Jen&Eddie
Member Since 2013
Yesterday's Condo
Yesterday: AMPS/365, +2/329, +5/183, +6.5/141, +7.5/126, +8/120, +9.5/94, +10/103, +11/107, PMPS/116, +2/220, +2/182, +3/147, +4/128, +5/86, +5.5/96, +6/101, +7/128
Today: AMPS/436, +2.5/249, +6/185
Hi LL,
Deanna, Elise, and Wendy, thanks for stopping by Eddie's condo last night. He dipped his toes in green last night, so that was two back to back cycles with dips into green which doesn't happen much lately. I suppose those two back to back cycles were just too much for Eddie's panicky little liver. He didn't stay in green last night and it looks like he probably started heading up quite quickly after PM +6.
This morning, Eddie was blasting being cheerful, so his nasty red AMPS was a bit of a shock. DH retested and the 436 was the lower of the two tests. I got some BTB time and when I checked at +2.5, Eddie had dropped almost 200 points to 249.
At lunch time he's still going down, but had slowed down a bit. It will be interesting to see where he's at when DH gets his in-the-door test. I tried to explain to Eddie that there is no prize in FD for the biggest dive, but he still felt he deserved a treat.
Looking over Eddie's SS, it does seem that dropping after pre-shot seems to be happening fairly frequently as of late. I'm toying with the idea of feeding at PS, +1, and +2, rather than at PS and +2. I'm trying to figure out logistically if that will work. For clarification, it's my understanding that Lantus generally starts to onset around +2 or +3. Is that right? So, the early cycle drops are either 1) early onset, 2) overlap from the previous dose, 3) and/or bounce clearing. So, for a 200 point drop to occur by +2.5, it's either a big "chunk" of the current dose being utilized to metabolize that much excess glucose, or it's "bounce clearing."
I'm trying to wrap my head around what physiologically is happening with bounce clearing. I've been trying to put down on virtual "paper" for a long time my thoughts on bouncing, so I hope you'll forgive the novel here and the layperson's interpretation.... My understanding is that insulin down-regulates it's own receptor cells. So, when those cells are "full" of insulin, the insulin basically turns those cells off, until the effect of the downregulation wears off. Then, when the downregulation has worn off, the receptor cells "open" again, allowing active insulin from the shed to metabolize more glucose. Good nadirs means that the cells are able to metabolize sufficient insulin and glucose to bring the circulating glucose levels into the "normal range." When the cells are "full," they stop metabolizing the active insulin and the circulating glucose. Add the release of a glucose "bomb" from a panicky liver, and you've got a sharp spike in glucose that the receptor cells can't metabolize even though there's active insulin present, because the receptor cells are "full," and have been "shut off" by the down-regulatory effect of either the insulin, or due to glucose toxicity. Throw in some other counter-regulatory hormones that arguably have the effect of down-regulating the receptor cells, and you get the high-flat bounce cycles that last for several days. Glucose toxicity causes the receptor cells to downregulate as well, meaning that there aren't as many available cells to metabolize the insulin and glucose. Based on my understanding, too much insulin can also cause downregulation resulting in high flat cycles.
So, if my understanding about the physiological mechanism of bouncing is correct, and feel free to point out if I'm wrong, what if anything can be done differently about bouncing (and diving)?
Prayers and vines to all kitties and beans in need today.
Yesterday: AMPS/365, +2/329, +5/183, +6.5/141, +7.5/126, +8/120, +9.5/94, +10/103, +11/107, PMPS/116, +2/220, +2/182, +3/147, +4/128, +5/86, +5.5/96, +6/101, +7/128
Today: AMPS/436, +2.5/249, +6/185
Hi LL,
Deanna, Elise, and Wendy, thanks for stopping by Eddie's condo last night. He dipped his toes in green last night, so that was two back to back cycles with dips into green which doesn't happen much lately. I suppose those two back to back cycles were just too much for Eddie's panicky little liver. He didn't stay in green last night and it looks like he probably started heading up quite quickly after PM +6.
This morning, Eddie was blasting being cheerful, so his nasty red AMPS was a bit of a shock. DH retested and the 436 was the lower of the two tests. I got some BTB time and when I checked at +2.5, Eddie had dropped almost 200 points to 249.
At lunch time he's still going down, but had slowed down a bit. It will be interesting to see where he's at when DH gets his in-the-door test. I tried to explain to Eddie that there is no prize in FD for the biggest dive, but he still felt he deserved a treat. Looking over Eddie's SS, it does seem that dropping after pre-shot seems to be happening fairly frequently as of late. I'm toying with the idea of feeding at PS, +1, and +2, rather than at PS and +2. I'm trying to figure out logistically if that will work. For clarification, it's my understanding that Lantus generally starts to onset around +2 or +3. Is that right? So, the early cycle drops are either 1) early onset, 2) overlap from the previous dose, 3) and/or bounce clearing. So, for a 200 point drop to occur by +2.5, it's either a big "chunk" of the current dose being utilized to metabolize that much excess glucose, or it's "bounce clearing."
I'm trying to wrap my head around what physiologically is happening with bounce clearing. I've been trying to put down on virtual "paper" for a long time my thoughts on bouncing, so I hope you'll forgive the novel here and the layperson's interpretation.... My understanding is that insulin down-regulates it's own receptor cells. So, when those cells are "full" of insulin, the insulin basically turns those cells off, until the effect of the downregulation wears off. Then, when the downregulation has worn off, the receptor cells "open" again, allowing active insulin from the shed to metabolize more glucose. Good nadirs means that the cells are able to metabolize sufficient insulin and glucose to bring the circulating glucose levels into the "normal range." When the cells are "full," they stop metabolizing the active insulin and the circulating glucose. Add the release of a glucose "bomb" from a panicky liver, and you've got a sharp spike in glucose that the receptor cells can't metabolize even though there's active insulin present, because the receptor cells are "full," and have been "shut off" by the down-regulatory effect of either the insulin, or due to glucose toxicity. Throw in some other counter-regulatory hormones that arguably have the effect of down-regulating the receptor cells, and you get the high-flat bounce cycles that last for several days. Glucose toxicity causes the receptor cells to downregulate as well, meaning that there aren't as many available cells to metabolize the insulin and glucose. Based on my understanding, too much insulin can also cause downregulation resulting in high flat cycles.
So, if my understanding about the physiological mechanism of bouncing is correct, and feel free to point out if I'm wrong, what if anything can be done differently about bouncing (and diving)?
Prayers and vines to all kitties and beans in need today.
