5/24 Carter - Last PMBG 83, but Carter isn't doing so well... please read! :(

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Erica & Carter

Member Since 2016
Hi everyone,

Long time no talk, sorry about that. Our move across the country took a lot of my attention, but we are finally settled in beautiful Seattle, WA and I'm very happy to be closer to home in Vancouver, BC.

So, this might be long, but I'm a mess and would love some advise...

Carter has been in remission for nearly 11 months now, which is great, but now some other health problems have come up.

Back up to about 8 months ago, where Carter started experiencing some acute vomiting usually no more than an hour after meals, and it was first chalked up to transitioning him to raw. Then next assumed to be food intolerance and possibly a scarf/bar deal, so I changed him to novel protein canned food and got a slow feeder, which I don't think made a difference either way. I decided to go with EZ Complete and cook his food, which, if my memory serves me correctly, he did really well on (maybe one case of vomiting over 3 months?) but I was struggling financially due to this move, and decided to put him back on high quality canned: tried Weruva, but he would have some more vomiting issues with that, then I tried Bravo canned (no carra., no gums) and he has been doing pretty well on it comparatively, until this month the acute vomiting has become more frequent.

Now before we moved from AL to WA, IBD was considered a possibility, but I wanted to establish care up here first before attempting to explore that option - which I did, as I now work for a specialty veterinary hospital. So I had signed all my animals up for pet insurance a few weeks ago, but since they were all slightly overdue for their annuals, they needed to come in anyway to establish care and a baseline of health for any pre-existing conditions. I knew I wanted to bring Carter in any way, and I know he has pre-exiting conditions, and had possibly more issues brewing, so I knew going into the appointment there would be more things that could surface that he won't be covered for. I'm likely going to switch his insurance to accident/emergency only, as he has too many pre-existing conditions for it to be worth it. But anyways, that wasn't my main concern, as I noticed other symptoms occurring over the past few weeks that had me alarmed. He has hairloss on his ears, weight loss, loss of fur quality, ravenous hunger and of course, the acute vomiting continues. I had been wanting him to be seen regarding the IBD, but now of course I'm thinking he has to be hyperthyroid. We ran a full senior panel on him and I got the results last week.

ALT was 671, up from 234 in 2016, and 42 in 2014.
T4 was 3.8, up from 1 in 2016, and 1.8 in 2014.

We ran of TSH and a free T4(which I know now is kind of useless/old way of determining hyperT) and go those results yesterday.
TSH is less than o.03
Free T4 was 30

TSH is indicating hyperthyroidism, while the free T4 is not - which is more than likely, a false negative as the Feline Hyperthyroid Center has basically said that we should be looking at the TSH, not the free T4 for determination - and that looking at the free T4 is more of an old school approach.

Given that he is in the high grey area of hyperT, and symptomatic, I believe we are going to be starting the Methimazole - low dose.

Now, regarding his high ALT, it was recommended that we do an abdominal ultrasound, which we did, on Monday. Results were inconclusive, but did show the liver being coarse with some abnormalities, but no obvious masses, and NO evidence of IBD. Intestines were completely normal, and I was speaking to the ultrasonographer who kindly did this ultrasound for me for free being I'm an employee, and he didn't see any evidence to support IBD, not even slightly or he would have suggested a biopsy. I know a biopsy is the only way to determine for sure, but his thoughts are the same as mine - the acute vomiting is due to the hyperT. He's never had issues with diarrhea either, to warrant more evidence towards IBD.

For the liver, we are going to support it with Denamarin and first treat with antibiotics to rule out a bacterial infection. Re-test in 4-6 weeks, and if no improvement or it worsens, opt for a biopsy of the liver. I'm not sure if we are going to start treating with a low dose of Methimazole along with the antibiotic and Denamarin, as the treatments could conflict with each other and prevent us from seeing if the liver is being treated properly, or if they want to treat the liver first and wait 1-2 months before starting Methimazole. The high ALT could also be related to the hyperT, so it's possible by treating the hyperT, the liver values will improve.

