Welcome to FDMB.
Like the others noted, the issue of a "fruity" breath smell could be worrisome. Please let us know if you have urine ketone test strips and are able to get another test. Follow the directions on the package and let us know immediately if you get a result that's above "trace." Results that are more than trace need a vet visit as ketones can build up quickly and become an emergency. (When my cat was diagnosed, she was suffering from diabetic ketoacidosis and spent 3 days on the kitty ICU. Ketones can become life threatening.) The basic recipe for ketones is an infection + not eating + not enough insulin. If Nemo is eating, that's a good sign. One thing you can do that is good for Nemo regardless of whether there are ketones present is to add water to his food.
As for dose, with Lantus, doses are typically increased by no more than 0.5u. In fact, in most cases, the dose increase is in 0.25u increments. The rationale is that if you increase by too much, the resulting numbers may make it it difficult to discern whether high numbers are due to bouncing or insufficient insulin. You may want to take a look at the starred, sticky notes on the Lantus board. In particular, the Tight Regulation Protocol sticky will give you guidelines for how to approach dosing.
- Tight Regulation Protocol: This sticky contains the dosing protocol that we use here. There are also links to the more formal version -- the “Tilly” Protocol developed by the counterpart of this group in Germany, which was also published by Kirsten Roomp & Jacqui Rand, DVM in one of the top vet journals.
- New to the Group: Everything you wanted to know about this forum and more. Info on our slang, FAQs, links to sites on feline nutrition and to food charts containing carb counts, how to do a curve and the components to look for, important aspects of diabetes such as ketones, DKA, and neuropathy, and most important, info on hypoglycemia.
- Handling Lantus: how to get the maximum use from your insulin and what to not do with it!
- Lantus depot: This is an important concept for understanding how Lantus works.
- Lantus & Levemir: Shooting & Handling Low Numbers: What data you need in order to be able to work toward remission or tight regulation as well as information if you have a low pre-shot number or a drop into low numbers during the cycle.
With Lantus, each new dose needs time to prove its effectiveness. Thus, doses are adjusted every 3 days/6 cycles unless the numbers tell you that a dose reduction is warranted. So, Nemo has been at 1.0u for more time than is needed. However, your next dose was 2.0u, then you dropped back to 1.0 and then increased to 3.0u and back to 1.0u. Lantus likes consistency. Rapid dose changes usually result in wonky numbers. It also helps your decision making if you can get at least one test per cycle in addition to your pre-shot tests. The spot check is helpful since Lantus dosing is based on the nadir, not on your pre-shot test data.
I don't think the 1.0u was enough insulin but, you didn't know to get spot checks. Can you do your best to get some mid-cycle data so we can evaluate the dose? The high numbers you're seeing today are a result of Nemo dropping from the 400s to the 50s. This is what a "bounce" looks like. It can take up to 72 hours for the bounce to clear. The caveat here is what the results from a ketone test tell us. The presence of ketones trumps pretty much everything and we will help you to be aggressive regarding the dose providing that the ketones, if present, can be managed at home.