Who gave you the green light to increase that much??
Insulin is a hormone and not a drug. A cat needs as much as they need. Freckles is on 11 u right now. That much insulin could be very harmful to another kitty, but Freckles' body needs it and her numbers are showing improvement.
Research supports that many acro cats will need high doses of insulin - all your vet has to do is to research it a bit and it is not uncommon.
1."The insulin requirements of an acromegalic cat will ultimately likely be higher than an average non-acromegalic diabetic. In fact, some acromegalic cats need an extraordinarily high insulin dose and still show a poor response to therapy. A group of 59 acromegalics was found to be treated with an average of 7 IU BID, but with some cats receiving as much as 35 IU BID." Taken from
Acromegaly in Cats
World Small Animal Veterinary Association World Congress Proceedings, 2014
Stijn J.M. Niessen, DVM, PhD, DECVIM, PGCertVetEd, FHEA, MRCVS
2."On average, acromegalic cats require insulin doses more than twice those required in nonacromegalic diabetics, though a small minority will initially have good glycemic control and may even achieve remission. Median insulin doses reported are 7 IU twice a day (range 1–35 IU), though sometimes extreme doses are required that would be fatal in other cats (20 to >70 IU).
32,
92"
Taken from:
Managing feline diabetes: current perspectives - Susan Gottlieb,1,2 Jacquie Rand2
The Cat Clinic, Brisbane, QLD, Australia; 2School of Veterinary Science, The University of Queensland, Gatton, QLD, Australia
3."All developed severe insulin resistance within a few months; peak insulin dosages required to control severe hyperglycemia ranged from 20 to 130 U per day." Taken from: Acromegaly in 14 Cats Mark E. Peterson, DVM, R. Steven Taylor, DVM, Deborah S. Greco, DVM, Richard W. Nelson, DVM, John F. Randolph, DVM, Melissa S. Foodman, DVM, Scott D. Moroff, DVM, Susan A. Morrison, DVM and Clinton D. Lothrop, DVM, PhD. Journal of Veterinary Internal Medicine. Vol. 4 . NO. 4
). Most recent blood test (January 2020) showed slight anemia.
Probiotics can be beneficial for the GI system.
