6/29 Snuggie: PMPS 292; +8 153; +10 135 ((AMPS 97; +1 149; +3 194; +5 184; +7 251; +9 279

He seems to be kinda flat from +9. Cats on Levemir often nadir at the end of the cycle. Will you be able to monitor if you shoot?
 
Yea. I’m gonna test now (20 min past shot time) and can monitor all day
Then you can shoot. :-)
Sometimes cats go lower when stalling without food. If you are following TR (?), you can shoot any number over 50 once you have enough data on your cat and provided you can monitor.
 
The other thing to remember is that with a depot insulin, the insulin doesn't start working immediately. Since it's the end of the cycle, there's limited insulin to influence the numbers and it will take several hours for the dose to start working. In addition, you're feeding your cat which also causes numbers to rise.

If you're still feeding Young Again, you need to be using SLGS as your dosing method.
 
Ok he was at 97- I shot and will monitor visually; when do you recommend I grab BG readings?

(ETA: if I was not able to monitor, should i have stalled further?)

With @Wendy&Neko ‘s blessing, we are following a TR approach since being Dx last Thursday as an acro-cat and since he’s getting VERY limited amts of Young Again. (@Bandit's Mom and @Sienne and Gabby (GA) you may have missed that post, so filling you in. Cabergoline on the way.)
 
If you're going to stall, you do not want to feed. If you feed your kitty, the numbers will be inflated due to the food vs the numbers rising because it's the end of the cycle.

If it were me, I'd get a +1 just to be sure what direction the numbers are going At some point soon, I'd encourage you to plan on getting a curve. From the data you have, especially with the greens yesterday, there's no way to tell when onset and nadir are occurring If you're going to be shooting lower numbers, having that information is important. It's looking like nadir may be around +8 but it's helpful to be able to see the whole picture. Whether to stall or how long is a bit of an art vs a science. Up to a point stalling is OK but if you end up stalling for too long, it throws your entire schedule off.
 
If you're going to stall, you do not want to feed. If you feed your kitty, the numbers will be inflated due to the food vs the numbers rising because it's the end of the cycle.

If it were me, I'd get a +1 just to be sure what direction the numbers are going At some point soon, I'd encourage you to plan on getting a curve. From the data you have, especially with the greens yesterday, there's no way to tell when onset and nadir are occurring If you're going to be shooting lower numbers, having that information is important. It's looking like nadir may be around +8 but it's helpful to be able to see the whole picture. Whether to stall or how long is a bit of an art vs a science. Up to a point stalling is OK but if you end up stalling for too long, it throws your entire schedule off.
I was thinking a +1 today is a good idea. I may as well do the curve today, but this doesn’t seem like a typical cycle for him… . I’m really surprised how he’s handling this dose after not seeing much improvement at 7.5, and we will just be doing this dance again when the cabergoline gets here.
 
There's a good chance Snuggle may bounce and, as a result, the curve won't be typical. Sometimes, you hit a "good" dose and magic happens. Let's hope that's the case.
 
I would have shot... but it took me a long time to get to the place to know it was okay to do that and feel comfortable with it! I knew that with food he would go up. I knew that it would take a few hours for the shot of Lev to kick in, too. I hope you have a good day.... going to check that SS now! I second what Summer said... think about how far you have come!
 
@Sienne and Gabby (GA) thank you for the reminder to not feed. It’s funny, we read and think we know what to do in this situation but when it happens, it seems it all flies out the window! Once I’m thru today’s latest crisis LOL, I’m going to make a cheat sheet and tape it near our supplies closet, our meds closet, and in the hypo kit, and probably a few other places. :cat:
 
Over time and with data, shooting green does become easier. Especially once you know he's on his way up and you know onset isn't for hours. By the way, there is something that goes with shooting your first green:
Balls_of_Steel_%28video_game%29.jpg

On a more serious side, you need to think some more about what you want your reduction point to be both now, and when cabergoline is on board. The goal with acrocats is not to force reductions, that'll happen on their own or not as it's not about a healing pancreas. TR was a good way to get you increasing quicker to a dose seeing good numbers. My goal was to try to keep Neko in numbers under renal threshold, as much as possible. That number can vary by cat, but was around 220 for Neko. When reductions were coming fast and furious after radiation therapy, I raised the reduction point to 70. It just gives a little bit of a safety margin for higher dose (and higher depot) cats making sudden changes. I have seen some cat on cabergoline also go down dose fast.

