first off i want to say that we did use pzi for about 3 1/2 years so i am directly experienced with how it works.
now down to business

cats metabolize insulin twice as fast as humans do, thus the need for twice a day dosing. yes, rarely, and very rarely, there is a cat that only needs once a day dosing and often that is only when they are heading for remission or has another disease that throws their glucose levels out of whack occasionally.
if you are indeed dosing 10 units once a day per your vet's advice, that's just plain wrong unfortunately. 10 units on that syringe would be up to the number 10 on the syringe. starting doses are as was mentioned, usually around 1 to 2 units twice a day, which to be honest looks like nearly nothing in the syringe. 1/2 a unit either way makes a huge difference in our kitty's little bodies. sooo, can you clarify how far up on the syringe you are drawing? we just want to make sure kitty is not being accidentally overdosed as we are all animal lovers here and would never advise someone to do something that would hurt a kitty.
pzi starts working roughly 2 hours after the shot is given and continues to work usually til about 6-8 hours after the shot was given. then the body is on it's own. so once the insulin poops out after that 6-8 hours, the glucose levels rise and rise and rise for the next 16-18 hours, leaving kitty in numbers high enough to possibly bring on other diabetes related complications.
if shot twice a day, then you get longer coverage and shorter amounts of time in high glucose numbers.
mind you, some people see high numbers every day and think they must give more insulin. all that does is make the glucose drop and raise at a steeper angle, it doesn't buy more time of coverage for the day. that ends up with kitty on a roller coaster of high low high low high low and not only does it feel like crap to do that day in and day out, it eventually leads to a hypo and often a trip to the ER in hopes of saving kitty's life.
i've been here since 2006 and have lived with diabetes in my house every day since Mousie was diagnosed and in my own human family for many many years before that. i'm possibly looking at a diagnosis of it for myself very soon. i've learned more about this disease here on FDMB than anywhere else and if i am diagnosed with it soon, i can honestly say i don't mind it because of all i've learned in the last 4 years. . seriously
