Just a thought so don't shoot the poster :roll: She wasn't doing that bad on .50 and then you went to .80 and skipped .60. She's dropping too hard and too fast and not getting the duration. Now, maybe .60 won't give any longer duration, who knows.... afterall she is a cat.....but you could try giving her .60 in the a.m. and see what she does and if needed, than you could end up giving her another .60 mid-cycle which may lead you into t.i.d. dosing. Not easy on the body to go down like that and shoot back up. When using the conversion chart and a U100 syringe it makes it very easy to do increases of just .20......sometimes, as little as it is, that is all that is needed.