9/4 Ruby AMPS 262/+3 242/+10 262/PMPS 234/+3 162

Katherine&Ruby

Katherine&Ruby

Member Since 2020
Yesterday.

Seems like fall weather has made an early appearance. Kitties are enjoying the open windows and the cool breezes coming into the house. Ruby has been a good girl, eating her foods, pooping a little more frequently and generally being a sweet cuddle monkey.

Hope everyone has a beautiful Caturday! :bighug:

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Afternoon Katherine, I just want to sick that face of hers :p I know I'm a sick person :pShe's just too darn cute!
I'm glad to hear she's eating good and pooping more often.
I hope you all have a nice day :bighug::bighug:
 
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PerfumedCatMom said:
Yesterday.

Seems like fall weather has made an early appearance. Kitties are enjoying the open windows and the cool breezes coming into the house. Ruby has been a good girl, eating her foods, pooping a little more frequently and generally being a sweet cuddle monkey.

Hope everyone has a beautiful Caturday! :bighug:

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That's a lovely photo. I think it would make a great painting. I have a friend who is an artist of some reknown, who could paint Ruby well from that photo (and add in other items of interest) probably not up to your art standards, Katherine (and definitely not modern) but for those of us who have a small place in our homes for cat art, very heart-warming!

I'm so happy Ruby and Olive are doing so well. I hope you have an enjoyable weekend, Katherine and Frank (and I hope no water in your basement.)
 
Suzanne & Darcy said:
That's a lovely photo. I think it would make a great painting. I have a friend who is an artist of some reknown, who could paint Ruby well from that photo (and add in other items of interest) probably not up to your art standards, Katherine (and definitely not modern) but for those of us who have a small place in our homes for cat art, very heart-warming!

I'm so happy Ruby and Olive are doing so well. I hope you have an enjoyable weekend, Katherine and Frank (and I hope no water in your basement.)
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I love this photo of Ruby! Frank took it. I adore the expressiveness of Ruby's eyes. Please PM me the name of your friend! I have been wanting to get portraits done of my cats for the longest time, but I've been so very picky about the style that it's done in that I have never found the right kitty portraitist. Cat art is one of the most popular genres in all of art history. I did a search for cat images on Google, it's so much fun! https://artsandculture.google.com/entity/cat/m01yrx?hl=en

We are still drying out our basement and we're under orders to boil our water but others in the area have had it way worse so I'm grateful. Thank you for worrying about us, Suzanne!
 
PerfumedCatMom said:
We are still drying out our basement and we're under orders to boil our water but others in the area have had it way worse so I'm grateful.
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Ugh! Been long enough. No wonder Ruby is on the stairs to the highest point in the house. Fall weather here means laps. :)

I know you said you want Ruby off of steroids, but as you know already, budesonide does not impact the BG as much, or at all. ECID of course. Of course, going on chlorambucil without would be better.
PerfumedCatMom said:
She also said that there is no evidence that giving chlorambucil won’t cause another kind of cancer as it helps to quell this one.
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Would love to see the vet's research or data on number of chlorambucil kitties who get another kind of cancer, that is in fact caused by chlorambucil. Even kitties who are diabetic or have CKD or just plain older have no guarantee of not getting another type of cancer. I been on the groups.io SCL group for over 5 years now, and I haven't seen an extraordinary amount of secondary cancers beyond what I see in FDMB.
 
Wendy&Neko said:
Would love to see the vet's research or data on number of chlorambucil kitties who get another kind of cancer, that is in fact caused by chlorambucil.
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Today, I read the entirety of the paper that she co-wrote on SCL becoming LCL in a small sample of 9 cats who received chemotherapy through her hospital over the course of 10 years. What was found was that their median age was 11.4 years old (Ruby is 11.5 years old), relatively young for cats with SCL, and there is a possibility that receiving chemo at that age contributed to a secondary malignancy that is apparently also found among younger human patients with lymphoma receiving chemotherapy. Although 9 cats is not enough of a sample, and since they were all from the same hospital they have possibly shared similarities with geography, environment, etc., it's not the strongest study, but it's been published nevertheless and could be the reason for her hesitation.
 
