Penny-End Stage Renal Failure DX-HELP!!

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She's peeing up a storm so hopefully SOMETHING is getting cleaned out!
It will be - Rosa could pee for the Olympics a few hours after she gets fluids...and she's only on a tiny maintenance amount just yet. She's not dehydrated either - we just use the fluids to try and stop her creatinine rising any further. I usually just do a quick check the next morning to make sure she doesn't feel too 'squishy' anywhere, though Rosa also has a belly even though she's not overweight...her stomach muscles were damaged when she had the bladder stones surgery and never really got all the way back in shape.
 
I have to get to sleep but THANK YOU ALL for making me feel SO much better about all of this! First, seeing so many cats living several quality years after diagnosis. Penny is only 7 and i just lost her civvie sis Weeny at the young age of 4 last September to a rare (in cats) malignant mast cell cancer so I just can't lose Penny yet. Especially Penny. Y'all told me when she was first dx'ed with diabetes that this would make us closer and more bonded and y'all were SO right about that! And thank you for giving me hope that home sub cu's CAN work to get her down and the tips on howwhere to get the stuff the cheapest b/c I def don't wanna pay for the vet's markups for too long lol. Here's to hoping she starts eating solid food soon because she's costing us a fortune blowing through 8 Weruva Cats in the Kitchen pouches per day. Plus I want her back on her low carb food! Although...Weruva doesn't spike her very much even though they are high carb. Isn't that weird?

anyway...I'm rambling. Thank you guys SO Much! For the first time since her diagnosis I feel hopeful! <3
 
To the best of my knowledge, the danger of aluminum toxicity has only occurred in humans who are also on dialysis. I don't think there's any precedent of it showing up in cats - maybe because they have a shorter lifespan, or maybe because they don't have it build in their system the same. Used as a binder in the correct quantity, it's safe. That said, I've never dosed anywhere near as high as 100 mg per lb - the maximum dose I've used is 200 mg per day for a 10lb cat which actually falls right in the middle of the IRIS recommended dosing on Tanya's site at 20 mg per lb (we started at the lower end of the dosing scale, worked up it gradually and found Rosa's levels were fine by the time we got to 20 mg per lb). Personally, the dosing method I prefer is to use the minimum possible of anything like ALOH, just in case.

That dosing is Dr. Nagode's protocol. High impact quickly to reduce quickly
 
The problem is, I'm giving them in her flank. And it's settling into her belly. which is big to begin with lol. I guess I just have to feel how squishy it is in the morning.

If possible can you give half a dose twice a day? Might be easier and I would also try the scruff.
 
I forget who here gives Adequan and. b12 injections but here's my question. I usually shoot insulin AM meal and then Adequan or B12 (when she's due) at 10am with a meal. I can only shoot while she's eating. I've been doing her fluids just before 10am meal so I'm afraid Rhe b12 and adequan will get diluted and not be as effective. How should I time her other injections around her daily fluids? She's die for b12 today and adequan this Monday
 
I forget who here gives Adequan and. b12 injections but here's my question. I usually shoot insulin AM meal and then Adequan or B12 (when she's due) at 10am with a meal. I can only shoot while she's eating. I've been doing her fluids just before 10am meal so I'm afraid Rhe b12 and adequan will get diluted and not be as effective. How should I time her other injections around her daily fluids? She's die for b12 today and adequan this Monday
I give adequan a few hours after ( have done as early as 1 hours after... maybe feed her a little less and then again in a hour or 2 or so?)--for us I have not seen it change the effectiveness -- we do 1x a week as my guys are seniors :)-- i
I dont do the b12 I am sure someone will have a answer for you:cat:
 
I could try her 4pm meal or 11pm test snack. She's been doing great with just the once every four weeks after the loading period with adequan so I don't wanna mess that up for her. The great news is that her weight is holding steady so far. She could lose another lb or two but I don't want her to lose it THIS way lol. I'll try 11pm which will be about 12hrs after fluids.
 
With Autumn I did insulin at her 7 am meal, fluids with her snack at 1 pm, insulin again at 7 and adequan at her 10 pm before bed snack, when needed.