So the question for you is, where would you like the nadirs to be? It make take some experience to find out what works for Snuggie. After all, this is rather new to both of you! :D
 
Over time and with data, shooting green does become easier. Especially once you know he's on his way up and you know onset isn't for hours. By the way, there is something that goes with shooting your first green:
Balls_of_Steel_%28video_game%29.jpg

On a more serious side, you need to think some more about what you want your reduction point to be both now, and when cabergoline is on board. The goal with acrocats is not to force reductions, that'll happen on their own or not as it's not about a healing pancreas. TR was a good way to get you increasing quicker to a dose seeing good numbers. My goal was to try to keep Neko in numbers under renal threshold, as much as possible. That number can vary by cat, but was around 220 for Neko. When reductions were coming fast and furious after radiation therapy, I raised the reduction point to 70. It just gives a little bit of a safety margin for higher dose (and higher depot) cats making sudden changes. I have seen some cat on cabergoline also go down dose fast.

So the question for you is, where would you like the nadirs to be? It make take some experience to find out what works for Snuggie. After all, this is rather new to both of you! :D

yay! Balls of steel!! So you anticipated my line of thought here and got to some concerns. I’m glad to know he’s capable of these numbers but YES i wondered about unexpected drops given acro - esp once cabergoline is onboard and yesterday and today were a little bit too close to 50 for my comfort level given all that. I definitely want a safety margin so I’m not doing this dance every day lol!! I think I’m still kinda new to these numbers and acro and we have no clue how he will do on “cab” - I’m thinking maybe 90 to start? Not sure about the upper threshold but since he’s CKD I do want to consider the renal threshold. Feel free to make a suggestion once we complete today’s curve…
I have yet to read the article you linked to me regarding acro and kidneys (and many others from yesterday; too busy dealing with all the unexpected greens hahaha) but I promise I will!!
 
So the tricky part about how low you want to see Snuggie go is what it does to the rest of the cycle. With Neko, if her nadirs were in the 70's, she's stay under renal threshold. Above that, and she wouldn't. It's hard to pick a band of numbers you'd like to kitty to stay between, and dose to meet that. It will take some experimentation on your part to see what works for Snuggie. But definitely ECID. If you look at Amethyst's SS, she can stay really flat and blue.

The other thing you can play with now is size of dose changes. Only we typically change by 0.5 units at a time over 5 units, some cats are sensitive to small changes. Again, Neko was. You could try doing a 0.25 unit reduction and see what it does to Snuggie's nadirs. The other thing to keep in mind, there is more than one reason an acros dose needs can go down. If he was seeing glucose toxicity from the higher numbers, he could break through and need to go down a bit. The tumour could wane a bit. And once you start Cabergoline, you will have to be very conservative. Higher reduction points if following TR, extra large reductions, skipping doses, BCS (partial doses) are all tools you'll need in the toolkit to keep him safe. Maybe - ECID. :p
 
So the tricky part about how low you want to see Snuggie go is what it does to the rest of the cycle. With Neko, if her nadirs were in the 70's, she's stay under renal threshold. Above that, and she wouldn't. It's hard to pick a band of numbers you'd like to kitty to stay between, and dose to meet that. It will take some experimentation on your part to see what works for Snuggie. But definitely ECID. If you look at Amethyst's SS, she can stay really flat and blue.

The other thing you can play with now is size of dose changes. Only we typically change by 0.5 units at a time over 5 units, some cats are sensitive to small changes. Again, Neko was. You could try doing a 0.25 unit reduction and see what it does to Snuggie's nadirs. The other thing to keep in mind, there is more than one reason an acros dose needs can go down. If he was seeing glucose toxicity from the higher numbers, he could break through and need to go down a bit. The tumour could wane a bit. And once you start Cabergoline, you will have to be very conservative. Higher reduction points if following TR, extra large reductions, skipping doses, BCS (partial doses) are all tools you'll need in the toolkit to keep him safe. Maybe - ECID. :p
Woo boy what has this cat gotten me into? HA! OK, so the safe nadir depends on the highest number in the cycle… got it. Well let’s see what he does in the next cycle or two. I’m gonna polish up on how dose reductions are earned - and some other TR basics - just to inform myself.

in the meantime - where can i find the visual guide to quarter doses? Or should I just get calipers? Those syringes give me fits when trying for an exact dose ON a line - let alone between one. (I do find they’re easier in warmer weather).
 