To top it all off, he has reoccuring conjunctivitis in both eyes that we are treating with an antibiotic gel, but we don't know if it is flared up by seasonal allergies or not, causing him to scratch his eyes, and reinfect himself with bacteria, etc. So that was another question - does he need to see a dermatologist? He's used similar gel for his eyes before, which works temporarily to heal, but then comes back... so I guess we will see once this dose is done.

Regarding the i131 treatment, I'm not sure how soon I'd be able to afford that - I know he isn't in "abnormal" numbers yet but just thinking ahead. I'm fortunate that by working at a veterinary practice I have got most of this treatment discounted, some things even free, but for things like the i131 or a dermatologist, I'd have to seek treatment at another practice, where I wouldn't be lucky enough to get a discount and be able to pay my remaining bill over time where as I can at my job thanks to my lovely practice manager.

So basically Carter is being riddled with a few different illnesses and I guess I'm feeling overwhelmed. Diabetes, hyperT, conjunctivitis, possible allergies, etc. On the bright side his kidneys looked great and he still is crystal free in his urine!

Now, before the hyperT diagnoses, I had been wanting to try him on the SEB/George's/Probiotic slurry 20 minutes before a meal, to see if that would help with the vomiting/regurgitation, but now I'm thinking if it's due to the hyperT, reducing acid build up won't help or prevent it from happening right? I used to give SEB with food and didn't notice a difference, and with so much going on I don't want to put effort into a supplement that won't really work for his specific case. I know the 2 hour rule with SEB due to absorption issues, but now I'm paranoid about giving it to him at all, I just want to make sure he is getting his medication properly and I don't want to alter the results in any way. Also I'm not yet sure of his medication schedule, but I don't think giving him the slurry will be feasible anyways as I'd have to wake up at 4am, and I wouldn't be home to give it for dinner. I work 12 hour shifts so the timing is just hard. He eats 3 meals a day (would benefit from 4, as sometimes the regurgitation I feel is due to the meal being too large) but even with an autofeeder, I can't make it happen because he will be eating cooked, and my others will be eating raw. Also, I know it's pointless to be giving probiotics with antibiotics as they cancel each other out so to speak, but I SHOULD be giving S. Boulardii to help prevent any diarrhea from the antibiotics, correct? And the continue with the probiotics after the antibiotics are finished?

How much S. Boulardii should I be giving? For the probiotics, I was giving 1/8 tsp twice daily of the Wholistic brand for cats, maybe I should go back to human grade though, the Renew brand. I think I did 1/2 capsule twice a day.

Should I look out for anything specifically that could cause his BG to rise regarding medication for any of these issues?

My plan is to switch him back to the EZ Complete with cooked, and regarding meds/supplements... I'll have to see what our plan is on Friday. I know roughly what we are going to be giving, but timing and scheduling is up in the air.

I feel like my head is spinning. I just want to do the best I can for him. We have actively been trying to keep his weight down, as he was obese and over 20+ when we adopted him two and a half years ago, but now he is 10 pounds and too thin I feel for his size. I don't want him to lose anymore weight, and want to get the vomiting under control. If anyone has any input, advise, thoughts, experiences they would like to share, I'd appreciate it.
 
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Hi Erica - that's quite a story there
I don't have any experience with hyperthyroidism but I"m just wondering if all/most of the symptoms can be explained by that - what does the vet say?
 
Hey Erica, I am so sorry that Carter is having so many issues and I can imagine your head spinning for sure. Before I even finished reading your post where you got to the labs I thought hyper T as it sounded just like my civvie Forrest before he was DX last year. Losing weight, starving hungry, and very very needy, always wanting attention ( apparently that is one of the signs too) . He also would scarf and barf often before I got him on the Methimazole and I just thought it was just that, scarf and barf but apparently, frequent vomiting is another one of the symptoms. Since we started on the Methimazole, that has slowed down appreciably , it might only happen once a month or so.

