% wetfood to 8.14%. That is not going to result in a measurable difference in blood sugar levels, given that the uncertainty of commercial meters is +- 5-10%.

That's my logic anyway. I totally get where you're coming from though; if the protocol says no dry food then yes, ideally, no dry food. But I think you have to consider the effect that a miniscule amount of it will have compared to the rewards (which is that he doesn't fight me when I test him anymore; I just have to give it to him once per day and he's totally down to test; he sees a single kibble and he goes running for it like it's his last day on earth!).
 
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It does not matter if you give Sam 2 pieces of kibble. It doesn't matter if the kibble is low carb (e.g., Young Again or Dr. Elsey's). TR is an aggressive protocol that was developed by a vet and is well researched. If you're going to follow the TR Protocol, you have to follow the protocol and it is very specific, your cat cannot be getting any dry food. The notable exception may be a freeze dried raw diet.

With both approaches to dosing, you also need to get at least one PM test. Numbers are often lower at night so you don't want to miss low numbers. In addition, if you don't get any PM tests, you're missing half of your data.

That being said, if you really think that it's that important even at those levels of dry food, then I'll respect that and won't feed any dry food if doing TR. I do get where you're coming from; I also know Sam, and that kibble is like crack for him. He's so easily motivated with such a tiny amount of it. He'll come running for just like 2 or 3 pellets lol.
 
I understand your logic. The issue with TR is that it is an aggressive approach to dosing. As such, Jacqui Rand, DVM aimed to control as many of the variables as possible in order to maintain a safety net. The original version of TR was even more aggressive and the authors backed down because it wasn't feasible to get a cat started on the protocol at home -- it wasn't safe enough. Do I think people have modified TR -- probably. Would I support their doing so, probably not unless they had a great deal of experience and data related to managing their cat's diabetes.
 
That being said, if you really think that it's that important even at those levels of dry food, then I'll respect that and won't feed any dry food if doing TR. I do get where you're coming from; I also know Sam, and that kibble is like crack for him. He's so easily motivated with such a tiny amount of it. He'll come running for just like 2 or 3 pellets lol.
Would you be able to replace the dry kibble with a low carb treat like freeze dried meat? Purebites have a variety and are single ingredient so no carbs
 
I’ve been off the board for a while, but happened by your post. Waving to you from Calgary :). I’ve gone back through some history and I’m not sure if this will help you, but a general common theme in much of what was suggested by some very experienced people, revolved around data and how important it is. Setting aside for now the difference between TR and SLGS - if I asked you when Sam onsets, nadirs and what his typical duration is, what would you say? I often bring this up because I feel like it is truly key for each caregiver to learn the basics. Knowing how your cat responds to insulin and carbs has been ingrained in my journey and to me it really does matter! What my cat does with the same insulin and how sensitive he is or isn’t to carbs will not be the same as how Sam responds. Part of this whole process is learning:
  • Onset - the length of time before insulin reaches the bloodstream & begins lowering blood glucose
  • Peak/Nadir - the lowest point in the cycle
  • Duration - the length of time insulin continues to lower blood glucose
One of the challenges as Sienne pointed with dry food in the mix is how those carbs influence bg levels and for how long. To me, there are enough variables that I can’t control (how the insulin is absorbed among other things). Not every cycle will look exactly the same, so it’s up to you to figure out what Sam’s patterns are. Just my 2 Canadian cents for what they are worth.
 
I’ve been off the board for a while, but happened by your post. Waving to you from Calgary :). I’ve gone back through some history and I’m not sure if this will help you, but a general common theme in much of what was suggested by some very experienced people, revolved around data and how important it is. Setting aside for now the difference between TR and SLGS - if I asked you when Sam onsets, nadirs and what his typical duration is, what would you say? I often bring this up because I feel like it is truly key for each caregiver to learn the basics. Knowing how your cat responds to insulin and carbs has been ingrained in my journey and to me it really does matter! What my cat does with the same insulin and how sensitive he is or isn’t to carbs will not be the same as how Sam responds. Part of this whole process is learning:
  • Onset - the length of time before insulin reaches the bloodstream & begins lowering blood glucose
  • Peak/Nadir - the lowest point in the cycle
  • Duration - the length of time insulin continues to lower blood glucose
One of the challenges as Sienne pointed with dry food in the mix is how those carbs influence bg levels and for how long. To me, there are enough variables that I can’t control (how the insulin is absorbed among other things). Not every cycle will look exactly the same, so it’s up to you to figure out what Sam’s patterns are. Just my 2 Canadian cents for what they are worth.

Onset for sam is within an hour, sometimes 2, depends, probably closer to an hour and a half to two hours. Just last night within 2 hours he went from the 200's to 68 after 2.25 units.

Peak/Nadir; the blood glucose curve I did shows a normal nadir around 5-6 hours.

Duration: 12 hours, he can sometimes still be low in the morning from it, and his blood glucose curve shows a double peak/dip; he hits nadir, then it goes back up, then drops again before his next dose.

Your point about dry food is fair enough, I'll stop giving it as a treat. I'm going to stay on SLGS for now until I have him on a stable enough dose where he isn't going from hypo one day to hyper the next from the bounce. Vet suggested 2 units in the morning, 1.5 in the evening, and test hourly 4 times after his PM dose.
 
I wouldn’t say you are seeing 12 hour duration consistently and nadirs can, and do move around. Like I said, not every cycle will be the same, so what I found helpful is to look at the bg cycles over a period of a few days to see what the waves of action appear like. My main point too is that it takes more than 7 days of data, some of which were only half the picture (no data in pm cycle) to get a feel for what patterns can be seen.
 
I wouldn’t say you are seeing 12 hour duration consistently and nadirs can, and do move around. Like I said, not every cycle will be the same, so what I found helpful is to look at the bg cycles over a period of a few days to see what the waves of action appear like. My main point too is that it takes more than 7 days of data, some of which were only half the picture (no data in pm cycle) to get a feel for what patterns can be seen.
100% fair, i’ll wait at least another 3-4 weeks.
 
So update: i’m getting more used to everything, sams been dx’d since august. I read regulating them by 6 months improves remission odds. I test a lot now, willing to change my sleep schedule to test on days i work in the office.

I’m tempted to switch over to TR. we need to regulate him within a couple months. I have over 2 weeks of data now, he’s on 1 unit now.
 
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