my cat's glucose levels don't drop - I need some help

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Jhony

Member Since 2021
Probably this may not be the place to post this, but I’m new on this forum.

I already posted the following text on Feline Diabetes’ Facebook Group. I just need some advice from you.

My cat, Nino, was diagnotised in May and his treatment started with Caninsulin, but then it was switched to Lantus. No matter how much the insulin dose increases, his glucose levels always stay above 400. My vet wanted to give him 4 units, but I completely refused because I think my cat is overdosed and 4 units seemed totally crazy to me. In addition, he prescribed dry food for cats with gastritis (Royal Canin brand), which doesn’t have any sense because my cat doesn’t have gastritis problems.

On August 4 2021, I decided to completely remove the dry food and replace it with only low-carb wet food in hopes that his glucose level would drop to better levels. However, I keep seeing their levels stay the same. The most unfortunate thing for me is that I cannot measure his glucose during the day because my cat is not living with me. I live in England, and my cat is under the care of my mother and my sister in Portugal, and for work reasons they can only measure his glucose levels before injecting him insulin, with some exceptions on their days off.

I was on holiday a few days ago in Portugal and I was in charge of measuring my cat's glucose during the day and sometimes at night. I was very depressed not being able to do anything to lower his glucose levels and since then I have been having moments of anxiety, despite the fact that my cat has gained weight and behaves like a normal cat. Every day I expect better levels, and I feel too disappointed when I always see the same levels. I literally hate numbers over 400.

On the other hand, the day I arrived in Portugal on August 4, my sister didn’t follow my instructions and injected my cat with 2 units of lantus instead of 1 unit, which caused his levels drop to 88 at the time of inyecting him, but I didn't inject him. The next glucose level was kept at 122 without any insulin injection for 12 hours, but 24 hours later his glucose levels were over 400. The downside is that by not giving him insulin for 24 hours it caused his blood ketones to rise to 1.0 and then 1.4. I spent 4 days monitoring his ketones until the last measurement I took him was at 0.6. I was surprised that it took almost a full day to go from 88 to over 400.
Additionally, a couple of days ago we were giving him 1.75 units and his levels began to rise to more than 500, which made me suppose that he was counter-regulating and for that reason I lowered the dose to 1.5. units. The next glucose level before I could inject him was 143, which made me think that 1.75 was indeed a lot of insulin and 1.50 was still a lot of insulin. One hour later his glucose rose to more than 370. Probably was a mistake not continue giving him 1.50 units for at least one week, but I was worried because his glucose level dropped from 448 to 143, and I assumed it was probably lower during the day.

The few times that we have measured my cat's glucose during the day (+3, +6 or +8), his nadir behave very strangely. I have read that with Lantus the nadir can occur 6 hours later, but in my cat I have noticed that it can be at any time, even a few minutes after the injection or even after 08 hours because I don´t find sense that sometimes at +6 his glucose level has dropped to 300 and by the next measurement may be above 500 even if I gave him a low carb wet meal.

I'm not an expert on this feline diabetes, but you have no idea how much information I read on a daily basis trying to understand because I can't get my cat's glucose levels down. My cat is a healthy cat: no pancreatitis, no liver or kidney problems, much less thyroid. Only diabetes drives me crazy.

I hope you can give me some advice or "enlighten me" to know what else I can do.

I think you can see my Cat’s Spreadsheet in my signature. If not, you can see it here: https://docs.google.com/spreadsheets/d/10mKkIL--RoltEHU7UzwvbvZT4Raa3w43EQp0rszzHyU/edit

PD 1: Sorry for my English because it is not my first language.

PD 2: May cat is a big cat who eat between 400 grams and 500 grams of wet food, plus some sardines and chicken as a complement. His weight is about 7 kilograms, but not obese. Actually he lost 3 kg due to diabetes, and then gained 1 Kg. He is now getting 1.40 units of Lantus.
 
Welcome to FDMB.

I would strongly encourage you to read the "sticky" notes at the top of the Lantus forum. I suspect there are some basics about the way Lantus works that you and/or your family are not familiar with. Lantus is unlike most other insulin. It is a depot type of insulin and as such, if you make frequent changes in dose, you don't allow the insulin to work effectively. Dosing is not based on the pre-shot number, which is what it looks like you're doing. The dose is based on how low that dose brings down the numbers. Thus, it's also important to get at least one test during the cycle in addition to the pre-shot tests. Without any checks during the cycle and especially with very limited data from the PM cycle, you are missing a great deal of information. The lack of information makes decisions about dosing very difficult.

What we can't tell is how low the dose is taking your cat's numbers. The times when you're seeing lower numbers are triggering what we refer to as a "bounce." Your cat's body isn't used to those lower numbers. As a result, the liver and pancreas release a stored form of glucose along with counterregulatory hormones which cause the numbers to rise bask to those higher levels. In addition, although there isn't enough information to say this definitively, it doesn't look like your cat is getting enough insulin.

Regarding nadirs, they can and do shift. The difficulty is that you don't have enough data to get a good feel for when they typically fall. We recommend you do a curve -- testing every 2 hours for a 12-hour period -- in order to get a better sense of when Lantus onset and nadir fall. You may need to get a curve over several weeks in order to see a pattern.

I'm guessing this isn't want you want to hear given how little control you have over how your family is managing your cat's diabetes. Is there any way you can share some of the information from FDMB with them? (Or is there any way you can take your cat to England with you -- I know their regulations are challenging!)
 
I know you said they can't get a day reading because of work, but ask if they can get a before bed reading, and then lots of extra data on days off.
 
Thank you. I will try to encourage my family to check/test during the cycles in their days off, and do a curve once a week. I can’t take my cat to England for different reasons, but I would like to :(.

I have a doubt now. How to manage a situation where the levels are lower than 120? I have read I have to skip the dose until I see the level go up, but I have not seen this information in this group. This was one of the reason I skipped one dose some weeks ago, but the ketones made a party in my cat :blackeye:
 
I believe the information you're looking for is in the dosing methods sticky on the Lantus board. You want to scroll down to the section on Start Low Go Slow. There is information in that section on how to manage lower than expected pre-shot numbers.
 
Thanks, again. I lot of new information to manage. I feel bit confused. For now, I will hold the same doses for the numbers of days recommended on the Lantus forum, and follow the other recommendations.
 
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