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CrispyCod

Member Since 2026
Hi everyone, just joined after reading through various threads to try and help our 12 year part Maine coon moggy, female, Sarafina. Recently suffered from pancreatitis which caused liver problems and jaundice. Diabetes was subsequently diagnosed (cause or symptom). Course of antibiotics complete and all clear, now learning to deal with the diabetes. I have charts, lots of data and details of current ‘protocols’ but thought I would introduce first. Current issue is BG values are not dropping, up to 10 units (6.7kg cat) of zinc based, just advised to switch to Lantus. 4 units (2 days) currently with no significant impact. As I said lots more details I can share if anyone is available to advise.

Thanks and look forward to discussing with what appears to be a very knowledgeable group!

In the UK by the way.

Chris
 
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Question.

So I have filled in the spreadsheet in the suggested format, where I am quite worried is that our vet continues to tell me to increase the dose, every 24hrs, which goes against everything I have read and when looking at her chart/curves the average BG seems to be increasing, with also increasing swings. Please could I get some advice on whether I should stick at the current 4 units of Glargine, continue to increase (not convinced at all on that) or drop it back and start again, I'm guessing patience is the key,though would be great to hear from someone, as we are getting increasingly stressed about our little lady. She seems okay, still active and running about, and loving a good fuss. No weight loss and regularly checking pee, with no concerns plus doesnt seem to be overeating like she was before, but still....any advice or guidance very welcome.
 
Welcome to FDMB.

You're correct. Based on the published research on using Lantus with cats, if you opt to follow the Tight Regulation Protocol (which is the published research), you need to let the Lantus dose stabilize. This typically takes 3 days/6 cycles. Your vet may be used to prescribing Caninsulin. (I'm guessing you're in the UK given it's a place where kitty = moggy.) It's also hard to know if the numbers are high because your cat needs more insulin or if it's an artifact of how quickly the dose has been raised and the size of the dose increase. We increase more slowly and in smaller amounts.

I'd encourage you to read over the sticky notes at the top if the Lantus board. There's information about how Lantus works in those notes. In particular, the dosing methods post may be helpful. That post also has links to the research articles.

Just so you're aware, there are some cats that require large doses of insulin. @Wendy&Neko has a great deal of experience with high dose conditions so hopefully, she'll stop by soon. I suspect that she'd like to see a more moderate approach to dosing so we can sort out what may be going on.
 
Was the zinc based insulin called Prozinc? If so, when someone switches from Prozinc to Lantus we typically switch to around the same dose, giving consideration to how low the first insulin dose is taking the cat.

More questions, sorry! Did you start out giving 4 units of Prozinc? That's a lot larger dose than we normally start with. And was Jan 29 her first day of insulin?

When you switched from Prozinc, did you also switch to U-100 syringes? Prozinc uses U-40 syringes but Lantus is a U-100 insulin. The reason I'm asking is that 4 units in a U-40 syringe would be 10 units of Lantus.

Your vet did have you increase by larger amounts than we would have and in some cases much faster. That means there are two possible scenarios. First is that you've overshot a good dose, but with all the data the Libre is giving you that seems unlikely as too high a dose will eventually cause numbers to dive. Second possibility is that she's a cat that needs larger doses of insulin. Once a cat gets to 6 units, we recommend getting a blood test for acromegaly (IGF-1 test). The Royal Vet Clinic will do the testing, and they are probably the best place in the world to deal with this condition.

One minor housekeeping thing, could you put a blank line after the last day of the previous insulin, and before starting Lantus, so it's more obvious to those of us looking at spreadsheets. You can label that line "start Lantus" or something like that.
 
Was the zinc based insulin called Prozinc? If so, when someone switches from Prozinc to Lantus we typically switch to around the same dose, giving consideration to how low the first insulin dose is taking the cat.

More questions, sorry! Did you start out giving 4 units of Prozinc? That's a lot larger dose than we normally start with. And was Jan 29 her first day of insulin?

When you switched from Prozinc, did you also switch to U-100 syringes? Prozinc uses U-40 syringes but Lantus is a U-100 insulin. The reason I'm asking is that 4 units in a U-40 syringe would be 10 units of Lantus.

Your vet did have you increase by larger amounts than we would have and in some cases much faster. That means there are two possible scenarios. First is that you've overshot a good dose, but with all the data the Libre is giving you that seems unlikely as too high a dose will eventually cause numbers to dive. Second possibility is that she's a cat that needs larger doses of insulin. Once a cat gets to 6 units, we recommend getting a blood test for acromegaly (IGF-1 test). The Royal Vet Clinic will do the testing, and they are probably the best place in the world to deal with this condition.

