Description of IGF-1 from the US National Library of Medicine NIH: Insulin-like growth factor 1 (IGF-1) a growth hormone
Copied and Reposted from the old FDMB board.
Acrocats, what were your IGF-1 results?
Jess & Earl
Date: May 6, 2008 09:07PM
I've searched the board and it seems like >100 is considered indicative of acromegaly (MSU's normal range is 12-92), but I'd like to know what our acrocats' numbers have been. 120? Or more like 350?
Edited to add: I did an IGF-1 test on SettleDown (nee Wilson) and the result was 44 (normal).
Edited 2 times. Last edit at 08/28/08 11:57PM by Jess & Earl.
****************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Carolynn and Fletcher
Date: May 7, 2008 08:43AM
Fletcher's was listed as >203 (done at MSU) so the exact measurement couldn't be determined on the scale at that time.
The interpretation stated: "The insulin autoantibody concentration is normal, but the insulin like growth factor concentration in this cat is extremely high and in a range consistent with the diagnosis of acromegaly."
Carolynn
************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Vanassa and China
Date: May 7, 2008 09:50AM
This is what the interpretation stated for China:
"The elevated concentration of insulin-like growth factor 1 (IGF1) on this report is determined from dilution of this sample. Does this cat show physical changes that are consistent with acromegaly? It is recognized that elevations of this hormone may occur as a metabolic response to diabetes mellitus in some cats, but I think this result higher than what would be expected in that latter scenario". "
China was listed as >275 and it was done at MSU as well.
*************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Patti and Merlin
Date: May 7, 2008 12:41PM
Merlin's IGF-1 was 183 (done @ MSU). I have to admit I never asked to see the actual report (but I think I'll get it now). By the time I had the bloodtest done - I more or less knew Merlin had acromegaly because of his crazy numbers, his large insulin requirements AND that his buddy Fletcher (whose numbers Merlin matched) already had a + acrotest!
*******************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Stephanie and Pheobe
Date: May 7, 2008 01:29PM
Oh Gosh......we have a different form of measurement over here - I know it was over 1,000 maybe over 1,200 - it was all over the phone with my vet and to be honest it was all a bit of a blurr....
I'll ask Beth though - I remember I sent her a text so she may remember - I'll ask what Pickle's was as well. (I also try and get a conversion)
********************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Dale Ann
Date: May 7, 2008 02:02PM
>147. Done at MSU, year - 2004.
Edited 1 times. Last edit at 05/09/08 09:16AM by Dale Ann.
********************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Beth & Pickles (Tam GA)
Date: May 7, 2008 03:13PM
Stephanie and Pheobe Wrote:
-------------------------------------------------------
> Oh Gosh......we have a different form of measurement over here
Not really surprising.
USA it's ng/ml and the rest of the world (SI units) it's nmol/L
ng/ml to nmol/L divide by 0.131
nmol/L to ng/ml multiply by 0.131
I know that Pheobe's IGF-1 was higher than Pickles and hers was 1948 nmol/L (255 ng/ml). Anything over 1000 nmol/L (131 ng/ml) is deemed indicative of aromegaly at Cambridge Labs who does the testing for the UK and some of Europe.
****************************************************************
Spunky is in the lead w/ 311... *NM*
Posted by: Jennifer and Spunky
Date: May 7, 2008 07:07PM
*************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Lara, Paddy (GA) & Maisie
Date: May 8, 2008 03:57PM
I was only told by my vet that Pad's had tested positive for Acromegaly, but when I got in touch with where the test had been carried out (Cambridge) they just said he was over 2000 (262), but didn't give me any more detail than that.
For some reason Steph, I'd got it into my head that Pheobe had a more accurate number given that was lower than 2000 - but I guess if it was higher than Pickles, that doesn't leave much of a gap!
I wonder if his levels would have been lower if I'd had the test done considerably earlier than I did - do they gradually increase over time or do they start and generally remain at the same level (assuming the hormone release doesn't have a break)?
Lara
**********************************************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Deanie and Boo
Date: May 8, 2008 04:38PM
How can 3 tests run at the same lab have values of >147, >203 and >275?
If Merlin's value was 185, why would any value be reported as >147? Their assay range evidently goes at least as high as 185 based on Merlin's result.
Something's not right there.
***********************************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Phoebe and Norton
Date: May 8, 2008 05:08PM
Could the test procedure / accuracy have been refined and improved over time?
