Pinky's latest VET VISIT to discuss HIGH DOSE

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DEF

Member Since 2011
Pinky went to her new Doc yesterday (2nd visit). I really like this vet. Familar with lantus and home testing. Willing to listen to my concerns.

Last visit we went up to 6u and she asked me to hold it for 2 weeks. Though not TR protocol I was quite happy to do this as I always wanted to know what would happen with a longer trial at a particular dose. Unfortunately, Pinky didn't respond.

I came armed with a copy of Problem Cat article by Rand and an excellent one entitled 'Discovering the Reasons Underlying Difficult to Control Diabetes in Cats' by Cook
.
Each article had a list of tests to consider which I had written down. (Neither by the way mentioned IAA testing, but I asked about this too.)

(I never plan on giving the articles to the vet unless they would ask me for them , which I then would happily do. But I do show them and use it as a back-up of what I am asking for.)

Blood work has already been done to identify hyperthyroidism. (but see the Cook article for more on this and testing free T4). But I ddin’t catch this when reading article prior to appt so didn’t ask about it.

I asked about acromegaly IGF-1 and anti- insulin autoantibodies IAA test.
I know there is also Cushings (though rare in cats) to consider but I didn’t push for that one yesterday—that requires more than bloodwork. I had pancreatitis on my list but forgot completely to ask about it. I believe we discussed ths before but I can't remember with which vet.

She quickly said she would call an internal medicine specialist at lab to ask about the tests. And she did this while I waited which was great.

When she got back she said she actually thought they would say IGF-1 for acro was unnecessary but instead they said it was under-diagnosed and a good idea.

They did tell her that IAA was not a particular useful test for cats and not recommended.

I said I will probably do it anyway for my own peace of mind but I have done a bit more research since then and though I really don’t understand half of what I read I believe they think many cats will test positive anyway as they are on an insulin foreign to their bodies.

Not sure if I have this right or wrong. This is the test that has to be frozen and shipped overnight with ice packs. And you still dose just as you would with regular FD just more aggressively I guess.

I will probably do it but I do think the acro test which does impact treatment decisions is more important but again it might be a relief to see a high IAA number to explain dose.

What was interesting was they said they usually wait to test IGF-1 (acro) until you are at 1 unit per body weight. That would be 10u for me. Given time to think on this I believe I will do it sooner. Because if the cat really is an acro , from what I read, you want to know so you don’t push for below 100 and not be able to bring it back up. Plus there are other treatment options.

Most acro kitties are males but I heard some raspy breathing from Pinky a few times, plus she has GAINED weight, plus the new vet said on first visit she had a big head for a female cat. ???? I completely forgot about acro enlarged extremities when vet and I were laughing about this big head business. But I think her head was always like this, not sure though. Doesn’t look unusual to her parents. (DH and me).

Finally, the big recommendation I got from my vet was not to change insulins but to add another insulin to the equation. I really, really wanted to avoid this but I am coming around to it. I asked her to let me do 6.5 (& maybe even higher) and if that doesn’t work go with her suggestion. I know people on lantus do this all the time. It just seems much more complicated and the ‘gentleness’ of lantus would go out the window.
Lots more testing and more worries so I just wish the lantus would do something on its own.

Elaine and Pinky
 
I think sending a PM to Sandy/Black Kitty will convince you otherwise about your impressions of insulin resistance. Sandy can tell you about this first hand.

We generally encourage getting a cat tested for both acro and IAA at about 6.0u. The cost is minimally more to include the IAA test and it can all be run at the same time.

Adding another insulin is probably adding Humulin R to what you're doing. I would not suggest forging ahead with this until Sandy or Libby are around to help you. R is a very potent, fast acting insulin. Misusing it or using it incorrectly can be disastrous.
 
i think it would be very important to test for the iaa when you test for the acro. the tests at MSU for iaa is $15 - well worth it if you're testing for acro.

the strategies for both are different and if the acro came back negative you would be left uncertain what's going on with pinky. the main cost in both was not the testing, it was the shipping and the blood draw - btw, use Fed Ex, not USPS. I called the MSU lab and the tech who answered said they'd had lots of trouble with the USPS getting samples there successfully.

acro kitties don't necessarily have all the symptoms. they can be female and petite. i would assume that all of them would have some symptoms. i have noticed that punkin's stridor (the breathing sound that acros make if they have excess tissue in their airways) has disappeared since the SRT. his feet are still enormous, other than that i really don't see any visual indicators that he has acro.
 
Hi Sienne,

Don't misunderstand me I am completely aware of how insulin resistance impacts cat. I am in complete awe of how much insulin Sandy gave Black Kitty and how well she handled it all.

I was only relating what was told to me about the drawbacks of test. I think once you are into the really high doses you must be looking at insulin resistance , test or no test. But as I said a high IAA number would go a long way of explaining these high doses.

And your point about diasterous effects of using another insulin is exactly what I fear too.

