Hi Sharon -
Sorry, I can't access FDMB on my phone, so just seeing this. Colin's SS looks like Graysons in early 2012. I barely got out of the pinks until we were getting closer to the dose, which for him was extreme - and not until about October 2012.
Looks like you're doing everything right, just have a kitty that isn't following the rule book - moreso than a normal diabetic. Your food is good, you're testing frequently... and he's still not responding much to higher doses of insulin. I would agree testing is in order.
Definitely have your vet contact MSU and request their mailer for the blood samples. It is much cheaper than FED EXing it yourself. I gave the info sheets to my vet, told them what I needed/wanted, and scheduled the blood draw AFTER the mailer arrived. At that time, some of the tests were ONLY done on Wednesday, so we drew on a Monday, shipped overnight Monday afternoon, and had results Thursday afternoon and Friday afternoon. (IGF-1 and IAA).
If the tests come back positive, and if you are considering treatments, here's some basic info.
I am in NC, about an hour from NC State vet school. After we got the test results, we went to NCSU for an ultrasound. This confirmed organmegaly (enlarged organs), though as they told me, not a slam-dunk diagnosis. But the elevated IGF, combined with correct diet, not responding to high doses of insulin, and enlarged (but not diseased) organs, was a good indication. We opted for treatment at Colorado State - at that time, it was pretty much the center of the universe in the states for SRT. It is now available many other places, though probably not the volume they've done at CSU. Some members of our Facebook Acro group have had the surgery - both at the Royal Veterinary College in London, and at Washington State University. Others have had cyber-knife SRT at Yonkers, NY. And some in Europe, where SRT and surgery are not an option, are using Pasireotide, which another member used successfully in a drug trial at RVC. All have achieved favorable results. Meanwhile, much of the early info I read about untreated Acromegaly life expectancy, has been disproven by other members - some have had as much as 3 yrs or more without treatment. Of course each one is different.
Please let me how I can help you, or provide additional info. I know this is a LOT to absorb. But, just like diabetes, there are many kitties living fruitful lives with the condition, no matter what path you might choose.
Lu-Ann