Mel and The Fur Gang
 
I put Rosa's B-12 shot in the port on the line right before we give fluids - our vet told us it doesn't matter if that one absorbs more slowly along with the fluids. When we were giving Shadow Adequan, we were told NOT to do that with the Adequan but instead to give Adequan first and wait a couple of hours minimum before giving the fluids.
 
I did B12 when I did the fluids, the vet told me I could put it right into the line as the sub-q fluids are running.... just inject into one of the little ports.

Adequan, I did at a different time, when the sub-q fluids were not being done or had already absorbed.
 
Hi Robyn! I watched your video of Penny (for those with access on Facebook, here is the link: https://www.facebook.com/robynhw/vi...5828802500630/?type=2&theater&notif_t=mention). She looks good! Bright eyed, etc.

You had asked earlier about the needle gauge when giving subQ fluids. 18g I believe is the standard that a vet's office gives you with a bag of fluids, and it *is* a kitty harpoon. I always used Terumo ultra-thin wall (UTW) 21g needles. I ordered them, along with Lactated Ringers Solution a case at a time from Thriving Pets. Depending on your state, you will likely need a veterinary prescription for the fluids. But just for comparison's sake, My vet was charging me like $28 for a bag of fluids, an IV admin set (the tube that you spike into the fluids and put the needle on the other end), and 10 needles. Ordering them in bulk from Thriving Pets - 12 bags of fluids, 12 IV admin sets, and 100 Terumo UTW 21g needles brought that cost down to about $6.50 for the same stuff. But back to the needles - the higher the gauge, the smaller the hole in the needle, the slower the fluids go. So it's a trade-off. If she'll sit still while getting fluids, you can go with the more slender needle. Another trick we always used was to keep the needles themselves in the freezer, which seemed to lessen the pinch when inserting it. We also warmed our fluids. Because I was afraid to overheat them in the microwave, I would always just use a big spaghetti pot of hot water, and I would put the fluid bag in that pot of hot tap water (with the end where the spike from the tube that goes into the bag UP and not in the water itself) and leave it for about 5-10 minutes so that it was warmed to roomish-temperature. I would then "bleed" the line - let the colder fluids in the line drain out onto my wrist - to ensure the temperature wasn't too hot or too cold. So that's one thing.

Another thing I'm still stuck on with your Penny is how fast her kidney values ascended since totally normal bloodwork in June of 2015. *Chronic* kidney insufficiency generally onsets slowly. Of course, every cat is different - but going from "I'm normal" to "My creatinine is 11" in an 8 month period just seems more of an acute onset logically speaking, especially given her overall body condition and the demeanor you describe prior to the dental/eating crisis. An acute onset can be caused by a lot of things - infection, sudden serious dehydration, ingesting any kind of an NSAID (ibuprofen, naproxyn sodium etc.), and even ingesting lilies, which are also nephro-toxic. Let me ask: was penny at ANY point on Metacam (meloxicam) oral for either her teeth or her arthritis? Metacam is an NSAID - and it has been known to drive cats into acute onset kidney failure with greater frequency than I think most people are aware.

So, I really, really want you to have a conversation with your vet about acute vs. chronic, and even acute episode over milder chronic kidney insufficiency. The treatment routes are essentially the same, but you'll want to be rechecking bloodwork a lot more frequently than you might otherwise (every two weeks initially) and adjust treatments, particularly subQ fluids, if her kidney values come down. Another reply in this thread referenced needing to post ALL of the bloodwork to the CRF group - I concur with that. It's helpful to see Penny's creatinine, phosphorus and BUN, but there are a whole bunch of other values that kidney cat parents want to see to gauge overall condition. Calcium, ALT, ALP, RBG, HCT or PCV, potassium, TP - all of that is informative even if within normal range when taken into the big picture consideration. So, if you've joined the CRF group, get a hard copy of Penny's FULL laborwork results and provide them to the CRF list with normal ranges included for reference (because lab reference ranges can vary). Be sure you post all results, not just those outside of normal range. For as long as you are managing kidney issues, you'll want to do this.

Finally - how much is she eating today compared to "normal"?
 
Hi Robyn! I watched your video of Penny (for those with access on Facebook, here is the link: https://www.facebook.com/robynhw/vi...5828802500630/?type=2&theater&notif_t=mention). She looks good! Bright eyed, etc.