When were these tests done? Month/Year would be enough
The testing accuracy / range would be dependent on the type and calibration of the equipment used - if that was changed or upgraded over time.
****************************************************************************************
Norton (GA) IGF-1 = 331 *NM*
Posted by: Phoebe and Norton
Date: May 27, 2008 12:26PM
**************************************************************************
Madison IGF-1 = 582
Posted by: Phoebe and Norton
Date: August 21, 2008 09:58AM
Joan and Madison currently post in the Lantus ISG.
Sandy and BlackKitty are having blood drawn for the acro test today (also Lantus ISG posters)
**********************************************************************************************
Henrietta's IGH1 = 331 *NM*
Posted by: C & Henrietta
Date: August 27, 2008 08:07PM
******************************************************************************************
Girlcat was 299 *NM*
Posted by: Girlcat & Hope
Date: September 7, 2008 11:40AM
*******************************************************************************************
wendy/milo IGF-1 = 345 *NM*
Posted by: jojo and bunny(GA) and Y
Date: November 29, 2008 01:26PM
***********************************************************************************
sandy/cecil IGF-1 = 641 *NM*
Posted by: jojo and bunny(GA) and Y
Date: November 29, 2008 01:27PM
************************************************************************************
Re: Acrocats, what were your IGF-1 results?
Posted by: Wendi and Milo
Date: January 1, 2009 11:43AM
Just curious . . .
Has anyone looked at what BG numbers the cat was having around the time of the test and/or how much insulin it was getting at the time?
Since there is such a wide spread between IGF-1 numbers, I'm just wondering if their BG's & insulin amounts may have something to do with it what IGF # they got at the time of the test.
Also, Milo has experienced at pretty much every dose along the way "better numbers" - then we have to raise the dose again, to see "better numbers, and so on. But, they have been (before the R) basically the same numbers no matter the dose.
So, is his IGF-1 # possibly lower at better numbers? And with each dose increase does the IGF increase - is that why a dose works for a few days, then has to be raised again - does the IGF output compensate according to the amount of insulin, eventually making another dose increase necessary?
Edited 1 times. Last edit at 01/01/09 11:58AM by Wendi and Milo.
*****************************************************************************************************************************
Insulin amounts & IGF-1 levels
Posted by: Carolynn and Fletcher
Date: January 2, 2009 07:51PM
Looking back at Fletcher's bg's and doses, he was getting about 20-25U per day at diagnosis, yet a month earlier he was needing 40+ units a day. I do believe that when Fletch isn't needing insulin, that his IGF-1 levels would probably be normal (or close to it). Since the IGF-1 levels can fluctuate on a daily basis, it would make sense that when the insulin needs are higher, the IGF-1 levels would be higher, too, although (of course!) there are no studies on this.
About the only way to know this would be to have our acrocats tested again to compare the levels of IGF-1 and insulin doses and see what the results are. That's definitely something I'd like to be able to do at some point.
***********************************************************************************************************************
Libby's Sterling = 281 *NM*
Posted by: Phoebe and Norton
Date: January 10, 2009 03:06PM
*****************************************************************************************************************
Leo - 481 *NM*
Posted by: Carolyn and Spot
Date: January 16, 2009 05:02PM
********************************************************************************************
Madison's follow up IGF-1 and cortisol levels
Posted by: Joan and Madison
Date: January 22, 2009 03:34PM
cross-posted from High Dose ISG:
Maddie's first IGF-1 test was on 8/6/08. The result was 582. At that time, she was getting 8.5u Lantus b.i.d. plus generous doses of R. She was routinely in the 300s and 400s with an occasional 500 or high 200 number thrown in for variety.
Her second IGF-1 test was done on 10/27/08 while she was at CSU for radiosurgery. The result was 569. Dr. Lunn also drew blood for adrenal function testing. At that time, Madison's Cortisol, Baseline was 293 and her Cortisol, 1 hr post ACTH was 432. During this time period, Madison was getting 20u Levemir (rarely any R), and was mainly in the 200s and 100s, with an occasional 300 or under-100 number.
On 11/15/08, she had her first post-surgery follow up test. Her IGF-1 was 537. Madison’s Cortisol, Baseline was 190 and her Cortisol, 1 hr post ACTH was 395. During this time period, her insulin needs were changing drastically. On the date of the test, she got 7u Lev + 2u R. Her numbers were sort of ugly, 400s and 500s, but once I got her back where she belonged (for that time), at 12u, her numbers got better. Shortly thereafter, she earned a rapid series of dose decreases again.
