Good questions Lori!
To follow on the small increments question, I have wondered myself if ProZinc is more sensitive than PZI Vet, or if some kitties are more sensitive than others (on either insulin, or both). I have noticed with Bix (PZI Vet) that sometimes it seems like a 0.1, or even a fat/skinny (0.05) can make a big difference, but then other times it seems like small increments are useless for him. With him, it appears to depend on certain BG/dose combinations.
From a protocol perspective, what seems tricky to me is balancing the small increments factor with getting the cat successfully out of high #s. It seems like some cats, generally I would guess those who are responsive to a dose in the lower ranges, maybe under 2u or so, will do fine with a small increments SLGSBNTS (start low go slow but not too slow :lol: ) approach. But I worry about those who need higher doses, and potentially delaying regulation with a small increments approach. I have liked the perspective with PZI Vet of moving in 0.5 increments until you are closing in on better #s, then move to 0.2, but I'm not sure that applies for ProZinc, or that it can be clearly stated on any insulin. I think those of us who've been here a bit, when looking at a newbie cats #s have a feel for "this one needs to be more aggressive, this one needs to let things settle a bit and go slowly/small changes" but it's hard to quantify it in a way to explain easily to newbies.
So could be that 0.5 is actually a bad idea on ProZ, but on the other hand, it could be that it is still a good idea for some cats. When you look at cats for instance who only start doing well on a dose of something like 4u, it's hard to imagine that moving in 0.2u increments would be the right way to go. But then how to determine which cats are in which category, etc.? I think Lantus has some guidelines based on either weight or current dosage (haven't peeked over there in a while), that might be worth borrowing & seeing if that is a good fit for ProZinc?
Another question I would throw in for friendly discussion

is the how long to hold a dose question. Some have suggested ProZinc needs a little more time than PZI Vet to "settle in".
One thought I have to keep the contention levels low :mrgreen: is that we could start sort of a working doc that has ranges. Less of a firm protocol and more of a "here's what we've seen so far". So it could have ranges for certain things, rather than hard and fast guidelines. So it could read something like: "Based on the experiences of those using ProZinc, doses can be changed with every shot, however, some cats seem to do well if a steady dose is held for a few days". Of course at some point that approach may become vague enough to be mostly useless, but it might be a starting point to get some things down on paper without getting lost in trying to find a tight consensus.