Are you shooting .1u or 1 drop? I ask because from .25 one usually goes to .1u, and with Muffin, I've been at .1u and then also just a drop, so they are 2 different doses to us. For .1u, and it really varies depending on what syringe you are using, but I had just a sliver of daylight between the bottom of the 0 line and the top of the plunger. It just takes practice, drawing up that amt and squirting it onto waxed paper (using a colored liquid and an old syringe is helpful) to see if you are getting the amt you want, and then practice being consistent with it. For me, it was actually easier to draw both .1u and 1 drop than drawing .25u.