Her most recent post-surgery testing was on 12/15/08. I just got her test results back. Madison’s Cortisol, Baseline was 196 and her Cortisol, 1 hr post ACTH was 371. Her IGF-1 was up to 713! On 12/15/08, she was getting 6u Lev. Things were changing rapidly, so her numbers were up and down as I tried to find her new correct dose. Her numbers on 12/15/08, the date the blood was drawn for the IGF-1 test, her numbers were great, though.
It makes no sense to me that her IGF-1 could be up to 713, but her insulin needs decreasing. Any thoughts/comments?
=========
Sarah (Dusty) from the catacromegaly.com board wrote to me:
"I have no idea what is going on now with Maddie, but I found this article that says that IGF_1 has been tried as a treatment for diabetes: http://en.wikipedia.org/wiki/Insulin-like_growth_factor_1
IGF-1 has been manufactured recombinantly on a large scale using both yeast and E. coli. Several companies have evaluated IGF-1 in clinical trials for a variety of indications, including growth failure, type 1 diabetes, type 2 diabetes, amyotrophic lateral sclerosis (ALS aka "Lou Gehrig's Disease"), severe burn injury and myotonic muscular dystrophy (MMD). Results of clinical trials evaluating the efficacy of IGF-1 in type 1 diabetes and type 2 diabetes showed great promise in reducing hemoglobin A1C levels, as well as daily insulin consumption. However, the sponsor, Genentech, discontinued the program due to an exacerbation of diabetic retinopathy in patients coupled with a shift in corporate focus towards oncology. Cephalon and Chiron conducted two pivotal clinical studies of IGF-1 for ALS, and although one study demonstrated efficacy, the second was equivocal, and the product has never been approved by the FDA."
In the wiki article, it notes that: "..levels do not fluctuate greatly throughout the day for an individual person..." I wonder if that has been determined to be true for felines. I've been thinking about some questions that I want to ask Dr. Lunn (she's doing the radiosurgery trial study at CSU that Madison participated in) next time I talk to her. Does anyone have any suggestions?
Edited 1 times. Last edit at 01/22/09 03:36PM by Joan and Madison.
************************************************************************
nina/KB IGF-1 = 317 *NM*
Posted by: jojo and bunny(GA) and Y
Date: February 3, 2009 10:43AM
****************************************************************************
christina/Stormy IGF-1=521
Posted by: chriscleo
Date: February 19, 2009 05:36PM
test results came back 2/17/09.
********************************************************************************
Notes from an Acroperson
Posted by: Megan and Black Bear
Date: February 24, 2009 04:05PM
I have been reading all of your posts about your acrokitties with great interest. I have had symptoms of acromegaly for six years. My MRI's were "ambiguous" until a year and a half ago, when I had my first seizure. Shortly after that, my IGF1's started rising above normal. It was only then (after years of desperately trying to get doctors to believe that something was happening) that I could persuade an endocrinologist to even order the confirmatory "gold-standard" test for acromegaly in humans, the OGGT or oral glucose tolerance test. These came back positive; I got diagnosed with acro last summer and had surgery last September.
I've been working on a post about what it feels like to have this disease, which I want to post on the High-Dose forum. I have so much admiration and sympathy for you and your kitties. As for this question, in humans the IGF1 represents an average over time, not a snapshot, and thus shouldn't reflect day to day changes. That said, I've had double tests drawn at the same time come back with readings 20 numbers apart.
None of my experience has suggested that fluctuations in BG immediately affect IGF1 readings, but I'm not *really* a cat
On the other hand, everything in my experience has taught me to trust my own perceptions and observations first, and the lab numbers second. I've earned my insights. You *know* your cats better than any lab test does.
****************************************************************************
Re: Notes from an Acroperson
Posted by: Vanassa and China
Date: February 24, 2009 04:13PM
Wow Megan! This is really interesting! I would love to hear more about how it feels to have Acro. Although my baby has gone on to a better place now, I am very curious as to how he may have felt during the process the entire process. Please feel free to PM me or post on the board, as I am sure that others are curious as well- especially in the hi-dose group because most of us battle with Acro on a daily basis.
*****************************************************************************************************
Re: Notes from an Acroperson
Posted by: Beth & Pickles (Tam GA)
Date: February 24, 2009 05:40PM
We have often wanted to talk to human acromegalics, to try to get an understanding what it might be like for our feline friends. Thank you for posting.