Forrest's levels before DX was just slightly over normal so it was caught soon and @Marje and Gracie recommended that I do not start him on 1/2 of a 5mg. pill twice a day as most vets with RX but to give him 1/2 of that; I cut the pills into quarters and gave him a 1/4 tab twice a day. Apparently, starting on the higher dose is old school and a lot of kitties are then thrown into Hypothyroidism and then the meds have to be stopped for a while till levels level out. I followed her suggestion and when I took him back in 3 weeks to test his levels , I told the vet that I had only given him 1/4 pill twice a day and his levels were just perfect! So that is still his dose.

After Carter starts on the methimazole , perhaps you won't even have to consider given the SEB at all especially since there is no diarrhea. Maybe a better idea would to give a digestive enzymes and probiotic daily instead. My civvie gained back his weight shortly after he got stable on the methimazole so, I hope that will happen for Carter as well as it sounds you are very concerned with his thinness.

@Marje and Gracie is the one here who is a wizard with labs interpretation so hopefully she will be able to help you. I don't know if the meth impacts BGs or not. It is a common thing for FD's to have Hyper T as well.

It is good to hear from you despite the issues at hand and glad your move there has been a good one for you.
 
Hi Erica.

It's great to hear from you, and I'm happy that Carter's FD is still in remission, but I'm sorry about all the other issues. I don't really have any input for you, except to offer you vines and prayers for answers and improvement. Knowing that it's NOT IBD or intestinal lymphoma is certainly good news, as that was the first thing I thought when I started reading.

I was going to tag Marje, but I see someone beat me to it. If anyone here can give you good feedback, it's Marje.

Congrats on the new job. Sounds ideal, given Carter's issues.

Please keep us posted!
 
Hi Erica - that's quite a story there
I don't have any experience with hyperthyroidism but I"m just wondering if all/most of the symptoms can be explained by that - what does the vet say?

Hi! They are thinking his symptoms are related to the hyperT, but if his GI systems persist even after his numbers level out with the Methimazole, then we have to explore other options regarding the GI issues.
 
Hello neighbour. Sorry that Carter seems to have so much going on. :bighug: My mind went the same place as Tricia's so I am glad to hear that his bowels look good. I assume no lymph node involvement either? I just heard a scary stat from a vet on how many lymphoma cats don't have thickened bowels. But the hyperT sounds like it may be it. You may want to join a thyroid group. I joined https://groups.io/g/FelineThyroidManagement/ for a bit when Neko had low T4. Thought it might have been the SRT but it wasn't. Anyway, very knowledgeable people in that group.
 
Hey Erica, I am so sorry that Carter is having so many issues and I can imagine your head spinning for sure. Before I even finished reading your post where you got to the labs I thought hyper T as it sounded just like my civvie Forrest before he was DX last year. Losing weight, starving hungry, and very very needy, always wanting attention ( apparently that is one of the signs too) . He also would scarf and barf often before I got him on the Methimazole and I just thought it was just that, scarf and barf but apparently, frequent vomiting is another one of the symptoms. Since we started on the Methimazole, that has slowed down appreciably , it might only happen once a month or so.

Forrest's levels before DX was just slightly over normal so it was caught soon and @Marje and Gracie recommended that I do not start him on 1/2 of a 5mg. pill twice a day as most vets with RX but to give him 1/2 of that; I cut the pills into quarters and gave him a 1/4 tab twice a day. Apparently, starting on the higher dose is old school and a lot of kitties are then thrown into Hypothyroidism and then the meds have to be stopped for a while till levels level out. I followed her suggestion and when I took him back in 3 weeks to test his levels , I told the vet that I had only given him 1/4 pill twice a day and his levels were just perfect! So that is still his dose.

After Carter starts on the methimazole , perhaps you won't even have to consider given the SEB at all especially since there is no diarrhea. Maybe a better idea would to give a digestive enzymes and probiotic daily instead. My civvie gained back his weight shortly after he got stable on the methimazole so, I hope that will happen for Carter as well as it sounds you are very concerned with his thinness.

@Marje and Gracie is the one here who is a wizard with labs interpretation so hopefully she will be able to help you. I don't know if the meth impacts BGs or not. It is a common thing for FD's to have Hyper T as well.