One minor housekeeping thing, could you put a blank line after the last day of the previous insulin, and before starting Lantus, so it's more obvious to those of us looking at spreadsheets. You can label that line "start Lantus" or something like that.
Hi Wendy, thanks for the message, no worries on the questions, more than happy to answer as I am sure it will help.

Sooo.
Yes, Prozinc is the name. I was told to minimize the dose back to 3 by the vet.
we started with a dose of 2 units of prozinc, I 'll have to check my data again as I realise the chart starts at 4. 29th was definitely the start date though or the night before when we got her home. She was in the vets for a couple of weeks whilst they dealt with the liver/jaundice etc
We switched to U100 syringes, via pen, needles are 31g 4mm, but was concerend it wouldnt go through the skin layer so using 31g 8mm.
4 prozinc = 10 lantus, I am surprised I thought it was the other way around, which suggests we have backed off her dose significantly?
I am aware of the possibility of Acromegaly, but no clinical symptoms and again the vet dismissed it when asked, possibily as they had tested for it, (possibly by scans looking for growths) which they said were all clear. but will have to double check. When I get a mo I will add both the original and the latest blood tests (everything standard was back to normal) and add them to her chart.
Chart updated for housekeeping

Looking at a timeline chart and some other data I put together (both attached) showing food, insulin timings and amount plus BG it looks like her levels are on average, getting higher, despite the increasing doses, which makes me think there is a bounce thing going on, especially as there is a sharp increase in BG straight after her dose, although that could be just the timing of the previous dose running out, I dont know!

Looking for some opinions (obviously will make the final decision ourselves) on what protocol we should follow going forward, not convinced continuing to just increase is right, but not sure!

Should we hold at 3 for a day or two more (6 cycles) should we go to equivalent, ie 10 units (although this would put her at the max of 1.5 units per kg) at a loss, really, just hoping we havent been patient enough and things will become clearer.

To add to the worries, the local vet (not the specialist) broke the first sensor, then fitted the second one right over her shoulder blade, so it wobbled itself off, so I cant get readings today until the new one is fitted tomorrow.

At a loss on where to go next, as I am sure everyone here can understand, very stressful and frustrating.

Any thoughts, would be very much appreciated.

Thanks again Wendy for responding and the information, its much appreciated.

Chris, Claire, Sarafina and Simba!
 

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4 prozinc = 10 lantus, I am surprised I thought it was the other way around,
4 units of Lantus in a U-40 syringe would be the equivalent of 10 units of Lantus in a U-100 syringe. That's why we want to make sure you've switched to the U-100 syringes and aren't still dosing with the U-40 ones. Not the first time that's happened! Typically if someone is dosing X units of Prozinc in a U-40 syringe, we suggest they switch to X units of Lantus using U-100. So yes, you are significantly underdosing now. Make sure you test frequently for ketones.

I am aware of the possibility of Acromegaly, but no clinical symptoms and again the vet dismissed it when asked, possibily as they had tested for it, (possibly by scans looking for growths) which they said were all clear. but will have to double check.
The majority of cats with acromegaly do NOT have clinical signs at diagnosis, perhaps only the dose size. After her diabetes diagnosis, Neko had no physical signs, not even with scans. It was the size of dose that triggered me to get the blood test done. Vets "of a certain age" were taught that acromegaly is rare. But research done at RVC showed that about one in four diabetic cats has it. I had to beg my vet to humour me and get the tests done. They are typically an extra test outside the normal blood panels.

which makes me think there is a bounce thing going on, especially as there is a sharp increase in BG straight after her dose,
With Lantus, because it is a depot style insulin, there can be a temporary couple cycle increase in numbers right after the dose increase. We aren't sure why this thing we call New Dose Wonkiness happens, but it might be something to do with the depot of the new dose rebuilding. This doesn't happen with Prozinc. There are other reasons for higher numbers too, some type of insulin resistance being one of them.

Looking for some opinions (obviously will make the final decision ourselves) on what protocol we should follow going forward, not convinced continuing to just increase is right
If you are feeding just low carb food (wet or raw), and can get enough tests, with the Libre gives you, you can follow Tight Regulation. That is the protocol I'd recommend for higher dose cats, as it allows you to reach a better dose faster. Lantus takes 5-7 days for the depot to build, but TR does allow you to increase faster in the beginning if you aren't seeing anything under 300.

Many people here attach their own Libres. More information here: Getting Started With Continuous Glucose Monitors (CGMs) for Diabetic Cats
 
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