Megan and Black Bear Wrote:
-------------------------------------------------------
> None of my experience has suggested that
> fluctuations in BG immediately affect IGF1
> readings, but I'm not *really* a cat
BG fluctuations are a result of changes in the IGF-1 levels. BGs don't affect IGF-1 levels.
**************************************************************************************************************
Re: Acrocats, what were your IGF-1 results?
Posted by: mrmush
Date: March 7, 2009 04:20PM
Sam Wade, diagnosed MSU 11/08 IGF-1 = 433
**************************************************************************************************
bonnie/porscha IGF-1 = 357 *NM*
Posted by: jojo and bunny(GA) and Y
Date: March 13, 2009 06:47PM
************************************************************************************************
Buckwheat IGF-1 = 196 ... IAA = 0
Posted by: KT & Buckwheat
Date: April 15, 2009 04:28PM
He has a differential diagnosis.
KT & Buckwheat
*********************************************************************************************
Boo-ki = 407
Posted by: Joan and Madison
Date: April 25, 2009 01:23PM
*************************************************************************************************
Toby IGF-1 = 256; IAA = 2
Posted by: Jill & Alex
Date: April 27, 2009 11:28AM
*****************************************************************************************************************
Re: Acrocats, what were your IGF-1 results?
Posted by: asil & mouf
Date: May 14, 2009 12:26PM
mouf just got results back... IGF-1 was 112..
interpretation said: the IGF is only slightly elevated and not as high as we usually see in acromegaly..
****************************************************
Juanita's Chika IGF-1 = 492
Posted by: Jill & Alex
Date: July 16, 2009 12:44PM
Edited 1 times. Last edit at 07/16/09 12:44PM by Jill & Alex.
**********************************************************************************
Re: Acrocats, what were your IGF-1 results?
Posted by: Barbara and Misha
Date: July 31, 2009 07:00PM
For the record, Misha's was 381 in July 09. Done at MSU.
Barbara
Edited 1 times. Last edit at 07/31/09 07:01PM by Barbara and Misha.
******************************************************************************************************
Kathy & Kitty IGF = 92?
Posted by: Heather & Boo
Date: August 1, 2009 09:04AM
Can't find the exact number, but it was the high end of normal. Depending on how he does, Kitty might get tested again later on.
**********************************************************************************************************
Copied and Reposted from the old FDMB board.
Acrocats, what were your IGF-1 results?
Jess & Earl
Date: May 6, 2008 09:07PM
I've searched the board and it seems like >100 is considered indicative of acromegaly (MSU's normal range is 12-92), but I'd like to know what our acrocats' numbers have been. 120? Or more like 350?
Edited to add: I did an IGF-1 test on SettleDown (nee Wilson) and the result was 44 (normal).
Edited 2 times. Last edit at 08/28/08 11:57PM by Jess & Earl.
****************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Carolynn and Fletcher
Date: May 7, 2008 08:43AM
Fletcher's was listed as >203 (done at MSU) so the exact measurement couldn't be determined on the scale at that time.
The interpretation stated: "The insulin autoantibody concentration is normal, but the insulin like growth factor concentration in this cat is extremely high and in a range consistent with the diagnosis of acromegaly."
Carolynn
************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Vanassa and China
Date: May 7, 2008 09:50AM
This is what the interpretation stated for China:
"The elevated concentration of insulin-like growth factor 1 (IGF1) on this report is determined from dilution of this sample. Does this cat show physical changes that are consistent with acromegaly? It is recognized that elevations of this hormone may occur as a metabolic response to diabetes mellitus in some cats, but I think this result higher than what would be expected in that latter scenario". "
China was listed as >275 and it was done at MSU as well.
*************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Patti and Merlin
Date: May 7, 2008 12:41PM
Merlin's IGF-1 was 183 (done @ MSU). I have to admit I never asked to see the actual report (but I think I'll get it now). By the time I had the bloodtest done - I more or less knew Merlin had acromegaly because of his crazy numbers, his large insulin requirements AND that his buddy Fletcher (whose numbers Merlin matched) already had a + acrotest!
*******************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Stephanie and Pheobe
Date: May 7, 2008 01:29PM
Oh Gosh......we have a different form of measurement over here - I know it was over 1,000 maybe over 1,200 - it was all over the phone with my vet and to be honest it was all a bit of a blurr....