Edit Doesn't anybody have anything good to say about how I handled the vet visit before scaring me to death? Another Edit: I am sorry to put it this way but I put alot into writing about vet visit and am very , very worried about possibility of acro and using another insulin. Feel ultra sensitive about pointing out the 'flaws' of my comments without nothing positive said.

Elaine and Pinky
 
:YMHUG: of course you did good! sorry! way to go with taking all the info in. an informed consumer is a consumer with power!

i'm sure no one is trying to scare you to death, i'm certainly not! i'm just trying to say good for you for covering your bases and you'll feel better with answers. the other good reason for doing both the iaa/acro tests is that some cats have both. the diagnosis will tell you what path to take. nothing to be afraid of. punkin's now 5 months past diagnosis and he's still doing fine, in fact, snuggled into a little ball under the table in front of me looking very cozy. he's the same sweet kitty as ever! regardless of her diagnosis, pinky is the same sweet kitty as ever also! :-D
 
I can't comment on the info...
but I can certainly comment on how well prepared you were for the vet visit!

KUDOS TO YOU, ELAINE!

well done!

celi
 
I also think if you test for acro go ahead and do IAA as well just so you know. Do Lou actually had IMO all the classic signs of being acro he snores and has a heart issue is big pot belly not really a big chin or feet though honesty I was really shocked he was neg for it. At least with the testing it will give you a lot more knowledge for Pinky ((((hugs)))) from us
 
Hi there Elaine,

Just came by to throw in my $0.02 :-D

Your new vet sounds like she knows a little more that the average vet about FD and it sounds like you didn't get too much push back...nice.
Good call from the internal medicine specialist at the lab - acro is under diagnosed.

Now the part about IAA testing not being a particularly useful test for cats. . . I beg to differ ;-)
I'm sure that many cats on insulin do and would test positive for insulin auto antibodies. It's a question of how much.
I believe the normal range is up to 20% (anybody recall???) Black Kitty was 84% - that's considered extreme, and I can tell you it was.

Good for you for letting the vet know that you will probably do it anyway. Here is the link IAA test info
The peace of mind you will get - no matter the outcome - is well worth the $15.00. There are no drawbacks to having this test.
The Cushings test is not a big deal, it's a urine test and comes back pretty quick - I don't recall the sample having to go far away to a special lab.

I'm pleasantly shocked that the vet didn't try and get you to switch insulin! I had BKs (3rd) vet and his internist both pressuring me to switch to PZI. Had things not turned around they would have refused to renew BKs Lantus prescription.
I'm even more surprised that she talked about adding another insulin into the equation. It drove BKs vets absolutely crazy that I was using Humulin R (no prescription required) along with Lantus.
(I really pushed the vets way beyond their comfort zone).

Make the appointment for the tests, and in the meantime keep following the TR protocol. Hold each dose for 6 cycles, then evaluate and raise if needed according to nadirs, as indicated in the protocol.

Don't be afraid of the results and the changes they may bring. There is plenty of support for you here in LL, no matter the outcome.
Your not in uncharted territory :-D
 
I kid you not I must have read over 20 hours worth of material on the internet about acro and insulin resistance before that visit.

Julie's (and Punkins) help and support was invaluable as she gave me links that explained acro. From those I knew acro was under-diagnosed from the get go. But I was happy they came back supporting the test anyway.

I read all about treatment in Colorado (again thanks Julie) and lots of threads and research of how people dealt with both conditions.

I made the appointment not only because of the high dose but because Pinky actually has some acro symptoms--raspy breathing at times , gaining weight, possibly a big head. (not sure about this one) so I knew I wanted her tested and still do.

I will also do the IAA . I think they were just trying to say the test shows insulin resistance for alot of cats , high dose or not. Cats develop antibodies against the different species insulins that are used in diabetes treatment.

The vet spoke to an Internal Medicine specialist at IDEXX , a huge vet lab and information referral specialists. They actually would benefit if they pushed this testing but said it wasn't a good predictor of anything. Or something to that effect.

But I did tell my vet I wanted both tests done. I understand that it is felt that both tests are useful.

I think the greatest benefit to me for an IAA if it was abnormally elevated is that I would then ask for permission from Sandy to bring in a copy a Black Kitties Spreadsheet to show that huge doses of insulin MAY be required. But more importantly that the dosing moves rapidly. My new vet likes to hold the dose for much longer.

Sandy, I agree with you about the vet's suggestion of a second insulin as being valuable. Even though I really hope I don't have to do this as it is scary to me I knew you had to add this to your equation big time.

I also read about taking a cat to Colorado for acro treatment (which I would do in a second if it would help) but knowing that I can barely get poor howling Pinky to the vets I was upset to think what I may have to put her through and if she would even be able to stand the stress of it all. She is an extremely scared, non -easy going kitty. A total mama's girl though.

Elaine and Pinky
 
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