10/06/18 Texas Gizmo PMPS=79, +2=158, +4.5=144

LizzieInTexas

LizzieInTexas

Member Since 2016
10/05

AMPS=118

Still not eating good. Seems very painful. Am going to give him pain meds as soon as I can get him to eat a bit more of his PS food. I just don't know what to do for him. Maybe a half Ondan too? IDK.

Really hoping I get the BW results today.

Happy Caturday.
 
Broke down and gave him tuna cat food. After trying 5 different foods - he is finally eating something. I hate doing it but I have to keep him eating. Gave him 1/2 Canna and 1/2 Ondan when I tested at +3.
 
LizzieInTexas said:
I have buprenorphine from 2/2018.
Click to expand...

I think it depends on how it's stored and how it was compounded
Do you have vials or are they in prefilled syringes?
I found thiis, it makes an interesting read
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517336/

In prefilled syringes it deteriorates very quickly and anything you have from feb 2018 wouldn't be potent.

In glass vials stored in fridge over 180 days there was 10% loss in potency, (this is me just having a very quick read through BTW)

This was the summary of the above article
In summary, the dilution of a manufactured drug is considered pharmaceutical compounding. As such, a BUD should be assigned according to available information regarding the stability of the specific preparation, general recommendations listed in the USP, and the risk of microbiologic contamination for sterile preparations. Buprenorphine diluted 1:10 with 0.9% bacteriostatic saline and stored continuously in glass vials at refrigerated and room temperatures in the dark remained above 90% of initial concentration and microbiologically stable for 180 d. The concentration of diluted buprenorphine stored in plastic syringes decreased rapidly at both refrigerated and room temperatures. Therefore, we consider it inadvisable to use plastic syringes as storage containers for this compounded preparation. Further investigation is needed to determine the toxicologic and therapeutic stability (efficacy) of diluted buprenorphine. Sterile, single-dose injectable formulations of buprenorphine are commercially available in countries outside the United States. We believe the results from our study may apply to those formulations as well, given the similarity in composition. However, because multidose formulations often contain preservatives, our findings should not be generalized to include dilutions of such formulations. In addition, preparations of buprenorphine diluted into sterile water or 5% dextrose in water require separate inquiries into their stability characteristics to support longer BUD than those recommended by the USP
 
Gill & George said:
think it depends on how it's stored and how it was compounded
Do you have vials or are they in prefilled syringes?
Click to expand...
This is it. Not stored in refrig.

download_20181006_094520.jpg
 
Is it branded? like it came from manufacturer that way? It looks like a container that the vet might have used.
Or do you think vet put it in that container himself?

I'm reading that once seal has been breached on a multidose vial, like simbadol, it will only last 28 days, but if it hasn't been breached then it has 21months.
But if vet put it in there...... I'm thinking it probably will have lost significant potency.



https://www.zoetisus.com/products/cats/simbadol/pdf/simbadol-faq.pdf (but you haven't got the original packaging for this, vet might have compounded it himself or had it made)
 
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