I'll ask Beth though - I remember I sent her a text so she may remember - I'll ask what Pickle's was as well. (I also try and get a conversion)
********************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Dale Ann
Date: May 7, 2008 02:02PM
>147. Done at MSU, year - 2004.
Edited 1 times. Last edit at 05/09/08 09:16AM by Dale Ann.
********************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Beth & Pickles (Tam GA)
Date: May 7, 2008 03:13PM
Stephanie and Pheobe Wrote:
-------------------------------------------------------
> Oh Gosh......we have a different form of measurement over here
Not really surprising.
USA it's ng/ml and the rest of the world (SI units) it's nmol/L
ng/ml to nmol/L divide by 0.131
nmol/L to ng/ml multiply by 0.131
I know that Pheobe's IGF-1 was higher than Pickles and hers was 1948 nmol/L (255 ng/ml). Anything over 1000 nmol/L (131 ng/ml) is deemed indicative of aromegaly at Cambridge Labs who does the testing for the UK and some of Europe.
****************************************************************
Spunky is in the lead w/ 311... *NM*
Posted by: Jennifer and Spunky
Date: May 7, 2008 07:07PM
*************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Lara, Paddy (GA) & Maisie
Date: May 8, 2008 03:57PM
I was only told by my vet that Pad's had tested positive for Acromegaly, but when I got in touch with where the test had been carried out (Cambridge) they just said he was over 2000 (262), but didn't give me any more detail than that.
For some reason Steph, I'd got it into my head that Pheobe had a more accurate number given that was lower than 2000 - but I guess if it was higher than Pickles, that doesn't leave much of a gap!
I wonder if his levels would have been lower if I'd had the test done considerably earlier than I did - do they gradually increase over time or do they start and generally remain at the same level (assuming the hormone release doesn't have a break)?
Lara
**********************************************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Deanie and Boo
Date: May 8, 2008 04:38PM
How can 3 tests run at the same lab have values of >147, >203 and >275?
If Merlin's value was 185, why would any value be reported as >147? Their assay range evidently goes at least as high as 185 based on Merlin's result.
Something's not right there.
***********************************************************************************************
Re: Acrocats, what were your IFG-1 results?
Posted by: Phoebe and Norton
Date: May 8, 2008 05:08PM
Could the test procedure / accuracy have been refined and improved over time?
When were these tests done? Month/Year would be enough
The testing accuracy / range would be dependent on the type and calibration of the equipment used - if that was changed or upgraded over time.
****************************************************************************************
Norton (GA) IGF-1 = 331 *NM*
Posted by: Phoebe and Norton
Date: May 27, 2008 12:26PM
**************************************************************************
Madison IGF-1 = 582
Posted by: Phoebe and Norton
Date: August 21, 2008 09:58AM
Joan and Madison currently post in the Lantus ISG.
Sandy and BlackKitty are having blood drawn for the acro test today (also Lantus ISG posters)
**********************************************************************************************
Henrietta's IGH1 = 331 *NM*
Posted by: C & Henrietta
Date: August 27, 2008 08:07PM
******************************************************************************************
Girlcat was 299 *NM*
Posted by: Girlcat & Hope
Date: September 7, 2008 11:40AM
*******************************************************************************************
wendy/milo IGF-1 = 345 *NM*
Posted by: jojo and bunny(GA) and Y
Date: November 29, 2008 01:26PM
***********************************************************************************
sandy/cecil IGF-1 = 641 *NM*
Posted by: jojo and bunny(GA) and Y
Date: November 29, 2008 01:27PM
************************************************************************************
Re: Acrocats, what were your IGF-1 results?
Posted by: Wendi and Milo
Date: January 1, 2009 11:43AM
Just curious . . .
Has anyone looked at what BG numbers the cat was having around the time of the test and/or how much insulin it was getting at the time?
Since there is such a wide spread between IGF-1 numbers, I'm just wondering if their BG's & insulin amounts may have something to do with it what IGF # they got at the time of the test.
Also, Milo has experienced at pretty much every dose along the way "better numbers" - then we have to raise the dose again, to see "better numbers, and so on. But, they have been (before the R) basically the same numbers no matter the dose.
So, is his IGF-1 # possibly lower at better numbers? And with each dose increase does the IGF increase - is that why a dose works for a few days, then has to be raised again - does the IGF output compensate according to the amount of insulin, eventually making another dose increase necessary?