You had asked earlier about the needle gauge when giving subQ fluids. 18g I believe is the standard that a vet's office gives you with a bag of fluids, and it *is* a kitty harpoon. I always used Terumo ultra-thin wall (UTW) 21g needles. I ordered them, along with Lactated Ringers Solution a case at a time from Thriving Pets. Depending on your state, you will likely need a veterinary prescription for the fluids. But just for comparison's sake, My vet was charging me like $28 for a bag of fluids, an IV admin set (the tube that you spike into the fluids and put the needle on the other end), and 10 needles. Ordering them in bulk from Thriving Pets - 12 bags of fluids, 12 IV admin sets, and 100 Terumo UTW 21g needles brought that cost down to about $6.50 for the same stuff. But back to the needles - the higher the gauge, the smaller the hole in the needle, the slower the fluids go. So it's a trade-off. If she'll sit still while getting fluids, you can go with the more slender needle. Another trick we always used was to keep the needles themselves in the freezer, which seemed to lessen the pinch when inserting it. We also warmed our fluids. Because I was afraid to overheat them in the microwave, I would always just use a big spaghetti pot of hot water, and I would put the fluid bag in that pot of hot tap water (with the end where the spike from the tube that goes into the bag UP and not in the water itself) and leave it for about 5-10 minutes so that it was warmed to roomish-temperature. I would then "bleed" the line - let the colder fluids in the line drain out onto my wrist - to ensure the temperature wasn't too hot or too cold. So that's one thing.

Another thing I'm still stuck on with your Penny is how fast her kidney values ascended since totally normal bloodwork in June of 2015. *Chronic* kidney insufficiency generally onsets slowly. Of course, every cat is different - but going from "I'm normal" to "My creatinine is 11" in an 8 month period just seems more of an acute onset logically speaking, especially given her overall body condition and the demeanor you describe prior to the dental/eating crisis. An acute onset can be caused by a lot of things - infection, sudden serious dehydration, ingesting any kind of an NSAID (ibuprofen, naproxyn sodium etc.), and even ingesting lilies, which are also nephro-toxic. Let me ask: was penny at ANY point on Metacam (meloxicam) oral for either her teeth or her arthritis? Metacam is an NSAID - and it has been known to drive cats into acute onset kidney failure with greater frequency than I think most people are aware.

So, I really, really want you to have a conversation with your vet about acute vs. chronic, and even acute episode over milder chronic kidney insufficiency. The treatment routes are essentially the same, but you'll want to be rechecking bloodwork a lot more frequently than you might otherwise (every two weeks initially) and adjust treatments, particularly subQ fluids, if her kidney values come down. Another reply in this thread referenced needing to post ALL of the bloodwork to the CRF group - I concur with that. It's helpful to see Penny's creatinine, phosphorus and BUN, but there are a whole bunch of other values that kidney cat parents want to see to gauge overall condition. Calcium, ALT, ALP, RBG, HCT or PCV, potassium, TP - all of that is informative even if within normal range when taken into the big picture consideration. So, if you've joined the CRF group, get a hard copy of Penny's FULL laborwork results and provide them to the CRF list with normal ranges included for reference (because lab reference ranges can vary). Be sure you post all results, not just those outside of normal range. For as long as you are managing kidney issues, you'll want to do this.

Finally - how much is she eating today compared to "normal"?

I'm gonna go with the Terumo 19g thin wall b/c she doesn't sit still well and Mom is the one who holds her down while I'm giving the fluids. I freeze the needle a couple of hours before hand and have been warming the fluids. As far as I know, she was never on Metacam but she was 3 1/2 when I adopted her so not sure what they used for her spay. We don't keep lillies in the house and she's an indoor only cat and no chance she would have gotten into any ibuprofen, but vet #2 did hint that dentals have a way of "fixing a lot of things" and also said that kidney infections don't always show up in free catch urinalysis and no vet has ever been successful in cystocentesis or whatever that's called lol. I posted her blood results on the CKD FB page but I can always send them to you on FB. Can I post them here? I'll try after I type this reply lol. I asked Vet #1 about the possibility of acute vs chronic and he said it is possible but can't promise anything. We are rechecking her blood/chem in about a week and a half, which will be two weeeks after her dental because we do want to see if she still needs so much fluid, etc.

