Kathleen and Fred
Active Member
Take a look at how we did on .4 over the weekend. Small bounce, but pretty much on target. Think we can go lower?? 
3/24 FRED AM=199(.4), +3.5=272;+10=220;PM=252(.6)
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Jen&Eddie
Very Active Member
Re: 3/24 FRED AM=199(.4)
Looking pretty good! I wouldn't reduce yet. Fred's not going real low for his nadir. There's no "protocol" for when to reduce on ProZinc, but I think most of us are generally reducing if nadirs are at or below 50. I personally have reduced to try to get a handle on dose duration. Fred's pre-shots are looking generally better. I actually might go back up to 0.6 to see if he might dip into those green numbers more.
Looking pretty good! I wouldn't reduce yet. Fred's not going real low for his nadir. There's no "protocol" for when to reduce on ProZinc, but I think most of us are generally reducing if nadirs are at or below 50. I personally have reduced to try to get a handle on dose duration. Fred's pre-shots are looking generally better. I actually might go back up to 0.6 to see if he might dip into those green numbers more.
Kathleen and Fred
Active Member
Re: 3/24 FRED AM=199(.4)
Ok I 'll try that next. Thanks. But I gotta say that as much as I want them.....greens scare me a little!! nailbite_smile
Ok I 'll try that next. Thanks. But I gotta say that as much as I want them.....greens scare me a little!! nailbite_smile
Jen&Eddie
Very Active Member
Re: 3/24 FRED AM=199(.4), +10.5=189
I hear ya! :mrgreen: As long as you're not going below 50, greens are good healthy numbers. The idea is the longer and closer you can keep kitty in "normal" numbers, which is approximately 50-120, the more likely they will ultimately be able to go OTJ. :smile:
Kathleen and Fred said:
I hear ya! :mrgreen: As long as you're not going below 50, greens are good healthy numbers. The idea is the longer and closer you can keep kitty in "normal" numbers, which is approximately 50-120, the more likely they will ultimately be able to go OTJ. :smile:
Kathleen and Fred
Active Member
Re: 3/24 FRED AM=199(.4), +10.5=189
Here's what I don't understand...if they are between 50-120 because they are taking insulin, how will they be able to maintain those numbers after the doses stop? Do you gradually get lower and lower in doses until they are OTJ? And what happens if they dip up to blue numbers every so often after they are OTJ?
Here's what I don't understand...if they are between 50-120 because they are taking insulin, how will they be able to maintain those numbers after the doses stop? Do you gradually get lower and lower in doses until they are OTJ? And what happens if they dip up to blue numbers every so often after they are OTJ?
Jen&Eddie
Very Active Member
Re: 3/24 FRED AM=199(.4), +10.5=189
I don't think anyone is quite certain about the physiology of how a kitty goes OTJ, but the gist is that their pancreas is functioning better and can keep up with the glucose without it getting too high. This is in combination with the body's cells using the glucose more efficiently, so it takes less exogenous (external) insulin to get those cells to use the glucose. And then there are some that always need that external insulin. If you have some time, do a search for "glucose toxicity". There are several well-written posts from other members on how high blood glucose (glucose toxicity) causes damage, which in turn makes kitty less able to process the glucose. It's a vicious cycle. Basically, keeping the cat in "normal" or at least below renal threshold numbers is (hopefully) breaking that cycle and allowing all parts of the complex metabolic process to heal.
Some kitties seem to go OTJ rather abruptly, and some take their sweet time and very gradually go down and down in dose until they don't need insulin anymore. Take a look at the sticki'ed thread at the top of the PZI board re: remissions and look over some of the spreadsheets there to see what some of them looked like as they were going OTJ.
After going OTJ, some kitties do tend to run a bit higher than non-diabetic kitties. Dipping into the blue once in a while usually isn't cause for alarm, and a lot of kitties will be in the low 100's before meals. It if becomes more frequent, or goes into the yellows or higher, that's often a sign that they're coming out of remission for any variety of different reasons.
I don't think anyone is quite certain about the physiology of how a kitty goes OTJ, but the gist is that their pancreas is functioning better and can keep up with the glucose without it getting too high. This is in combination with the body's cells using the glucose more efficiently, so it takes less exogenous (external) insulin to get those cells to use the glucose. And then there are some that always need that external insulin. If you have some time, do a search for "glucose toxicity". There are several well-written posts from other members on how high blood glucose (glucose toxicity) causes damage, which in turn makes kitty less able to process the glucose. It's a vicious cycle. Basically, keeping the cat in "normal" or at least below renal threshold numbers is (hopefully) breaking that cycle and allowing all parts of the complex metabolic process to heal.
Some kitties seem to go OTJ rather abruptly, and some take their sweet time and very gradually go down and down in dose until they don't need insulin anymore. Take a look at the sticki'ed thread at the top of the PZI board re: remissions and look over some of the spreadsheets there to see what some of them looked like as they were going OTJ.
After going OTJ, some kitties do tend to run a bit higher than non-diabetic kitties. Dipping into the blue once in a while usually isn't cause for alarm, and a lot of kitties will be in the low 100's before meals. It if becomes more frequent, or goes into the yellows or higher, that's often a sign that they're coming out of remission for any variety of different reasons.
Kathleen and Fred
Active Member
Going back to .6 t hopefully drive BGs lower.
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