It is good to hear from you despite the issues at hand and glad your move there has been a good one for you.
Hi Bobbie,

Thank you for the input! I was old told in the hyperT Facebook group too to start at 1.25mg twice a day instead of what most will recommend starting at 2.5mg or even 5mg twice a day. I will mention this on Friday when we are discussing dosing. Since he is in the grey area, I don't see why a lower (or the lowest) dose wouldn't be appropriate to start out on.

That's good to hear your Civvie bounced back from this. I feel like a bad mom for not putting 2 and 2 together sooner but he's always been super food motivated and needy, and weight wise we had been trying to keep his weight down due to his prior obesity, but now it's kind of like "derp!" why didn't I assume this sooner, instead of treating everything as a separate issue.
 
Hi Erica.

It's great to hear from you, and I'm happy that Carter's FD is still in remission, but I'm sorry about all the other issues. I don't really have any input for you, except to offer you vines and prayers for answers and improvement. Knowing that it's NOT IBD or intestinal lymphoma is certainly good news, as that was the first thing I thought when I started reading.

I was going to tag Marje, but I see someone beat me to it. If anyone here can give you good feedback, it's Marje.

Congrats on the new job. Sounds ideal, given Carter's issues.

Please keep us posted!
Thank you Tricia! I was happy to hear it wasn't IBD as well, but still I'm worried about his poor little liver. I guess one step at a time.
 
Minka and Harvey both were Hyper T. Harvey was asymptomatic, but Minka was hyperactive, hungry all the time and losing weight. She was on Felimazole for years. she did have a tumor removed, along with part of her thyroid, but after about six months her numbers went up again and she went back on the Felimazole for the remainder of her life. I know some say their cats have side effects from it, but Minka never did.
 
why didn't I assume this sooner, instead of treating everything as a separate issue.
Cut yourself some slack. You've had a lot going on. I remember thinking the same thing about Forrest "how did I not notice the weight loss?" When we see them every day things aren't always so apparent.

I too, think it's wonderful that IBD and lymphoma was ruled out. Hyper T is a very manageable disease. My civvie, Sug, got DX when she was 12 and she lived to be 17 1/4 years old. :cat:
 
Hello neighbour. Sorry that Carter seems to have so much going on. :bighug: My mind went the same place as Tricia's so I am glad to hear that his bowels look good. I assume no lymph node involvement either? I just heard a scary stat from a vet on how many lymphoma cats don't have thickened bowels. But the hyperT sounds like it may be it. You may want to join a thyroid group. I joined https://groups.io/g/FelineThyroidManagement/ for a bit when Neko had low T4. Thought it might have been the SRT but it wasn't. Anyway, very knowledgeable people in that group.

Thank you Wendy! I'll have to take a look at the report again, but I believe it might have mentioned nothing abnormal regarding the lymph nodes. I'll definitely be checking that group out, good to know there is a hyperT equivalent to FDMB. :P
 
Minka and Harvey both were Hyper T. Harvey was asymptomatic, but Minka was hyperactive, hungry all the time and losing weight. She was on Felimazole for years. she did have a tumor removed, along with part of her thyroid, but after about six months her numbers went up again and she went back on the Felimazole for the remainder of her life. I know some say their cats have side effects from it, but Minka never did.
I'm wondering if Carter is presenting as symptomatic if that would be an option for him?
 
Cut yourself some slack. You've had a lot going on. I remember thinking the same thing about Forrest "how did I not notice the weight loss?" When we see them every day things aren't always so apparent.

I too, think it's wonderful that IBD and lymphoma was ruled out. Hyper T is a very manageable disease. My civvie, Sug, got DX when she was 12 and she lived to be 17 1/4 years old. :cat:
Good to hear! The hyperT seems managable, I think we just need to get our foot in the door. I'm hoping we don't have to get a biopsy of the liver, that does scare me.
 
Don't beat yourself up for not knowing sooner. You're doing the best you can for Carter and you are getting him help now. I don't have any advice to offer, but am sending prayers. :bighug::bighug::bighug:
 
Does anyone know if I should up his food intake? or will it no matter until his thyroid is normalized?

