Budesonide question

[Manu & Porto]

For those using or having used budesonide, I was wondering what kind of compounded form are you using?
Ive been reading and asking around, and the pharmacy where they would prepare it, they would just use the normal form of budesonide, without the enteric coating that is being used in humans. It comes in powder, they mix it with cornstarch and put it in a capsule for administration. But right now, I am using the enteric coating ones, I dose them and would keep it up and administer it like this if I knew this is better than the non enteric coating.
So which form is better? The enteric coating or the normal form? Any ideas?

Thank you for input!

 

[Sandi and Toby]

We used a '1mg Budesonide mini melt' from Roadrunner pet pharmacy in AZ. It definitely does NOT have a coating, it is a tablet that dissolves very quickly once it hits saliva. If you haven't used Roadrunner, they are great. They get it to you very quickly - and I am clear across the country in NC.

Budesonide is listed on page 6 of https://www.roadrunnerpharmacy.com/img/RoadrunnerProductAndServicesGuide.pdf

Can't say which is better, but we had no trouble with administration of the mini melt.

[EDIT: OOoops, just noticed you are not in the U.S. so ignore the reference to Roadrunner, but the general information applies]

 

[Manu & Porto]

We used a '1mg Budesonide mini melt' from Roadrunner pet pharmacy in AZ. It definitely does NOT have a coating, it is a tablet that dissolves very quickly once it hits saliva. If you haven't used Roadrunner, they are great. They get it to you very quickly - and I am clear across the country in NC.

Budesonide is listed on page 6 of https://www.roadrunnerpharmacy.com/img/RoadrunnerProductAndServicesGuide.pdf

Can't say which is better, but we had no trouble with administration of the mini melt.

[EDIT: OOoops, just noticed you are not in the U.S. so ignore the reference to Roadrunner, but the general information applies]

Ok, then I will go ahead and order a compound from a pharmacy and see how it goes. Thank you so much Sandi, very helpful information!

 

[Larry and Kitties]

I have used the coated granules in the past. The standard human dose is 3 mg capsules. I divided one 3 mg capsule into three capsules.
"Enteric-coated formulations of budesonide resist gastric-acid degradation, delivering active drug to the small intestine and proximal colon [Fedorak and Bistritz, 2005]. Dissolution of the granules is delayed until the pH is greater than 5.5, normally occurring in the duodenum. A matrix of ethylcellulose with budesonide then controls the release of the drug into the intestinal lumen in a time-controlled manner."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513866/

 

[Manu & Porto]

I have used the coated granules in the past. The standard human dose is 3 mg capsules. I divided one 3 mg capsule into three capsules.
"Enteric-coated formulations of budesonide resist gastric-acid degradation, delivering active drug to the small intestine and proximal colon [Fedorak and Bistritz, 2005]. Dissolution of the granules is delayed until the pH is greater than 5.5, normally occurring in the duodenum. A matrix of ethylcellulose with budesonide then controls the release of the drug into the intestinal lumen in a time-controlled manner."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513866/

Thank you, Larry! Did you use the compounded one as well? Is there a notable difference?
My worry is, if it works, dont break it. These beads work for my boy, but everybody seems to be using the compounded version so I hope the compounded one will work as well...

 

[Larry and Kitties]

NO, I only used the granules. From what I have read onte EC budesonide should work better since about the full dose gets to the intestines where it is needed. For the non-EC budesonide some would get destroyed in the stomach and never make it to the intestines.