Orion's PMPS is 80. Do I shoot? I can get a +2 but cannot guarantee any other monitoring overnight. The same thing happened 3 nights ago when his PMPS was 75.
Without you being available to monitor I can't advise you to shoot. Chances are that he'll start to come back up again but , if your +2 is the same or lower than the PMPS number , you would need to monitor the cycle.
He's clearing a bounce/filling the depot from the previous skip and you can't monitor tonight, I would skip. And I would take the dose down to 1.75 units tomorrow. It's better to have a dose you can shoot two times each day.