As for her eating, she's def eating less. She can't eat her kibble (she's on Young Again Mature Health now) and not really eating the FOOD in her wet meals, but is blowing through 5-6 packets of weruva gravy (which is killing me b/c it's high carb lol) per day as well as some juice from the lower carb Weruva cans. Mom is picking up the Nutro Natural (I never thought I'd see myself feeding nutro but this cat is hungry and we need low carb food that will stick to her ribs) soft loaf food b/c I did realize last night she CAN at smooth pate food, although she's still spilling alot on her chest. Her weight is holding steady around 15 1/2lbs right now. I weigh her every morning before fluids to make sure she's passing what I'm giving her. Gonna try to upload her blood work results here now but I have it in JPEG format so not sure I can do it lol
 
Penny bloodwork 1 Feb2016.jpg
Penny bloodwork 1 Feb2016.jpg
Penny bloodwork2 Feb2016.jpg
Penny bloodwork2 Feb2016.jpg
 
Those lab values show severe kidney insufficiency. You need to get the phosphorous level down since that make a cat feel bad and can lead to inappetence.
 
Those lab values show severe kidney insufficiency. You need to get the phosphorous level down since that make a cat feel bad and can lead to inappetence.

Those values ARE high, and the phosphorus is a concern. As I said in an earlier post from Friday, high phosphorus is a double-threat of bad for any cat with acute or chronic kidney issues. It makes them feel crappy - not in pain, but just crappy - and generally makes them inappetant. But on top of that, high phosphorus definitely speeds degradation in kidney function. So on both of those points, that has to be addressed. Have you commenced using the binder? If so, which kind, how much and how often? Another poster had recommended you split the daily dose into however many meals Penny has, and that's good advice. So let's say you go with 1500mg daily, and Penny eats 3 meals. You would give her 500mg with breakfast, 500mg with lunch, and 500mg. with dinner. I definitely think that phosphorus is a priority for you to address.

As far as only licking the gravy off of Weruva, that says a few possibilities to me. First, her mouth just may be hurting and all you can do is attend that post-dental and administer pain medications as indicated. A second possibility is either an excess of stomach acid (common in kidney cats) and/or generalized nausea. These are two different things treated differently. For excess stomach acid, you can go with a simple famoditine dose. Brand name is Pepcid AC (NOT Pepcid Complete or Pepcid Maximum Strength - original strength!). Pepcid AC is 10mg famotidine, and you would administer 1/4 of that 10mg tablet (i.e., 2.5mg) daily to start and see how she does. For nausea, having either Cerenia or ondansetron on board would be helpful. Then you've covered all those bases. Does she often sniff food, show interest, but then just not eat? Does she sniff food and lick her lips but then generally not eat? Do you see her licking her lips just generally? All of these are signs of stomach upset either from acid or nausea. So be aware of that.

Eating a proper amount is always a first priority with a cat with any illness, chronic or acute. You know how cats are physiologically speaking, and they evolved to eat many small meals throughout the day. If she's not eating as much as history told she should normally, then you have to be on high alert and figure out exactly how much less she's eating, and then do what you can to get that up. With proper treatment of nausea/acid, you can also try an appetite stimulant. I believe you had mentioned that she was taking mirtazipine - not my favorite appetite stimulant, and if she's not eating enough it's not working. Since it's a 72-hour drug, ask the vet if you can switch to cyproheptadine - 1/4 of a 4mg tablet (despite the fact that the vet will tell you 1/2 - start low) when the current 72 hours of mirtazipine is up. I think it's safer, and it's dose-to-effect; meaning, you can give it daily and sometimes twice a day until you see the effect you want. As with all appetite stimulants, it may cause restlessness and vocalization. My beef against mirtazipine is that, although adverse reaction is rare, adverse reactions are severe, and my Grady had one to mirtazipine. It made him have to go into the ER, and the antidote the animal poison control center recommended was cyproheptadine, so I don't use mirtazipine with my cats any longer. Symptoms of adverse reaction in Grady were excessive drooling, weakness, but coupled with anxiousness. It was a bad scene. So just FYI.

