? Cabergoline dose?

Kokkinoulis

Kokkinoulis

Member
Hi all,
@Wendy&Neko

My vet prescribed 1.3ml cabergolin every 24 hours with food. My cat is 6.7 to 6.6 kg. I saw that in most studies it is given every 48h. Is it common to be given every 24 h? I found only one study where cabergoline is given every 24 h
https://pubmed.ncbi.nlm.nih.gov/32684121/
What doses and when do you give to your cats? Please it is urgent because I have to give him the 1st dose today as I will be at home 3 days to closely monitoring him.
 
Kokkinoulis said:
Hi all,
@Wendy&Neko

My vet prescribed 1.3ml cabergolin every 24 hours with food. My cat is 6.7 to 6.6 kg. I saw that in most studies it is given every 48h. Is it common to be given every 24 h? I found only one study where cabergoline is given every 24 h
https://pubmed.ncbi.nlm.nih.gov/32684121/
What doses and when do you give to your cats? Please it is urgent because I have to give him the 1st dose today as I will be at home 3 days to closely monitoring him.
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Good morning,
My cat Eddie is nearly 11kg and has been on 1.1ML Cabergoline EOD for awhile and we have just changed the schedule to every 24hours, so I wouldn't worry.
Good luck with the Cabergoline.
When you have a moment would you ask your vet how the dose was calculated based on weight. I'd appreciate knowing that.
 
Some of our members have given it daily as I did while others have done it every 48 hours. Some started with every 48 hours and then switched to daily dosing.
 
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The starting dose is 10 mcg per kg of body weight. RVC found 10 mcg to be more effective. A South American study used 5 mcg per kg.

Some members cats have had GI side effects when beginning a daily dose of Cabergoline and reduced temporarily to every 48 hours and then increased it back to every 24 hours. Darcy only seemed to have diarrhea for a couple of days in the beginning as I recall.
 
Suzanne & Darcy said:
The starting dose is 10 mcg per kg of body weight. RVC found 10 mcg to be more effective. A South American study used 5 mcg per kg.

Some members cats have had GI side effects when beginning a daily dose of Cabergoline and reduced temporarily to every 48 hours and then increased it back to every 24 hours. Darcy only seemed to have diarrhea for a couple of days in the beginning as I recall.
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We're just going in the other direction, i.e. from EOD to once daily. Just don't know.
 
Suzanne & Darcy said:
What is the strength of your Cabergoline? Mine was 200 mcg/mL (so 200 micrograms per mL) and Darcy got .4 mL every day.
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The strength of my Cabergoline is 50μg/ml (Galastop syrup 50mcg/ml) Kokkinoulis weight is 6.7 kg so 1,3 ml. My concern is about frequency. I it has better results evry 24h or every 48h.
A study in the UK using a cabergoline dose of 10 μg/kg q24 reported no improvement in iGF1 concentrations (median starting iGF1 concentration >2000 ng/ml) or diabetic control in eight cats that completed the 90-day treatment period.*1
A second study, in Argentina, using a cabergoline dose of 10 μg/kg q48h, reported diabetic remission in 8/22 cats that completed 6 months of treatment; iGF1 normalised in 6/23 cats (median starting iGF1 concentration 1350 ng/ml), with those having smaller pituitary masses being more likely to achieve iGF1 control.*2 The greater likelihood of response to cabergoline in patients with smaller pituitary masses may be due to dopamine receptor 2 expression being decreased as pituitary mass size increases.

1. Scudder CJ, Hazuchova K, Gostelow R, et al. Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus. J Feline Med Surg 2021; 23: 131–137.

2. Miceli dd, García Jd, Pompili GA, et al. Cabergoline treatment in cats with diabetes mellitus and hypersomatotropism. J Feline Med Surg 2022; 24: 1238–1244
 
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Ignore the study in the UK - they tested too few cats. At the time they were doing their tests, a couple people here had debated joining the study but did not due to the amount of IGF-1 testing required. One of them, with kitty Marvin, went off of insulin while on cabergoline, while the study was being written up. And they knew about the result but it wasn't part of their study. The UK study started with cats doing 5 mcg per kg or 10, and found the one with 10 mcg did better. The South American study is much larger. In private correspondence with one of our members, they said they had tested 50 cats, with similar results as the paper.

Informal study here - I think most of the cats that went off insulin (actually most here period) were using 10 mcg per kg per day. For those lucky ones that went off of insulin, they typically reduced the dose afterwards.
 
Wendy&Neko said:
Ignore the study in the UK - they tested too few cats. At the time they were doing their tests, a couple people here had debated joining the study but did not due to the amount of IGF-1 testing required. One of them, with kitty Marvin, went off of insulin while on cabergoline, while the study was being written up. And they knew about the result but it wasn't part of their study. The UK study started with cats doing 5 mcg per kg or 10, and found the one with 10 mcg did better. The South American study is much larger. In private correspondence with one of our members, they said they had tested 50 cats, with similar results as the paper.

Informal study here - I think most of the cats that went off insulin (actually most here period) were using 10 mcg per kg per day. For those lucky ones that went off of insulin, they typically reduced the dose afterwards.
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Thanks Wendy. So his dose and frequency every 24 h is ok!! We started today before the evening shot. I mixed it with churu. I am closing monitoring now his BGs with libre and the lows I double check them with accu-check. It seems that liber is about 15 lower in the low numbers. I take also some cerenia in case of vomiting. Is it ok?

