? 04/29 Eddie 374 +8 385 PMPS 331 +8 416

Does anyone have any thoughts on what's happening with Eddie? He had lower numbers April 20-22 and got a reduction.

Then, nothing but high numbers, perhaps even more than can be considered a bounce? I'm worried. I increased by .5u two days ago and it's like I'm giving him H2O, not insulin.

Eddie is 6 months out of SRT and that seems part of the equation. I want to emphasize I am not being impatient. I am concerned. I'd like to think the acromegaly cells are desperate and creating a last--or one of this last--hurrah by spitting out GH. I just don't know.
 
Jodey&Eddie&Blue said:
'd like to think the acromegaly cells are desperate and creating a last--or one of this last--hurrah by spitting out GH.
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Never seen it work that way post SRT. Dead pituitary cells stay dead. The rest (if all tumour reached by SRT) are neutered and not replicating, until they die. In other words, once the dose starts going down, it keeps going down, intermixed with times when the dose is relatively stable.

Right now you are seeing NDW - pull on those patience pants. The only other thing I wonder about is other conditions, like teeth. Wasn't he in need of a dental?
 
Wendy&Neko said:
Never seen it work that way post SRT. Dead pituitary cells stay dead. The rest (if all tumour reached by SRT) are neutered and not replicating, until they die. In other words, once the dose starts going down, it keeps going down, intermixed with times when the dose is relatively stable.

Right now you are seeing NDW - pull on those patience pants. The only other thing I wonder about is other conditions, like teeth. Wasn't he in need of a dental?
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Yes, you're right about the cells not able to replicate but the radiation oncologist and the folks at WSU said the "death" can be cyclical since not all perish at the same time/rate. In other words, it can still secrete GH.
Eddie cannot undergo anesthesia again, especially for a lengthy procedure. Each time is really a risk. I feel caught between a rock and a hard place about that.
 
Yes cyclical, those times of "relatively stable" can last months, before action starts again. The tumour cells are neutered, live out their life producing GH, however long that is, then die. Hence the variability in how long there are "working" cells producing GH.

Has the vet ever talked about pulse dosing of antibiotics for his mouth? With CKD cats, or cats with other conditions that mean no anesthesia, it's an option.
 
Wendy&Neko said:
Yes cyclical, those times of "relatively stable" can last months, before action starts again. The tumour cells are neutered, live out their life producing GH, however long that is, then die. Hence the variability in how long there are "working" cells producing GH.

Has the vet ever talked about pulse dosing of antibiotics for his mouth? With CKD cats, or cats with other conditions that mean no anesthesia, it's an option.
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Yes, that's how it was explained to me too, especially around the unpredictability of action in relation to "relatively stable". Not for the faint of heart. It just gets to me every now and again when I'm really tired. I've been on deck with the grad student conference and dinner over the last few days in addition to my regular wind-up-the-term work, so I'm pooched.

I will ask the vet about pulse dosing, for sure, thanks.
 
Wendy&Neko said:
Do you get a break over the summer as far as work goes?
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Normally I would have a break because of the way I've arranged my teaching schedule. Usually I teach in summer session (6 week term May-June) and then get a break until teaching again in January term (i.e. 2024) but I've just been appointed, let me say this in small letters, associate dean of research and graduate studies in my faculty. I'm in the learning curve phase right now (official start July 1) and once I am on the job, as it were, I'll have a pretty regular kind of schedule with the exception of supporting graduate students in the MA, MFA and PhD programs and faculty research as well. I see it as an opportunity to do something creative in research community building. Things will level out soon and then they don't get busy until mid-September to mid-October, then again in January for a month or so and again at the end of term (April-May). So, the busy times are cyclical...Just right now I'm in the thick of it. :cat:(Blue):)(me):cat:(Eddie). Oh, and there are two other cats who have no special needs and a dog, but so far so good...
 
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