That's true, but with a depot that large, I think it would take a while to drain. This is just my opinion, and I am by no means a high dose expert. Perhaps @Wendy&Neko will have other thoughts.
I wouldn't call that much of a depot draining dose. I strongly suspect last night's 10u dose was still being influenced by the 11.5u previous doses. Going from 11.5u down to 10u is only a 13% reduction which isn't a big reduction. I do 25-33% one time reductions to drain the depot a bit, and some do closer to 50%. I would consider sticking with the 10u for a few cycles and see how she does. Of course, until the bounce clears, we don't really know where she will end up. As it gets closer to shot time, we can see where her numbers are, but Lev and Lantus crave consistency so I would try to stick with a consistent dose for a few cycles unless she dips low again. How fast does TiTi usually clear her bounces?
That is what I have been taught from the veteran high-dosers when dealing with a high dose cat. This is where the depot draining bcs becomes a handy tool to help let the depot adjust quicker, especially when the kitty decides to take a few back to back reductions and the bean is tired from multiple late night PJ parties.
If you take a reduction, then the next 6 cycles can be influenced by the depot of the larger dose you had just been giving. And especially in the first few cycles, the depot may have a strong influence.
The bounce made her numbers go higher. If she hadn't bounced she would have started with lower numbers and been more likely to go lower. Maybe not the 20's since it's been a couple cycles since you shot the larger dose, but possible still below 50.
Bounces are a totally confusing topic.Here's what I didn't understand about bouncing. I thought there'd only be 1 bounce - all the way up, and then all the way down, and then back to normal. Dunno why I visualized that, since most bounces (ping pong balls etc) bounce thru' quite a few ups and downs.
They go up, they go down, they swing around. A ping pong ball is a good comparison.
If you take a reduction, then the next 6 cycles can be influenced by the depot of the larger dose you had just been giving. And especially in the first few cycles, the depot may have a strong influence.
The bounce made her numbers go higher. If she hadn't bounced she would have started with lower numbers and been more likely to go lower. Maybe not the 20's since it's been a couple cycles since you shot the larger dose, but possible still below 50.
Bounces are a totally confusing topic.
BTW, it's really your choice if you want to go to 10.5 or stick with 10 units tonight. Every change in dose makes it harder to figure out what size the depot thinks it is, so staying with 10 units does have it's advantages cause you've been shooting it for two cycles now. I just thought it might be too low a dose. Your call.
If Titi has acromegaly, which we suspect, then you don't need to worry about healing numbers. There's a good chance her pancreas is already working. It's the growth hormone and subsequent IGF-1 that is blocking the cells and preventing her native insulin from getting in, hence the need for injected insulin. What you do want to do is keep her mostly in numbers below renal threshold, which varies by cat but is somewhere high blues/low yellows. High numbers make her kidneys work harder, but they shouldn't be a concern for the other organs.
