Yep. I have two boy cats and two other female cats. Since Lucky's been in a room by herself, he's now taken to pouncing on one of the other females. He actually bit Lucky causing major scabing once and the other time causing an infection and it was nasty. So I try to monitor them when they are together. It seems to go in spurts. I've talked to my vet about maybe putting him on some prozac or something. He got worse when one of his (I call litter mates but they weren't really. They were just together at the rescue since kittens and they didn't thrive without each other. So I adopted both) had a stroke and had to be helped over the rainbow bridge. She really doesn't want to put a cat on medication unless is really necessary. But with Lucky in a room all day I see it's not just her. He's just a very sensitive cat that gets stressed out easily. So I have to go back to her and see if she can prescribe something for him. I know a friend had a cat that was put on lorazepam which I have for my anxiety at times. But don't want to give him any unless I get the vet to say how much and if I can try it.
The routine is during the day when I'm away Lucky gets the office with the spare twin bed in it. The rest of the cats get the roam of the house. Then at night the other cats get locked out into the basement and she gets the roam of the house until the AM. Now when I'm home if she wants out she can be let out. But I pull the dry food up and make sure that she can't get into it. So she is never again around the dry food. When I go away over night, if that happens, she stays in the office until we get back.