Edited 1 times. Last edit at 01/01/09 11:58AM by Wendi and Milo.
*****************************************************************************************************************************
Insulin amounts & IGF-1 levels
Posted by: Carolynn and Fletcher
Date: January 2, 2009 07:51PM
Looking back at Fletcher's bg's and doses, he was getting about 20-25U per day at diagnosis, yet a month earlier he was needing 40+ units a day. I do believe that when Fletch isn't needing insulin, that his IGF-1 levels would probably be normal (or close to it). Since the IGF-1 levels can fluctuate on a daily basis, it would make sense that when the insulin needs are higher, the IGF-1 levels would be higher, too, although (of course!) there are no studies on this.
About the only way to know this would be to have our acrocats tested again to compare the levels of IGF-1 and insulin doses and see what the results are. That's definitely something I'd like to be able to do at some point.
***********************************************************************************************************************
Libby's Sterling = 281 *NM*
Posted by: Phoebe and Norton
Date: January 10, 2009 03:06PM
*****************************************************************************************************************
Leo - 481 *NM*
Posted by: Carolyn and Spot
Date: January 16, 2009 05:02PM
********************************************************************************************
Madison's follow up IGF-1 and cortisol levels
Posted by: Joan and Madison
Date: January 22, 2009 03:34PM
cross-posted from High Dose ISG:
Maddie's first IGF-1 test was on 8/6/08. The result was 582. At that time, she was getting 8.5u Lantus b.i.d. plus generous doses of R. She was routinely in the 300s and 400s with an occasional 500 or high 200 number thrown in for variety.
Her second IGF-1 test was done on 10/27/08 while she was at CSU for radiosurgery. The result was 569. Dr. Lunn also drew blood for adrenal function testing. At that time, Madison's Cortisol, Baseline was 293 and her Cortisol, 1 hr post ACTH was 432. During this time period, Madison was getting 20u Levemir (rarely any R), and was mainly in the 200s and 100s, with an occasional 300 or under-100 number.
On 11/15/08, she had her first post-surgery follow up test. Her IGF-1 was 537. Madison’s Cortisol, Baseline was 190 and her Cortisol, 1 hr post ACTH was 395. During this time period, her insulin needs were changing drastically. On the date of the test, she got 7u Lev + 2u R. Her numbers were sort of ugly, 400s and 500s, but once I got her back where she belonged (for that time), at 12u, her numbers got better. Shortly thereafter, she earned a rapid series of dose decreases again.
Her most recent post-surgery testing was on 12/15/08. I just got her test results back. Madison’s Cortisol, Baseline was 196 and her Cortisol, 1 hr post ACTH was 371. Her IGF-1 was up to 713! On 12/15/08, she was getting 6u Lev. Things were changing rapidly, so her numbers were up and down as I tried to find her new correct dose. Her numbers on 12/15/08, the date the blood was drawn for the IGF-1 test, her numbers were great, though.
It makes no sense to me that her IGF-1 could be up to 713, but her insulin needs decreasing. Any thoughts/comments?
=========
Sarah (Dusty) from the catacromegaly.com board wrote to me:
"I have no idea what is going on now with Maddie, but I found this article that says that IGF_1 has been tried as a treatment for diabetes: http://en.wikipedia.org/wiki/Insulin-like_growth_factor_1
IGF-1 has been manufactured recombinantly on a large scale using both yeast and E. coli. Several companies have evaluated IGF-1 in clinical trials for a variety of indications, including growth failure, type 1 diabetes, type 2 diabetes, amyotrophic lateral sclerosis (ALS aka "Lou Gehrig's Disease"), severe burn injury and myotonic muscular dystrophy (MMD). Results of clinical trials evaluating the efficacy of IGF-1 in type 1 diabetes and type 2 diabetes showed great promise in reducing hemoglobin A1C levels, as well as daily insulin consumption. However, the sponsor, Genentech, discontinued the program due to an exacerbation of diabetic retinopathy in patients coupled with a shift in corporate focus towards oncology. Cephalon and Chiron conducted two pivotal clinical studies of IGF-1 for ALS, and although one study demonstrated efficacy, the second was equivocal, and the product has never been approved by the FDA."
In the wiki article, it notes that: "..levels do not fluctuate greatly throughout the day for an individual person..." I wonder if that has been determined to be true for felines. I've been thinking about some questions that I want to ask Dr. Lunn (she's doing the radiosurgery trial study at CSU that Madison participated in) next time I talk to her. Does anyone have any suggestions?