My understanding is that the cats on that study were on the every other day dosing of chlorambucil, which is a much larger dose than the every other week dosing. More chemo might have more side effects. I've also seen that one if five cats gets cancer, and 1/3 of all cancers are lymphoma. So that means roughly 7% of all cats get lymphomas. The article you linked found a second malignancy in 9.9% of cats with small cell lymphoma, not much different than the standard cat population. And well within variation given size of population tested.
 
PerfumedCatMom said:
Today, I read the entirety of the paper that she co-wrote on SCL becoming LCL in a small sample of 9 cats who received chemotherapy through her hospital over the course of 10 years. What was found was that their median age was 11.4 years old (Ruby is 11.5 years old), relatively young for cats with SCL, and there is a possibility that receiving chemo at that age contributed to a secondary malignancy that is apparently also found among younger human patients with lymphoma receiving chemotherapy. Although 9 cats is not enough of a sample, and since they were all from the same hospital they have possibly shared similarities with geography, environment, etc., it's not the strongest study, but it's been published nevertheless and could be the reason for her hesitation.
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How did they determine that chlorambucil was the cause of the progression to LCL? Can it not be that LCL is a progression from SCL if the cat lives long enough with SCL? Just like it is believed (by many vets) that IBD progresses to SCL? I only read the abstract so far… not the whole study… so I am wondering.
 
Suzanne & Darcy said:
How did they determine that chlorambucil was the cause of the progression to LCL? Can it not be that LCL is a progression from SCL if the cat lives long enough with SCL? Just like it is believed (by many vets) that IBD progresses to SCL? I only read the abstract so far… not the whole study… so I am wondering.
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There was no control group of cats who did not receive chemo to test this hypothesis. This was a retroactive study rather than one that was planned from the get go. I wonder though if Ruby’s case is mild enough that she is buying time. Another thing the paper said was that these cats who had SCL that then developed LCL had thickness in the ileum and duodenum, whereas Ruby has hers in the jéjunum where the majority of cats with SCL has it. So again these cats were outliers in terms of previous studies on cats with SCL.
 
PerfumedCatMom said:
There was no control group of cats who did not receive chemo to test this hypothesis. This was a retroactive study rather than one that was planned from the get go. I wonder though if Ruby’s case is mild enough that she is buying time. Another thing the paper said was that these cats who had SCL that then developed LCL had thickness in the ileum and duodenum, whereas Ruby has hers in the jéjunum where the majority of cats with SCL has it. So again these cats were outliers in terms of previous studies on cats with SCL.
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Thanks. It’s all so complicated, isn’t it! And we just want to do what’s best for our cats and sometimes it’s hard to know what that is. I’m going to read the whole thing. Thanks for linking it.
 
Happy Sunday to you and Ruby:bighug:

Civvie Molly did not have a biopsy. Since it would be a month at least for biopsy, I opted to start her on Prednisolone now because of the inflammation in her liver and gallbladder. I was told her liver and gallbladder were angry, and her colon thickened (jejunum). Just wanted to answer you on the biopsy question. We are dealing with IBD and/or possible LSA according to the sonographer. Ursidiol was given for gallbladder and liver, but Molly throws up all her food 5 hours later. Still hoping the prednisolone increases appetite. This is rough. With a few answers come many more questions.

None of our issues are just like Ruby's (likely worse) BUT I have learned some very helpful things through your experiences. I was learning through you, long before I knew about Molly's issues. I may decide to post in Health, because I won't intrude on Ruby's condo again. Just wanted to thank you for loving and learning so much for your gal!! Healing vines coming to you:cat::)
 
Oh my dear Jan! I'm so sorry that you're going through this with Molly. I really hope the prednisolone makes Molly feel better. It has greatly improved Ruby's symptoms. She's eating like a little piggy, nudging me for food every few hours, and she's holding it all down for the most part. I eradicated turkey from a certain pet food purveyor from her diet and that seemed to have improved things. Did you try her on a novel protein yet? For a long time we thought it was either IBD or SCL as well, and that's when I started the transition to raw food so that I could see her reaction to different proteins without the additives in commercial foods that could have also irritated her system. Sadly that did not work, and now with the SCL diagnosis we know why, because she would have responded if it was just IBD. Since you're starting her on the prednisolone though you won't be able to do a biopsy as it would muddy the picture. Sorry I don't know much about livers and gallbladders to help you there, but I bet lots of members on the Health forum could chime in.

Big hugs to you Jan! I feel for you! :bighug:
 
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