For anyone who is interested in Budesonide, I read the most interesting post this morning on another group. I’m going add it below.
@PerfumedCatMom @Tina Marie and Jan
Here it is:
“Just to clarify, Budesonide is a steroid. Budesonide is also called Entocort EC. It's a human-grade med that's often prescribed for people with IBD or Crohn's disease. This med comes in capsules where inside there are about 300 tiny little granules. Each granule has a special coating so that the med doesn't dissolve in the stomach but actually dissolves in the lower part of the small intestine where the inflammation is actually occurring. This "targeted" therapy happens because the coating is pH sensitive. As food and meds go through the body, they go down the food tube (esophagus) and hit the stomach where it's acidic because acids are needed to break down food and meds. This acid environment has a low pH. As food and meds move through the stomach to the small intestine and eventually the large intestine, the area is less and less acidic so the pH level goes higher. Entocort EC granules have a coating that dissolves only after it hits the higher pH found in the small intestine.
When a pharmacy compounds Entocort EC, they open the capsule and crush those 300 little granules. In doing so, that pH coating on each granule is destroyed. That means that the med starts to break like most other meds instead of waiting until it gets to the actual area of inflammation in the small intestine. Because the pharmacy takes the granules out of the capsule and eliminates the pH coating, it's really not the original Entocort EC anymore but just some crushed Budesonide.
When you're giving your cat the compounded Budesonide, it still goes into his system and it will have a generalized anti-inflammatory benefit as steroids are supposed to do. But if you give the Budesonide in its original form as Entocort EC, the steroid is designed to work specifically at the area of inflammation and therefore may be much more efective.
As I said, Entocort EC is human med and comes on a capsule. Each capsule is usually 3 mg and that's typcially the human dose given once a day. Inside the capsule are those 300 or so little granules. You can give Entocort EC to a cat. The cat dose is usually 1 mg or about 100 of those little granules. For my cat, I used to open the capsule and then simply divide the granules into 3 little piles. I then put each pile into a #5 gelcap. Instead of having to go to a specialty pharmacy, the vet can call in a prescription for Entocort EC to a Walgreens or a Walmart pharmacy and have the vet specifically ask for the "generic". With a GoodRX coupon, you can buy thirty (30) 3 mg capsules for about $30. Since the cat dose is just 1 mg, thirty 3 mg capsules become ninety (90) 1 mg capsules. For a cat, that's a 3 month prescription for about $30”