Good question. With my civvie, I gave him more calories until he was stable ( actually, he is still eating like a horse but gained back his weight loss) but, he is not diabetic so I really don't know the answer to your question. Maybe some others with both diseases will weigh in.
 
My answer is the same as Bobbie's Minka was not diabetic, and I let her eat as much as she wanted. She did get close to her normal weight once we had her on the meds. Harvey didn't lose weight due to his Hyper-T, and didn't have the increased appetite, so I didn't feed him any more.
 
Hi Erica. Were you posting in the Hyperthyroid Cats facebook group?
My kitty Ginger was pretty much asymptomatic with her hyperthyroid, except she threw up a lot (hairballs, scarf & barf, acidy tummy, and sometimes eating grass to throw if up). The vets always said she just had a sensitive tummy. Her T4 started slowly rising and even though she kept her weight and acted pretty normal, we just had the i131 done. Anti-jinx *** she has not thrown up since *** Anti-jinx. She is still her active self and still eats her normal food hungrily. If you are the same person who was posting on facebook, I was hoping that working for the vet that you would be able to make payments for the i131 treatment.
I always gave probiotics about 2 hours after giving antibiotics. The antibiotics kill both bad and good bacteria and the probiotics put the good bacteria back in the gut.
 
Hi. I also have a cat who was hyperT for a few years. His T4 went up before he had a few resorptive lesions (FORLs) removed then went back down before creeping up for 3 years. He had only 1 symptom and that was vomiting. I had i131 done 3 years ago. He did become hypOt, but at least the tumor is gone! He gained all his muscle back on his spine and hips. He's doing great and he just turned 17 years old.
I’m glad someone recommended that group because Ro is awesome and can read labs.
It will all work out! :bighug:
 
Hi Erica. Were you posting in the Hyperthyroid Cats facebook group?
My kitty Ginger was pretty much asymptomatic with her hyperthyroid, except she threw up a lot (hairballs, scarf & barf, acidy tummy, and sometimes eating grass to throw if up). The vets always said she just had a sensitive tummy. Her T4 started slowly rising and even though she kept her weight and acted pretty normal, we just had the i131 done. Anti-jinx *** she has not thrown up since *** Anti-jinx. She is still her active self and still eats her normal food hungrily. If you are the same person who was posting on facebook, I was hoping that working for the vet that you would be able to make payments for the i131 treatment.
I always gave probiotics about 2 hours after giving antibiotics. The antibiotics kill both bad and good bacteria and the probiotics put the good bacteria back in the gut.

Hey! Yes that was probably me, I'm in so many pet related groups/forums it's hard to keep track. :P

Unfortunately my practice doesn't offer the i131 treatment, or otherwise I'd get a discount. Some practices offer a "professional" discount for employees that work in the field, but I'd have to see.

I think re: probiotics I might just go with giving only S.Bouraldii for a while with the antibiotics. With my schedule it's hard to space things apart.
 
Hi. I also have a cat who was hyperT for a few years. His T4 went up before he had a few resorptive lesions (FORLs) removed then went back down before creeping up for 3 years. He had only 1 symptom and that was vomiting. I had i131 done 3 years ago. He did become hypOt, but at least the tumor is gone! He gained all his muscle back on his spine and hips. He's doing great and he just turned 17 years old.
I’m glad someone recommended that group because Ro is awesome and can read labs.
It will all work out! :bighug:

That's awesome to hear how he improved! I'm sure I'll definitely be active in that group. I know I work in the veterinary field but I trust this forum more than most veternarians, which I'll never admit at work because l do love my job, but I also know people who live and breathe these diseases every day essentially become specialists and have a vast amount of knowledge.
 
Also I talked it over with my spouse and I think we are going to keep him on the Bravo canned, and maybe try the Koha Roo formula as well. He is doing well on it, and I don't think it's the food itself that is contributing to the vomiting at all but I always second guess myself. I'd love to go back to EZ Complete but I live in a small apartment now, work 12 hour shifts, and just don't have the space at this time.
 