I added the below inormation in sticky
Acrocats, what were your IGF-1 results?

Diabetes diagnosis: 29Nov2023
Started caninsulin:11Dec2023
Started Lantus:20/Dec2023a
24Feb2024: 7.5 iu BID Lantus
29Feb2024:2.0 iu BID Lantus
Acromegaly diagnosis: 23Feb2024 IGF-1>1000 ng/ml Acromegaly: > 665 ng/ml Vet Med Labor GmbH Division of IDEXX Laboratories Leipzig
Started cabergoline: 01Mar2024 1.3 ml every 24h The strength of my Cabergoline is 50μg/ml (Galastop syrup 50mcg/ml) Kokkinoulis weight is 6.7 kg so the dose is 1,3 ml


At dose 7.5 iu after some days in greens suddently every changed and the dose has needed to be reduced so much.I suppose that could be IAA breakthrough or glucose toxicity breakthrough. This has happened before he started gabergoline.
 
Have your acro cats respiratory stridor, noisy breathing. My cat makes a strange noise especially during sleep and I am thinking if this is a stidor which is described in articles about feline acromegaly signs.
 
Wendy&Neko said:
Ignore the study in the UK - they tested too few cats. At the time they were doing their tests, a couple people here had debated joining the study but did not due to the amount of IGF-1 testing required. One of them, with kitty Marvin, went off of insulin while on cabergoline, while the study was being written up. And they knew about the result but it wasn't part of their study. The UK study started with cats doing 5 mcg per kg or 10, and found the one with 10 mcg did better. The South American study is much larger. In private correspondence with one of our members, they said they had tested 50 cats, with similar results as the paper.

Informal study here - I think most of the cats that went off insulin (actually most here period) were using 10 mcg per kg per day. For those lucky ones that went off of insulin, they typically reduced the dose afterwards.
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Hi again Wendy. I read an old post https://www.felinediabetes.com/FDMB...s-in-households-possibly-causing-acro.178383/
Interesting article about chemicals in households possibly causing acro
In 2013 I submitted my thesis for MSc in Enviroment and Health in Medical School of Athens with title:Endocrine disruptors as risk factors for developing diabetes.

Based mainly on epidemiological but also on in vitro and in vivo studies, the causal association of the increased presence of endocrine disruptors in the environment with the occurrence of metabolic disorders such as diabetes type 1 and 2, obesity and metabolic syndrome has been proposed in recent years. The endocrine disruptors that seem to be associated with diabetes include substances such as: persistent organic pollutants (polychlorinated biphenyls, dioxins and brominated flame retardants), pesticides, plastics and plasticizers (bisphenol A and phthalates) and metals (arsenic, cadmium and mercury). Endocrine disruptors that cause oxidative stress, overload or damage to β-cells of the pancreas, insulin resistance and/ or discontinuation of insulin secretion may contribute to the development of diabetes type 1 and 2. Furthermore, type 2 diabetes is directly related to obesity. Findings from epidemiological as well as from in vitro and in vivo studies respectively, suggest a link between exposure to EDCs and the development of obesity. In conclusion, animal studies and epidemiological studies suggest that endocrine disruptors are risk factors for developing diabetes type 1 and 2.
 
Kokkinoulis said:
Hi again Wendy. I read an old post https://www.felinediabetes.com/FDMB...s-in-households-possibly-causing-acro.178383/
Interesting article about chemicals in households possibly causing acro
In 2013 I submitted my thesis for MSc in Enviroment and Health in Medical School of Athens with title:Endocrine disruptors as risk factors for developing diabetes.

Based mainly on epidemiological but also on in vitro and in vivo studies, the causal association of the increased presence of endocrine disruptors in the environment with the occurrence of metabolic disorders such as diabetes type 1 and 2, obesity and metabolic syndrome has been proposed in recent years. The endocrine disruptors that seem to be associated with diabetes include substances such as: persistent organic pollutants (polychlorinated biphenyls, dioxins and brominated flame retardants), pesticides, plastics and plasticizers (bisphenol A and phthalates) and metals (arsenic, cadmium and mercury). Endocrine disruptors that cause oxidative stress, overload or damage to β-cells of the pancreas, insulin resistance and/ or discontinuation of insulin secretion may contribute to the development of diabetes type 1 and 2. Furthermore, type 2 diabetes is directly related to obesity. Findings from epidemiological as well as from in vitro and in vivo studies respectively, suggest a link between exposure to EDCs and the development of obesity. In conclusion, animal studies and epidemiological studies suggest that endocrine disruptors are risk factors for developing diabetes type 1 and 2.
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This is really interesting! As you may know I have been living with two kitties who are biological brothers. Blue was diagnosed with acro in 2017, had surgery in 2018 and only recently passed when he had cardiac arrest (a long story). His brother Eddie was diagnosed in 2020 and had surgery, etc. He is currently on Cabergoline.

Anyway, I've often, very often thought about mercury as being a key factor in acromegaly, the reason being none of the substances you mention are used in this household (pollutants, etc) but in their early days I thought I was being a good caregiver when I primarily fed them fish. Fish. Fish. Fish. Fish when they are, like the oceans, contaminated by mercury (from various sources). And of course, the pituitary is highly susceptible to mercury. I wish I knew then what I know now.
 
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