Edited 1 times. Last edit at 01/22/09 03:36PM by Joan and Madison.
************************************************************************
nina/KB IGF-1 = 317 *NM*
Posted by: jojo and bunny(GA) and Y
Date: February 3, 2009 10:43AM
****************************************************************************
christina/Stormy IGF-1=521
Posted by: chriscleo
Date: February 19, 2009 05:36PM
test results came back 2/17/09.
********************************************************************************
Notes from an Acroperson
Posted by: Megan and Black Bear
Date: February 24, 2009 04:05PM
I have been reading all of your posts about your acrokitties with great interest. I have had symptoms of acromegaly for six years. My MRI's were "ambiguous" until a year and a half ago, when I had my first seizure. Shortly after that, my IGF1's started rising above normal. It was only then (after years of desperately trying to get doctors to believe that something was happening) that I could persuade an endocrinologist to even order the confirmatory "gold-standard" test for acromegaly in humans, the OGGT or oral glucose tolerance test. These came back positive; I got diagnosed with acro last summer and had surgery last September.
I've been working on a post about what it feels like to have this disease, which I want to post on the High-Dose forum. I have so much admiration and sympathy for you and your kitties. As for this question, in humans the IGF1 represents an average over time, not a snapshot, and thus shouldn't reflect day to day changes. That said, I've had double tests drawn at the same time come back with readings 20 numbers apart.
None of my experience has suggested that fluctuations in BG immediately affect IGF1 readings, but I'm not *really* a cat
On the other hand, everything in my experience has taught me to trust my own perceptions and observations first, and the lab numbers second. I've earned my insights. You *know* your cats better than any lab test does.
****************************************************************************
Re: Notes from an Acroperson
Posted by: Vanassa and China
Date: February 24, 2009 04:13PM
Wow Megan! This is really interesting! I would love to hear more about how it feels to have Acro. Although my baby has gone on to a better place now, I am very curious as to how he may have felt during the process the entire process. Please feel free to PM me or post on the board, as I am sure that others are curious as well- especially in the hi-dose group because most of us battle with Acro on a daily basis.
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Re: Notes from an Acroperson
Posted by: Beth & Pickles (Tam GA)
Date: February 24, 2009 05:40PM
We have often wanted to talk to human acromegalics, to try to get an understanding what it might be like for our feline friends. Thank you for posting.
Megan and Black Bear Wrote:
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> None of my experience has suggested that
> fluctuations in BG immediately affect IGF1
> readings, but I'm not *really* a cat
BG fluctuations are a result of changes in the IGF-1 levels. BGs don't affect IGF-1 levels.
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Re: Acrocats, what were your IGF-1 results?
Posted by: mrmush
Date: March 7, 2009 04:20PM
Sam Wade, diagnosed MSU 11/08 IGF-1 = 433
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bonnie/porscha IGF-1 = 357 *NM*
Posted by: jojo and bunny(GA) and Y
Date: March 13, 2009 06:47PM
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Buckwheat IGF-1 = 196 ... IAA = 0
Posted by: KT & Buckwheat
Date: April 15, 2009 04:28PM
He has a differential diagnosis.
KT & Buckwheat
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Boo-ki = 407
Posted by: Joan and Madison
Date: April 25, 2009 01:23PM
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Toby IGF-1 = 256; IAA = 2
Posted by: Jill & Alex
Date: April 27, 2009 11:28AM
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Re: Acrocats, what were your IGF-1 results?
Posted by: asil & mouf
Date: May 14, 2009 12:26PM
mouf just got results back... IGF-1 was 112..
interpretation said: the IGF is only slightly elevated and not as high as we usually see in acromegaly..
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Juanita's Chika IGF-1 = 492
Posted by: Jill & Alex
Date: July 16, 2009 12:44PM
Edited 1 times. Last edit at 07/16/09 12:44PM by Jill & Alex.
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Re: Acrocats, what were your IGF-1 results?
Posted by: Barbara and Misha
Date: July 31, 2009 07:00PM
For the record, Misha's was 381 in July 09. Done at MSU.
Barbara
Edited 1 times. Last edit at 07/31/09 07:01PM by Barbara and Misha.
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Kathy & Kitty IGF = 92?
Posted by: Heather & Boo
Date: August 1, 2009 09:04AM
Can't find the exact number, but it was the high end of normal. Depending on how he does, Kitty might get tested again later on.
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