Larry and Kitties
Member Since 2009
The paper compares treatment of DKA with subQ glargine against other methods.
https://onlinelibrary.wiley.com/doi/full/10.1111/vec.13062
(In conclusion, although the study was underpowered to detect differences in time until resolution of ketonemia, the results suggest that the basal-bolus administration of insulin glargine is a useful alternative to the current standard CRI {constant rate infusion}-protocol for the management of DKA in cats. It is simple and associated with a shorter time to first improvement of hyperglycemia and decreased hospitalization time. Additionally, β-OHB measurements using hand-held ketone meters are a useful adjunct for monitoring response to therapy and eliminate the need for frequent blood gas analyses. Further studies are required to evaluate the benefits and disadvantages of IM bolus vs CRI protocols and to compare choices of fluid therapy in management of feline DKA."
https://onlinelibrary.wiley.com/doi/full/10.1111/vec.13062
(In conclusion, although the study was underpowered to detect differences in time until resolution of ketonemia, the results suggest that the basal-bolus administration of insulin glargine is a useful alternative to the current standard CRI {constant rate infusion}-protocol for the management of DKA in cats. It is simple and associated with a shorter time to first improvement of hyperglycemia and decreased hospitalization time. Additionally, β-OHB measurements using hand-held ketone meters are a useful adjunct for monitoring response to therapy and eliminate the need for frequent blood gas analyses. Further studies are required to evaluate the benefits and disadvantages of IM bolus vs CRI protocols and to compare choices of fluid therapy in management of feline DKA."
