Hi Sherri
First here are some



. That was a tough night.
Thank you for all the valuable information. It's good news that you managed to give Shamus some insulin and get some fluids into him: both things are extra important in kitties who are ketone-prone. The insulin will help him to properly use what nutrients he's getting, and the fluids will help to flush out any ketones present.
I'm very glad that you managed to speak to the out of hours vet service, and I think it's a good plan for you to bring Shamus in to see the vet today to get him checked over. Food, insulin and fluids are key to combatting ketones. In particular see if they can do a test of
blood ketone levels.
I think it might be a wise plan to get a supply of the food that Shamus was able to eat OK while he was staying at the vets. The Hills w/d canned may not be the greatest carb-wise, but if he can eat it successfully right now, then right now that's the 'right' food to help get Shamus stabilized. (His insulin can be worked around it.) Also, there is another anti-nausea medication used to help inappetent cats called ondansetron. Some cats do better on ondansetron* than Cerenia. (Apparently the latter may help more when vomiting is a symptom.) I'd suggest asking the vet for this med. If he doesn't have it in stock today, maybe he could issue a written Rx for it. Ondansetron is a human medicine and you should be able to get it at a regular pharmacy. Typical dosage is 1mg twice a day (although our vet has prescribed up to 2mg twice a day for Saoirse, who weights c. 10lb.)
I'd also suggest asking your vet about the Lantus dose.
It is vital that you maintain some level of insulin treatment because Shamus is vulnerable to ketones and is unable to eat properly at the moment. I'd recommend asking your vet for guidance on giving reduced or even token doses of Lantus while you get Shamus' eating stabilized. According to the research done by Dr Jacqui Rand of University of Queensland, starting doses of Lantus in cats who have not received insulin before are usually based on the cat's weight, at a rate of 0.25 units per kilogramme. According to those guidelines Shamus, at 14lbs (c. 6.4kg), would rate a starting dose of 1.5 units of Lantus BID (twice a day). Your vet may have tweaked Shamus' dose up to 2.0 IU BID based on readings they took during his hospital stay, but it is a little on the high side for a starting dose so maybe there's a bit of wiggle room to give a lower dose for the time being.
The cyproheptadine dose may be a little on the high side**: 1/8 of a 4mg tablet every 8-12 hours is a typical dose, but again your vet may have reasons for prescribing a higher dose. Certainly it sounds like it's stimulating Shamus' appetite well (he was interested in food last night) but the behaviours you describe sound very much like
nausea symptoms. you need to get the nausea under control or it could set up food aversions later (cat feels compelled to eat even when it feels sick after eating and therefore starts to hate the food). It might be worth asking your vet whether it might be beneficial to give Shamus a stomach acid blocker like famotidine or ranitidine in addition to his anti-nausea med and appy stimulant.
I
strongly recommend that you start testing Shamus' blood glucose at home without further delay. It will give you real time feedback on how safe it is to give Shamus insulin. When you're out and about shopping for urine test strips I suggest picking up a supply of test strips for your new glucometer. We can help you learn how to home test.
How are things with the two of you at the moment, Sherri?
Mogs
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* Check prices - Zofran is the branded version of ondansetron and it's crazy expensive over here. I use a generic for Saoirse. It works very well and is 1/10th the price. Make sure you don't get the Zofran melts preparation - you can't split them and they contain artificial sweeteners. (I found that out the expensive way.

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EDITED TO ADD:
** If the dose of cyproheptadine is too high for an individual cat, it can cause excessive sedation and possibly somewhat depressed mood.