Finally, it's a bummer about the blood sugar, but right now treating the kidneys and getting those values down into a more acceptable range has to be your priority, and eating has to be a priority for Penny. Continued subQ fluids, a lower phosphorus diet, addition of a binder are what I see in reading the bloodwork.

Oh and - yes, kidney infections are notoriously difficult to diagnose. You can have a low level one that doesn't show on even a sterile urine culture (let alone free-catch) that isn't serious enough to elevate white blood cell count on serum bloodwork yet still elevates kidney values in a kidney compromised cat. Is she on an antibiotic besides clindamycin??
 
just want to add that for us cerenia works well for vomiting and ord. for nausea... if she has both I would suggest cerenia first then 15 or so minutes later ord. (if injection) i
if cerenia oral maybe 30 minutes>>>> then ord. who wants to eat when you want to puke :confused:
Many here use pepcid daily-
:cat::cat::cat:
 
Thanks so much everybody! I totally forgot to post an update. Penny started eating almost normally again two weeks ago. I tried using the aluminum hydroxide binder and after two days she wouldn't eat wet food unless it didn't have the binder in it. So I stopped for a few days because first priority is her EATING. She's on primarily Weruva flavors that are low carb with phos under 90% if I can help it, And Young Again Zero Mature, which is .50%phos dry matter. I did start Epakitin last week two days before her blood work knowing that it probably wouldn't have made a dent in her number that quickly. My vet is ordering ConSeal but someone in the office dropped the ball and they didn't order till yesterday.

That all being said, her blood work last Wed showed dramatic improvement. BUN is 66, down from 138. Creatinine is 3.2, down from 11. Phosphorus was 5.2, down from 12.8, which is incredible considering I've been so unsuccessful with this binder lol. And even her BG on the chem panel, after being completely ticked off by the vet b/c she's a "hard stick" and hard to get blood from, was 112 on .75u of Lev that morning.

The vet has me still doing 150ml lactated ringers daily, since I CAN lol, and phos binder/Pepcid as needed. I just started Pepcid this morning b/c she puked up about 2 tbls foam and despite all the fluids, has been drinking a boatload of water the past few days.

Two questions...does her sudden need for Pepcid potentially mean her numbers are gettign worse? And for those using ConSeal, does it raise BGs? Amazingly, the Epakitin, despite lactose being hte first ingredient, has not!
 
Thanks so much everybody! I totally forgot to post an update. Penny started eating almost normally again two weeks ago. I tried using the aluminum hydroxide binder and after two days she wouldn't eat wet food unless it didn't have the binder in it. So I stopped for a few days because first priority is her EATING. She's on primarily Weruva flavors that are low carb with phos under 90% if I can help it, And Young Again Zero Mature, which is .50%phos dry matter. I did start Epakitin last week two days before her blood work knowing that it probably wouldn't have made a dent in her number that quickly. My vet is ordering ConSeal but someone in the office dropped the ball and they didn't order till yesterday.

That all being said, her blood work last Wed showed dramatic improvement. BUN is 66, down from 138. Creatinine is 3.2, down from 11. Phosphorus was 5.2, down from 12.8, which is incredible considering I've been so unsuccessful with this binder lol. And even her BG on the chem panel, after being completely ticked off by the vet b/c she's a "hard stick" and hard to get blood from, was 112 on .75u of Lev that morning.

The vet has me still doing 150ml lactated ringers daily, since I CAN lol, and phos binder/Pepcid as needed. I just started Pepcid this morning b/c she puked up about 2 tbls foam and despite all the fluids, has been drinking a boatload of water the past few days.

Two questions...does her sudden need for Pepcid potentially mean her numbers are gettign worse? And for those using ConSeal, does it raise BGs? Amazingly, the Epakitin, despite lactose being hte first ingredient, has not!
So happy she is doing better.
I am sure others will have input about the Pepcid. I personally think it is just the renal issue. The acidity that comes with the disease. We just started using it with Rico and it does help. I put it in a capsule because it has a bitter taste and only use as needed 2.5 mg.
I think the fluids are your best friend right now :)
 
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