Can't seem to get my little man regulated :(

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My cat George has been diabetic for about 5 months now. Although he was very sick initially once we started getting him under control he seemed to be getting better....then he had two hypo seizures. We weren't checking his BG at home but as soon as he had the seizures we started. The vets we were seeing at the time had him on 5 units of PZI 2x a day which we think is what led to the seizures. We switched vets two days after the seizures and basically started over on his dosage.

The new vet is a cat-only clinic that has experience with diabetic cats so I like to think they know what they're doing, but my cat seems to be getting progressively worse. They immediately dropped his dosage to .5 units of PZI 2x a day and at first he seemed fine with that but then his BG began going up so we compensated and have kept compensating - we are now at 2.5 units 2x a day and his numbers are all over the place, recently getting into the 500s! He has dropped to 10.5 lbs (he was 16 before being diagnosed) and he seems hungry ALL the time. It's heartbreaking to hear him crying and feeling his bones but not wanting to feed him so I can keep him on his schedule.

He does have a UTI right now which we're treating with 2 Clavamox pills a day so I know that could also be playing havoc with his numbers but the hunger and weight loss are really starting to weigh on me. I would love for anyone to look at his chart and give me any opinions or advice they have. I know part of the problem with his numbers is that at one pre-shot he'll be super low so we don't give him insulin and then he's super high at the next pre-shot check - a few times we gave more insulin to try and compensate and maybe that was wrong bc that may have led to the low numbers the next time. I'm so confused about his dose right now because when he's high I feel like I need to give a little more but then when he's low and can't have insulin I feel like I'm just messing him up for later.

His diet right now is 2 1/2 cans of BFF wet food over 24 hours (I usually give 3/4 of a can before his shot and then another 1/2 between shots so he doesn't go 12 hours without eating). The BFF main ingredient is Tuna mixed with either chicken or other fish, I've tried giving him EVO, Friskie's, Fancy Feast and another brand I can't remember to try and give him some non-fish options but the BFF is the only wet food he'll eat. I've also tried sprinkling FortiFlora over some of the other brands and he'll sniff like he's interested but then won't eat the food.

Once he's finished with the antibiotics I plan on doing another curve - the last one was crazy, he was in every range but the 500s.

I'm just at a loss right now and don't know what to do :sad:
 
Hugs to you... I am really hoping others will come along who know about dosing, because my heart is breaking for you and George. This sounds so difficult. I thought I could at least bump the thread for you.

I don't know anything about PZI so I don't know how crucial the feeding/shot timing is, but I would be really tempted to feed him more if he is getting so thin and crying for food. Can you at least feed him more at his current mealtimes (although I know the scarf and barf can be an issue) so it will hold him over a bit longer? If he is losing weight and is skin and bones, I think he needs more food. Maybe you could also try some more FortiFlora or other probiotic on his regular food to try and help with the diarrhea?

I also think you are on the right track treating the UTI and fingers crossed this will make a difference in his numbers and overall health. I am really glad you are testing now because at least it gives you a handle on what is going on with the low AM preshots and high evening numbers. Just think if you didn't have that information and you were shooting the full dose every time.

My 2 cents. Again I am so sorry he is feeling so bad and that you are going through this stress.
 
I have been going through the same thing with my Annie. Recently she started peeing blood, so we took her in and hoped it was just a UTI. He did an ultrasound, and turns out her bladder, kidneys, and gall bladder have been SO inflamed and infected from what we just found out to be E-Coli. Maybe have your vet do an ultrasound so see how her bladder/kidneys are??
We are hoping after the antibiotics take the infection away, her numbers will come down.

From my experience so far, and it's only been 2 months since diagnosis, is that infection will cause wonky numbers, Annie has had a terrible infection that has probably been the cause of us being unable to regulate her.
 
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