but thank you.Henry should have cleared the bounce. What we are seeing is not enough insulin.
Good job increasing! Thank you for yesterday’s link.You don’t need to link the SS in the text box each day
but thank you.
You’re welcome but usually my thoughts on FD are based on knowledge and experience.Marje when you analyze my personal spreadsheet of Henry's injection you looked at the days of no insulin along with 2 units and 0.5 unit.
You mention the 2.0 units appeared to be possibly enough (I know this is a observation and nothing is written in stone) but the BOUNCE could not be held off.
Can you explain your thoughts and no I'm holding to your thoughts after all their just thoughts nothing more.
Thank You
You’re welcome but usually my thoughts on FD are based on knowledge and experience.True, I do throw some thoughts out there sometimes in a brainstorming way
Yes, I studied his SS for some time to envision the “invisible” numbers based on the ones that were there. He didn’t really go that low on 2u (71 on the AT). That tells me that his good dose is likely close to 2u...or was at that time. The longer a cat stays in high numbers, the more glucose toxicity builds and it takes a higher dose of insulin to get the numbers back down. That’s why I want to reassess him after six cycles and bump him up because it’s looking to me like he’s going to need it.
With the TR protocol, as we get to a good dose that allows the beta cells to heal, there is enough insulin, the liver gets used to the new normal numbers, and the bouncing eventually stops. It looked to me like the 2u could get him into greens but couldn’t hold him there.
make sense?
So the liver has to calm down and this will allow us to determine the ideal dose for Henry?
The toxicity has to be brought down ==> So therefore the units required will be high temporary and then will be decrease to run parallel with the reduction of the toxicity?
Yes and no. I’m sure that’s not helpful but sometimes the dose can be the right one but the liver takes a while to get used to the normal numbers. I’ve seen cats bounce for a couple years and then the liver “snaps”, the cat’s BG becomes solid green, and there’s a race down the dosing ladder to remission. It doesn’t always happen that dramatically but sometimes it does. We determine the ideal dose by finding the one that keeps his nadirs in normal numbers and hope the liver “settles down” and the rest of the curve flattens out. I wish I could show you a SS but many of the older ones are no longer available.So the liver has to calm down and this will allow us to determine the ideal dose for Henry?
If glucose toxicity builds up, the kitty becomes a bit insulin resistant so we increase the dose slowly and systematically until we break through the resistance.The toxicity has to be brought down ==> So therefore the units required will be high temporary and then will be decrease to run parallel with the reduction of the toxicity?
Without more data, it’s hard to know exactly at what dose Henry started improving but when he did, the dose started dropping him low and he bounced. It appears it continued and he was in a dive/bounce type of pattern. Bouncing is a way the liver and pancreas protect the body from hypoglycemia but, in some cases, the body can’t release the counter regulatory hormones and glucagon fast enough and the cat drops into very low numbers and possibly symptomatic hypoglycemia.When you look at the personal spreadsheet of henry's injection, Your experience told you at one point the high units brought the toxicity down but Henry continue to receive high dose after that event occurred and was being overdose from that point forward?