The visual on doing quarter doses is here, but definitely get calipers. You'll wonder how you ever dosed without them. It's real fiddley at the beginning, it took me a long time to get used to them, but I was amazed at how badly the lines on syringes are printed and how much variation there can be from syringe to syringe. Calipers help you throw all of those problems out the window to create beautiful, consistent doses. :)
 
The visual on doing quarter doses is here, but definitely get calipers. You'll wonder how you ever dosed without them. It's real fiddley at the beginning, it took me a long time to get used to them, but I was amazed at how badly the lines on syringes are printed and how much variation there can be from syringe to syringe. Calipers help you throw all of those problems out the window to create beautiful, consistent doses. :)
Whoa!! Ok thanks! I’m making a reading list to tackle once he figures out what he’s doing - we are now bouncing - no surprise there!
 
Woo boy what has this cat gotten me into? HA! OK, so the safe nadir depends on the highest number in the cycle… got it. Well let’s see what he does in the next cycle or two. I’m gonna polish up on how dose reductions are earned - and some other TR basics - just to inform myself.

in the meantime - where can i find the visual guide to quarter doses? Or should I just get calipers? Those syringes give me fits when trying for an exact dose ON a line - let alone between one. (I do find they’re easier in warmer weather).
If you look at my spreadsheet, I plan to hold this dose for a little while, maybe one more increase. I like Wendy's 70 cutoff for Mr Kitty, though I'm considering 2x below 70 because every so often he'll throw a lower number but not again, and I end up needing to increase.

I had hoped to keep him under 150 overall but not looking quite possible with the reduction at 70. Maybe he'll surprise me. Just hoping to keep him out of yellow, that's when we start having trouble with litterbox usage.

Edit: reminds me I need to call on that darn cabergoline should have been here by now. I'm not sure how that will affect things, which is why I'm ok with these 80 nadirs for now. Though I believe I read it can take 5-6 weeks to start showing any improvement
 
If you look at my spreadsheet, I plan to hold this dose for a little while, maybe one more increase. I like Wendy's 70 cutoff for Mr Kitty, though I'm considering 2x below 70 because every so often he'll throw a lower number but not again, and I end up needing to increase.

I had hoped to keep him under 150 overall but not looking quite possible with the reduction at 70. Maybe he'll surprise me. Just hoping to keep him out of yellow, that's when we start having trouble with litterbox usage.

Edit: reminds me I need to call on that darn cabergoline should have been here by now. I'm not sure how that will affect things, which is why I'm ok with these 80 nadirs for now. Though I believe I read it can take 5-6 weeks to start showing any improvement
Oh thanks! You really have a lot of PM data (and beautiful colors!) - do you mind if I ask what your shot times are? Also what do you mean by 2x below 70?

I know what you mean about seeing a surprise low number that’s never repeated - that happened a lot to us. I’m hoping today we are seeing a bounce and not an indication that we need to go higher, but it is what it is.

what’s the issue with the delay with the cab? My vet didn’t give me an eta on it but if it’s not here by Friday I’ll give them a ring. I need more sub q fluids anyway LOL!
 
BOING!
Please just let us stay out of the pinks. I’m enjoying only having to scoop the litter 3x a day - altho I admit I’m paranoid he’s going “elsewhere” :eek:

Edit - he has had some pumpkin today due to being constipated so that could be helping the higher numbers …
 
Oh thanks! You really have a lot of PM data (and beautiful colors!) - do you mind if I ask what your shot times are? Also what do you mean by 2x below 70?

I know what you mean about seeing a surprise low number that’s never repeated - that happened a lot to us. I’m hoping today we are seeing a bounce and not an indication that we need to go higher, but it is what it is.

what’s the issue with the delay with the cab? My vet didn’t give me an eta on it but if it’s not here by Friday I’ll give them a ring. I need more sub q fluids anyway LOL!
Shot times are usually 8a/8p, but I also don't work. My husband and I split PM test duty, and I usually grab a test if I wake up in the +5 to +8 range.

2x below 70 means that I'll reduce once he goes below 70 two times, on different cycles (possibly different days, I'm not sure what will work for him yet). Normally you'd reduce as soon as they go below your reduction threshold one time, but I just get the feeling a reduction wouldn't stick if I did it that way (unless he went very low).

Idk what the issue is with the cab. Vet ordered it two weeks ago, they were going to compound it in-house, he thought it would be ready last week
 
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