Glad to hear you're settled in now after your move, and your new job sounds wonderful! Sorry that Carter has had such a rough time of it, but don't beat yourself up about it. Sometimes it's hard to see stuff that's right under our noses because it's so gradual that we don't really notice right away.

I can't help with advice for the hyperT but you mentioned trying s.boulardii, and that I can help with. I have a civvie who stays on a maintenance dose of s.boulardii. She gets 1/2 capsule twice a day with meals as her maintenance dose, and a full capsule twice daily if she has a flare. She has IBD and it has really helped her. I use the Now brand, from amazon.com.
 
Glad to hear you're settled in now after your move, and your new job sounds wonderful! Sorry that Carter has had such a rough time of it, but don't beat yourself up about it. Sometimes it's hard to see stuff that's right under our noses because it's so gradual that we don't really notice right away.

I can't help with advice for the hyperT but you mentioned trying s.boulardii, and that I can help with. I have a civvie who stays on a maintenance dose of s.boulardii. She gets 1/2 capsule twice a day with meals as her maintenance dose, and a full capsule twice daily if she has a flare. She has IBD and it has really helped her. I use the Now brand, from amazon.com.
Thanks Lucy! I just bought that brand for Carter, should arrive this weekend.
 
@Erica & Carter

Sorry to just get here now but I’ve had a lot of company lately.

I’m sorry to hear Carter is having so many issues. I’ve had cats with hyperT and liver issues so I’ll just throw some thoughts out there. First, I don’t agree that the probiotics and antibiotics cancel each other. I think you should definitely separate them in time but the probiotics will help keep a healthy flora of bacteria that the antibiotics might impact. Have you asked Laurie or Carolina in the FB Raw Feeding for IBD group? I know his U/S indicates he doesn’t have IBD but those ladies are pretty smart when it comes to probiotics. I’d just double check there if you haven’t but probiotics are a staple around our house in the humans and cats and my vet is definitely on board with the cats having them especially when they are on antibiotics. I also use a very small maintenance dose of S. boulardi with Tobey as he had giardia as a baby and the more support I can give his intestines, the less the likelihood of him getting IBD.

Are you familiar with Dr. Jean Dodds at Hemopet. I’ve always used her for diagnosing thyroid issues. Your vet can do the blood draw and you can mail the sample to her (of course, before you start treatment) and she’s pretty fast with results. All the instructions are on her site. They also send along their interpretation. They do not use equilibrium dialysis and I think their methods are probably pretty cutting edge for diagnosing hyperT. I had a little kitty with all the symptoms but the usual tests through Antech weren’t showing she was hyperT and when Dr. Dodds ran the feline thyroid profile, she was definitely hyperT. I also think the recommendation to start low with the methimazole (MMI) is smart. I can’t remember the last time I heard of a cat started at the 2.5 mg bid that didn’t have an issue with it. I’m sure there are some but it can certainly cause side effects. The other issue with MMI is it can also cause liver issues. It’s not a drug I am fond of and, personally, I think the sooner you can get the I131 done, the better. I’m not sure it’s a good idea for the hyperT to go untreated while you wait for the liver to calm down nor do I think it’s good to wait to treat it until you can afford I131 unless you are talking two weeks (because you have to stop MMI for about two weeks, I believe, before the I131). The reason you want to treat the hyperT as soon as you can, one way or the other, is because, untreated, it can cause a host of other issues including liver issues, heart issues, etc. Untreated, and even treated but uncontrolled, hyperT can result in a thyroid storm and that is a very bad thing. Because his liver values are so high, the potential for this really concerns me. Mild elevations in ALT would be up to about 300 or so and he’s way above that.

You can up his food intake but until the thyroid is treated, but he’s going to burn right through those calories. If there is any way at all you can swing it, I’d first get a solid diagnosis and then I’d get the I131.

Sending vines for him. Please let me know if you have questions. And BTW...I usually like to look at the complete panel of labs because it’s just smart to look at values in conjunction with each other.
 
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